[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100468253":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":56,"collaborators":59,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":25,"eligibilityCriteria":68,"healthyVolunteers":65,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Alabama at Birmingham","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Breastfeeding Intervention Group","EXPERIMENTAL","Ten mother-infant dyads will be recruited to a six-month, community-based intervention aimed to promote sustained breastfeeding for at least six months among mothers of infants with sickle cell disease. The intervention will include an online, social media-based support group, online educational modules, monthly in-person educational sessions, access to free breast pump rentals, and monthly peer-led home visits by certified Vanderbilt-affiliated Maternal Infant Health Outreach Specialists. We obtain whole blood specimens for analysis of oxidative stress and inflammation at 3, 6, 12 and 24 months.",[13],"Behavioral: Breastfeeding support group",{"label":15,"type":6,"description":16,"interventionNames":17},"Observation Group","A 24 month observation of 10 mother-infant dyads affected by sickle cell disease that initiate breastfeeding. These dyads will observed for breastfeeding exclusivity\u002Fdosage and duration. We obtain whole blood specimens for analysis of oxidative stress and inflammation at 3, 6, 12 and 24 months.",[18],"Other: Observation",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Breastfeeding support group","community-based breastfeeding support group aimed to increase exclusive breastfeeding success rates among Black women",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Observation","Observe prospectively for breastfeeding initiation, duration and longitudinal health of child with sickle cell disease",[15],[31],{"name":32,"affiliation":5,"role":33},"Brandi M Pernell, DNP, MSPH","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","2058640238","brandimcclain@uabmc.edu",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-86.80249,33.52066,{"lat":51,"lon":50},[54],{"name":32,"role":36,"phone":55,"phoneExt":25,"email":38},"205-864-0238",{"type":33,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Brandi Pernell","Assistant Professor",[60],{"name":61,"class":62},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100468253","early-life-exposures-among-children-with-sickle-cell-disease-100468253",false,"NCT05377372","Early Life Exposures Among Children With Sickle Cell Disease","Inclusion Criteria:\n\n* mother of infant with sickle cell disease\n* resides within the city of Birmingham, Alabama or in close proximity\n\nExclusion Criteria:\n\n* prescribed teratogenic medications\n* no\u002Flimited internet access","FEMALE","18 Years","50 Years",{"count":73,"type":74},20,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study is being conducted to determine the relationship between early childhood exposures, such as Adverse Childhood Experiences, Social Determinants of Health and nutrition\u002Fbreastfeeding, among children with sickle cell disease, and behavioral interventions aimed to reshape psychological resilience and lifestyle factors towards positive health outcomes.",[80,81,82],"Sickle Cell Disease","Adverse Childhood Experiences","Breastfeeding",[84,81,82],"Sickle cell disease","2026-02-05",{"date":87,"type":88},"2026-02-09","ACTUAL",{"date":90,"type":88},"2026-02-01",{"date":92,"type":74},"2027-12-31",{"name":5,"class":6},1]