[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586774":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":30,"locations":35,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":10,"maxAge":10,"enrollmentInfo":62,"targetDuration":65,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Infants born preterm with history of IUGR",null,"preterm infants with history of intrauterine growth restriction",[13],"Diagnostic Test: fetal ultrasound to assess lungs, heart and diaphragm",{"label":15,"type":10,"description":16,"interventionNames":17},"Infants born preterm without history of IUGR","preterm infants without history of intrauterine growth restriction",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","fetal ultrasound to assess lungs, heart and diaphragm","The potential association between fetal ultrasound parameters (estimation of lung volumes, diaphragmatic thickness and contractility, cardiac thickness and kinetics), perinatal complications and respiratory function in the first years of life will be studied. Variables include: neonatal complications, non-invasive markers of respiratory status during neonatal admission (e.g. peripheral oxygen saturation\u002Frfaction of inspired oxygen ratio among others), lung function tests in the first two years of life.",[9,15],[25],"lung function tests",[27],{"name":28,"affiliation":5,"role":29},"Stefano Nobile, MD, PhD, MSc","PRINCIPAL_INVESTIGATOR",[31],{"name":28,"role":32,"phone":33,"phoneExt":10,"email":34},"CONTACT","+390630156937","stefano.nobile@policlinicogemelli.it",[36],{"facility":37,"status":38,"city":39,"state":10,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Fondazione Policlinico Gemelli IRCCS","RECRUITING","Roma","00168","Italy","IT",{"type":44,"coordinates":45},"Point",[46,47],11.10642,44.99364,{"lat":47,"lon":46},[50],{"name":28,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100586774","early-lung-function-trajectories-comparison-between-infants-with-and-without-intrauterine-growth-restriction-100586774",false,"NCT06919757","Early Lung Function Trajectories: Comparison Between Infants With and Without Intrauterine Growth Restriction.","Early Lung Function Trajectories: Comparison Between Infants With Intrauterine Growth Restriction and Appropriately Grown Ones.","ELFIGO","Inclusion Criteria:\n\n* Fetuses and Infants born before 32 weeks of gestation, with and without fetal growth restriction\n\nExclusion Criteria:\n\n* Lack of informed consent\n* Need for palliative care\n* Major malformations","ALL",{"count":63,"type":64},54,"ESTIMATED","2 Years","OBSERVATIONAL","During intrauterine life, some babies are smaller or grow less than expected. This fetal growth abnormality, called fetal growth restriction (FGR), can be diagnosed by ultrasound. Since there are currently no curative treatments for this condition, nor methods to optimize the growth of babies in the womb, the only effective strategy is intensive monitoring of fetal conditions, accompanied by early planning of delivery.\n\nThe diagnosis of early FGR (i.e. diagnosed before 32 weeks of gestation) confers a greater risk of short- and long-term respiratory problems.\n\nThe study aims to examine the association between parameters that can be assessed during pregnancy by ultrasound, such as the estimate of lung volumes, the thickness and contractility of the diaphragm, and cardiac kinetics, and any perinatal complications and respiratory function in the first years of life of premature infants, both with and without evidence of fetal growth pathology. Therefore, the study is divided into two phases: a prenatal and a postnatal phase.\n\nThe study includes two groups of patients:\n\n1. Study group: Fetuses and preterm infants with a prenatal history of FGR;\n2. Control group: Preterm infants without a prenatal history of FGR followed during neonatal follow-up.\n\nPregnant women with fetuses with FGR are followed at the Ultrasound clinics dedicated to Growth Pathology.\n\nThese pregnancies usually receive weekly ultrasound monitoring, which includes a Doppler study of the maternal and fetal circulation and an estimate of fetal weight every two weeks. Cardiotocographic monitoring is also planned once or twice a week, depending on fetal well-being.\n\nThe child will be assessed from a respiratory point of view during hospitalization and subsequently in the outpatient clinic, as required by clinical practice.\n\nHe\u002Fshe will undergo respiratory function tests. Visits are scheduled at 3, 6, 12 and 24 months of corrected age, during which at least two respiratory function tests will be performed.\n\nIn addition, routine clinical data (personal data, medical history, blood tests, biological and instrumental tests) present in the medical record of the child will be collected.\n\nData from preterm infants without fetal growth restriction will be collected after informed consent. These infants are routinely followed at our Institution and undergo clinical assessment and lung function tests in the first two years of life as previously indicated.",[69,70,71,72],"Intrauterine Growth Retardation (IUGR)","Lung Function Tests","Preterm Infant","Respiratory Monitoring",[74,75,76,77,78],"lung volume measurements","pulmonary function test","preterm birth","intrauterine growth retardation","oxygen saturation\u002Fphysiology","2025-08-25",{"date":81,"type":82},"2025-08-26","ACTUAL",{"date":84,"type":82},"2025-04-20",{"date":86,"type":64},"2027-03",{"name":5,"class":6},1]