[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619329":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":33,"locations":42,"responsibleParty":150,"collaborators":153,"id":165,"slug":166,"hasResults":167,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":167,"sex":173,"minAge":174,"maxAge":25,"enrollmentInfo":175,"targetDuration":25,"studyType":178,"phases":179,"briefSummary":181,"conditions":182,"keywords":185,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":199},{"fullName":5,"class":6},"Siriraj Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Norepinephrine 4 mg in 250 mL D5W, initiated at 0.05 mcg\u002Fkg\u002Fmin. Titrate by 0.025 mcg\u002Fkg\u002Fmin every 15 minutes if MAP \\\u003C65 mmHg, up to 0.15 mcg\u002Fkg\u002Fmin maximum. Rescue norepinephrine available if needed (separate line). Limb ischemia monitoring every 15 minutes.\n\nDuration: 24 hours.",[13],"Drug: Early norepinephrine administration and rapid dose adjustment",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","SHAM_COMPARATOR","Placebo (D5W 250 mL) with an identical dosing schedule. Rescue norepinephrine available via a separate line. Same monitoring protocols.",[19],"Drug: Control",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DRUG","Early norepinephrine administration and rapid dose adjustment",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":27,"otherNames":25},[15],[29],{"name":30,"affiliation":31,"role":32},"Chairat Permpikul, Professor","Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Titaporn Nasaarn, Medical Doctor","CONTACT","+66 82 429 5514","menatitaporn@gmail.com",{"name":30,"role":36,"phone":40,"phoneExt":25,"email":41},"+66 81 408 1676","chairat.per@mahidol.ac.th",[43,66,83,100,117,133],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Faculty of Medicine Siriraj Hospital, Mahidol University","RECRUITING","Bangkok Noi","Bangkok","10700","Thailand","TH",{"type":52,"coordinates":53},"Point",[54,55],100.47798,13.76266,{"lat":55,"lon":54},[58,62,64],{"name":59,"role":36,"phone":60,"phoneExt":25,"email":61},"Wasin Pansiritanachot, Medical Doctor","+66 89 680 8508","dr.wasinpan@gmail.com",{"name":59,"role":63,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"name":65,"role":32,"phone":25,"phoneExt":25,"email":25},"Surat Tongyoo, Associate professor",{"facility":67,"status":45,"city":68,"state":69,"zip":70,"country":49,"countryCode":50,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Kalasin Hospital","Kalasin","Changwat Kalasin","46000",{"type":52,"coordinates":72},[73,74],103.50658,16.43281,{"lat":74,"lon":73},[77,81],{"name":78,"role":36,"phone":79,"phoneExt":25,"email":80},"Suwimon Khansompop","+66942346394","yoyeeko@gmail.com",{"name":82,"role":32,"phone":25,"phoneExt":25,"email":25},"Suwimon Khansompop, Medical Doctor",{"facility":84,"status":45,"city":85,"state":86,"zip":87,"country":49,"countryCode":50,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Khon Kaen hospital","Khon Kaen","Changwat Khon Kaen","4000",{"type":52,"coordinates":89},[90,91],102.833,16.44671,{"lat":91,"lon":90},[94,98],{"name":95,"role":36,"phone":96,"phoneExt":25,"email":97},"Porntipa Tantibundit","+66815623688","tanti.porntipa@gmail.com",{"name":99,"role":32,"phone":25,"phoneExt":25,"email":25},"Porntipa Tantibundit, Medical Doctor",{"facility":101,"status":45,"city":102,"state":103,"zip":104,"country":49,"countryCode":50,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"Udon Thani Hospital","Udon Thani","Changwat Udon Thani","41000",{"type":52,"coordinates":106},[107,108],102.78589,17.41567,{"lat":108,"lon":107},[111,115],{"name":112,"role":36,"phone":113,"phoneExt":25,"email":114},"Anutr Thitayanapong","+66802598884","Anutr.thi@gmail.com",{"name":116,"role":32,"phone":25,"phoneExt":25,"email":25},"Anutr Thitayanapong, Medical Doctor",{"facility":118,"status":45,"city":119,"state":119,"zip":120,"country":49,"countryCode":50,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Hatyai Hospital","Hat