[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100435868":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":10,"responsibleParty":31,"collaborators":10,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":10,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":42,"enrollmentInfo":43,"targetDuration":10,"studyType":46,"phases":10,"briefSummary":47,"conditions":48,"keywords":10,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":10},{"fullName":5,"class":6},"Children's Hospital of Fudan University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"VAP group",null,"Children with respiratory tract infection by mechanical ventilation",[13],"Diagnostic Test: mNGS diagnose of VAP",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","mNGS diagnose of VAP","This study is an observational study to evaluate the accuracy of pathogens in children with VAP tested by mNGS with no intervention. All patients from the cohort accept mNGS test and bacterial culture or virus PCR detection. A double sputum specimens are used for test.The reference standard is bacterial culture or virus PCR detection.",[9],[21],{"name":22,"affiliation":23,"role":24},"Guoping Lu, doctor","Children's Hospital of Fundan University","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Gangfeng Yan, doctor","CONTACT","8615900603082","jinyi036@126.com",{"type":32,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100435868","early-identification-of-pathogens-in-children-with-respiratory-tract-infection-by-mechanical-ventilation-using-mngs-100435868",false,"NCT04955821","Early Identification of Pathogens in Children With Respiratory Tract Infection by Mechanical Ventilation Using mNGS","Early Identification of Pathogens in Children With Respiratory Tract Infection by Mechanical Ventilation Using Metagenomics Next Generation Sequencing","Inclusion Criteria:\n\n* The time of invasive mechanical ventilation was less than 24 h when admitted to PICU Total duration of invasive mechanical ventilation is over 5 days\n\nExclusion Criteria:\n\n* Participants in other clinical trials in the same period No Informed Consent signed","ALL","29 Days","18 Years",{"count":44,"type":45},400,"ESTIMATED","OBSERVATIONAL","VAP（Ventilator-associated pneumonia）is the most common complication of mechanical ventilation in severely ill patients. VAP is defined as pneumonia occurring 48 hours after patients receive mechanical ventilation, including pneumonia occurring within 48 hours after extubation. It is one of the important causes of hospital-acquired infection, and the incidence of VAP in children on mechanical ventilation is about 10%, or 7\u002F1000 days of mechanical ventilation, and the overall mortality is 10-24%.Research has so far explained the relationship between bacteria isolated from human biological samples and VAP pathogens. Most studies are limited to the level of bacterial species, and there are few reports on bacterial genotyping, and there is a lack of scientific basis for the pathogenesis of VAP caused by bacteria in ventilator pipeline. The aim of the study is to investigate pathogen of the sputum in deep respiratory tract of patients with mechanical ventilation in PICU by the means of second generation sequencing (NGS).",[49],"VAP - Ventilator Associated Pneumonia","NOT_YET_RECRUITING","2026-02-12",{"date":53,"type":54},"2026-02-17","ACTUAL",{"date":56,"type":45},"2026-07-01",{"date":58,"type":45},"2026-12-01",{"name":5,"class":6}]