[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521101":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":19,"centralContacts":23,"locations":28,"responsibleParty":86,"collaborators":88,"id":99,"slug":100,"hasResults":101,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":101,"sex":106,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":7,"studyType":112,"phases":7,"briefSummary":113,"conditions":114,"keywords":7,"overallStatus":31,"whyStopped":7,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Children's Hospital of Eastern Ontario","OTHER",null,[9,13,16],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Magnetic Resonance Imaging (MRI)","Magnetic Resonance Imaging (MRI) is a non-invasive medical imaging technique that uses powerful magnets and radio waves to generate detailed images of the body's internal structures. The MRI intervention includes using a specialized MRI machine and lung imaging protocol.",{"type":10,"name":14,"description":15,"armGroupLabels":7,"otherNames":7},"Echocardiogram","An echocardiogram, often called an \"echo,\" is a non-invasive medical test that uses high-frequency sound waves (ultrasound) to create real-time images of the heart's structure and function. It provides valuable information about the heart's size, shape, and function.",{"type":10,"name":17,"description":18,"armGroupLabels":7,"otherNames":7},"Lung ultrasound","Lung ultrasound is a non-invasive imaging technique that employs high-frequency sound waves (ultrasound) to visualize the structures and conditions of the lungs. It is particularly valuable for diagnosing and monitoring lung-related conditions, such as pneumonia, pleural effusions, and pulmonary edema. The lung ultrasound intervention involves using an ultrasound machine equipped with a specialized probe gently placed on the chest to capture detailed images of the lungs and adjacent structures.",[20],{"name":21,"affiliation":5,"role":22},"Sherri Katz","PRINCIPAL_INVESTIGATOR",[24],{"name":21,"role":25,"phone":26,"phoneExt":7,"email":27},"CONTACT","(613) 737-7600","skatz@cheo.on.ca",[29,47,62,73],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"The Children's Hospital of Eastern Ontario","RECRUITING","Ottawa","Ontario","K1H 8L1","Canada","CA",{"type":38,"coordinates":39},"Point",[40,41],-75.69812,45.41117,{"lat":41,"lon":40},[44],{"name":45,"role":25,"phone":26,"phoneExt":46,"email":27},"Sherri Katz, Clinical Study Lead","2956",{"facility":48,"status":31,"city":49,"state":33,"zip":50,"country":35,"countryCode":36,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Mount Sinai Hospital","Toronto","M5G 1X5",{"type":38,"coordinates":52},[53,54],-79.39864,43.70643,{"lat":54,"lon":53},[57],{"name":58,"role":25,"phone":59,"phoneExt":60,"email":61},"Adel Mohamed, Site Lead","416-586-4800","7396","adel.mohamed@sinaihealth.ca",{"facility":63,"status":64,"city":65,"state":66,"zip":67,"country":35,"countryCode":36,"cosmosGeoPoint":68,"geoPoint":72,"contacts":7},"CHU-Sainte Justine","ACTIVE_NOT_RECRUITING","Montreal","Quebec","H3T 1C5",{"type":38,"coordinates":69},[70,71],-73.58781,45.50884,{"lat":71,"lon":70},{"facility":74,"status":31,"city":65,"state":66,"zip":75,"country":35,"countryCode":36,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},"Montreal Children's Hospital","H4A 3J1",{"type":38,"coordinates":77},[70,71],{"lat":71,"lon":70},[80,83],{"name":81,"role":25,"phone":7,"phoneExt":7,"email":82},"Gabriel Altit, Co-Site Lead","gabriel.altit@mcgill.ca",{"name":84,"role":25,"phone":7,"phoneExt":7,"email":85},"Larry Lands, Co-Site Lead","larry.lands@mcgill.ca",{"type":22,"investigatorFullName":21,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Division Head, Senior Scientist, Pediatric Respirologist",[89,91,93,95,97],{"name":90,"class":6},"The Hospital for Sick Children",{"name":92,"class":6},"MOUNT SINAI HOSPITAL",{"name":94,"class":6},"Hannover Medical School",{"name":96,"class":6},"St. Justine's Hospital",{"name":98,"class":6},"Montreal Children's Hospital of the MUHC","100521101","early-life-mri-biomarkers-of-longer-term-respiratory-morbidity-in-infants-born-extremely-preterm-emblem-100521101",false,"NCT06065215","Early-life MRI Biomarkers of Longer-term Respiratory Morbidity in Infants Born Extremely Preterm (EMBLEM)","EMBLEM","Inclusion Criteria:\n\n1. Infants born at \\\u003C29 weeks gestation;\n2. currently \\\u003C36 weeks PMA.\n\nExclusion Criteria:\n\n1. Known interstitial lung disease, congenital lung anomaly, ciliary dysfunction, immunodeficiency, cystic fibrosis, neuromuscular disease, or structural heart disease (other than atrial septal defect\u002Fhemodynamically insignificant ventricular septal defect\u002Fpatent ductus arteriosus);\n2. genetic syndrome or congenital anomaly;\n3. contraindications for MRI or transport;\n4. invasive or non-invasive ventilation that cannot be safely removed for MRI;\n5. current respiratory infection;\n6. family cannot speak English\u002FFrench;\n7. transferred to another hospital prior to baseline study visit\n8. not receiving follow-up at one of the study centres.","ALL","35 Weeks","21 Months",{"count":110,"type":111},319,"ESTIMATED","OBSERVATIONAL","Bronchopulmonary dysplasia (BPD) is a common, major complication of premature birth, associated with developmental and health consequences that continue into adulthood. Prediction of who will have these problems is challenging using traditional definitions of disease. It is believed that underdevelopment and injury occur in both lung tissue and the blood vessels in the lungs, with a sophisticated interplay between them that contributes to lung disease seen in prematurity. New magnetic resonance imaging (MRI) techniques can delineate tissue structure with unprecedented granularity, assessing lung tissue, blood vessels, and their interplay. The ability to identify, at an early stage, those infants destined for chronic lung disease with greater certainty will be useful in counseling families and critical for the effective introduction of promising new BPD therapies. 319 infants born less than 29 weeks gestation will be recruited from 4 centres, including 5 babies who received stem cell therapy in a clinical trial. Babies will be evaluated at 36 weeks post-conception with lung MRI, oscillometry (lung function), echocardiogram (heart ultrasound), and oscillometry. Lung health will be assessed every 3 months by phone questionnaire and chart review. At 18-21 months post-conception, babies will undergo neurodevelopmental assessment and lung function testing. The investigators will look at how well baseline MRI markers predict subsequent lung health and development, independently and combined with echocardiogram, lung ultrasound, and traditional markers of BPD. The investigators anticipate that these new MRI markers will measure lung health safely and longitudinally in babies born extremely preterm. By identifying predictors of longer-term lung disease, clinicians will be able to allocate resources to babies at the highest risk of severe disease. Further, The investigators envision that MRI will help identify babies who would benefit most from interventions like stem cell therapy and be useful for evaluation of future treatments.",[115,116],"Lung Function","BPD - Bronchopulmonary Dysplasia","2025-02-21",{"date":119,"type":120},"2025-02-24","ACTUAL",{"date":122,"type":120},"2024-03-30",{"date":124,"type":111},"2027-06-30",{"name":5,"class":6},4]