Yai","90110",{"type":52,"coordinates":122},[123,124],100.47668,7.00836,{"lat":124,"lon":123},[127,131],{"name":128,"role":36,"phone":129,"phoneExt":25,"email":130},"Suratee Chobngam","+66074273100","areefsu123@gmail.com",{"name":132,"role":32,"phone":25,"phoneExt":25,"email":25},"Suratee Chobngam, Medical Doctor",{"facility":134,"status":45,"city":135,"state":136,"zip":137,"country":49,"countryCode":50,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"Maharaj Nakhon Si Thammarat Hospital","Nakhon Si Thammarat","์Nakhon Si Thammarat","8000",{"type":52,"coordinates":139},[140,141],99.96667,8.43333,{"lat":141,"lon":140},[144,148],{"name":145,"role":36,"phone":146,"phoneExt":25,"email":147},"Katsakorn Kheawkaew","+66886266464","katsakorn@gmail.com",{"name":149,"role":32,"phone":25,"phoneExt":25,"email":25},"Katsakorn Kheawkaew, Medical Doctor",{"type":32,"investigatorFullName":151,"investigatorTitle":152,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Wasin Pansiritanachot","Lecturer",[154,157,158,161,163],{"name":155,"class":156},"Maharaj Nakorn Si Thammarat","UNKNOWN",{"name":67,"class":6},{"name":159,"class":160},"Khon Kaen Hospital","OTHER_GOV",{"name":162,"class":156},"Udon Thani Regional Hospital",{"name":164,"class":156},"Hat Yai Hospital","100619329","early-norepinephrine-administration-and-rapid-dose-adjustment-100619329",false,"NCT07343206","Early Norepinephrine Administration and Rapid Dose Adjustment","Efficacy of Early Norepinephrine Administration and Rapid Dose Adjustment in Adult Septic Shock Patients: A Multicenter Randomized Controlled Trial","CENSER2","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Sepsis: SOFA ≥2 with suspected infection\n* Mean arterial pressure \\\u003C65 mmHg\n* Diagnosed within 3 hours\n\nExclusion Criteria:\n\n* Do-not-resuscitate orders\n* Pregnancy\n* Severe concurrent conditions (acute stroke, acute coronary syndrome, acute pulmonary edema, status asthmaticus, active gastrointestinal bleeding, status epilepticus, severe burn, severe trauma, and fatal drug overdose, End-stage malignancy\n* Peripheral arterial disease\n* Prior norepinephrine administration\n* Recurrent shock in the same patient","ALL","18 Years",{"count":176,"type":177},600,"ESTIMATED","INTERVENTIONAL",[180],"NA","The goal of this clinical trial is to determine whether early initiation of norepinephrine with rapid dose adjustment improves clinical outcomes in adult patients with septic shock. The study aims to evaluate the effect of early norepinephrine administration on mortality, hemodynamic stabilization, and resuscitation efficiency in adults aged 18 years and older diagnosed with septic shock.\n\nThe main questions it aims to answer are:\n\n* Does early norepinephrine administration with rapid dose titration reduce 28-day mortality compared with standard treatment?\n* Does early norepinephrine administration with rapid dose tiration lead to faster shock control and reduced fluid requirements without increasing treatment-related adverse events?\n\nResearchers will compare early norepinephrine administration with rapid dose adjustment to placebo with standard sequential resuscitation and rescue norepinephrine as needed to see if early vasopressor initiation improves survival, shock resolution, and safety outcomes.\n\nParticipants will:\n\n* Receive either norepinephrine or placebo infusion initiated within one hour of septic shock diagnosis, with dose adjustment every 15 minutes according to a standardized protocol\n* Undergo close hemodynamic and safety monitoring, including frequent vital sign assessment and limb perfusion evaluation\n* Receive standard sepsis care, including fluid resuscitation, antibiotics, and organ support as clinically indicated\n* Be followed for clinical outcomes and adverse events for up to 28 days after enrollment",[183,184],"Sepsis","Septic Shock",[186,187,188,189],"septic shock","norepinephrine","sepsis","hypotension","2026-04-21",{"date":192,"type":193},"2026-04-22","ACTUAL",{"date":195,"type":193},"2026-01-01",{"date":197,"type":177},"2028-03",{"name":5,"class":6},6]