[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631284":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":45,"collaborators":19,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":19,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":19,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":19,"overallStatus":28,"whyStopped":19,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"YKST02","EXPERIMENTAL","Participants receive YKST02 administered by intravenous infusion in this single-arm, open-label, dose-escalation study. Participants receive an initial dosing phase followed by subsequent administrations at escalating dose levels. Dose levels and dosing schedules may be adjusted based on safety, tolerability, and pharmacokinetic\u002Fpharmacodynamic (PK\u002FPD) data. A follow-up period is included for safety and efficacy assessments.",[13],"Drug: YKST02",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","YKST02 is an investigational drug administered by intravenous infusion. It is provided as a sterile formulation for clinical use. Dosing may vary based on study design and ongoing evaluation of safety, tolerability, and pharmacokinetic\u002Fpharmacodynamic (PK\u002FPD) data.",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Qiubai Li, MD, PhD","CONTACT","+86-27-85726338","qiubaili@hust.edu.cn",[27],{"facility":5,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Wuhan","Hubei","430022","China","CN",{"type":35,"coordinates":36},"Point",[37,38],114.26667,30.58333,{"lat":38,"lon":37},[41,43],{"name":22,"role":23,"phone":42,"phoneExt":19,"email":25},"+86-027-85726338",{"name":22,"role":44,"phone":19,"phoneExt":19,"email":19},"PRINCIPAL_INVESTIGATOR",{"type":44,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Qiubai Li","Professor and Chief Physician, Head of Rheumatology Department","100631284","early-phase-1-a-study-of-ykst02-in-participants-with-primary-iga-nephropathy-100631284",false,"NCT07498673","A Study of YKST02 in Participants With Primary IgA Nephropathy","A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of YKST02 in Participants With Primary IgA Nephropathy","Inclusion Criteria:\n\n* Diagnosis of primary IgA nephropathy (IgAN)\n* Proteinuria above a protocol-defined threshold at screening\n* Receiving stable standard-of-care therapy for IgAN for an adequate duration prior to enrollment, unless contraindicated or not tolerated\n* Women of childbearing potential must have a negative pregnancy test prior to study drug administration and agree to use effective contraception; male participants must agree to use effective contraception\n* Able to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Secondary IgA nephropathy (e.g., associated with liver disease, autoimmune disorders, infections, or other systemic conditions)\n* Other clinically significant renal diseases unrelated to IgAN (e.g., diabetic nephropathy, lupus nephritis, vasculitis)\n* Nephrotic syndrome considered unsuitable for study participation\n* Rapidly progressive glomerulonephritis or rapidly declining renal function\n* Estimated glomerular filtration rate (eGFR) \\\u003C45 mL\u002Fmin\u002F1.73 m²\n* Immunodeficiency or low immunoglobulin G (IgG) levels below normal\n* Clinically significant abnormal laboratory findings (e.g., hematologic, hepatic, or coagulation abnormalities)\n* Requirement for systemic corticosteroids for concomitant conditions\n* Use of immunosuppressive, targeted, or biologic therapies within a defined period prior to screening or anticipated use during the study\n* Prior treatment with B-cell-depleting or other targeted biologic therapies within a defined period\n* History of demyelinating disorders (e.g., multiple sclerosis)\n* Clinically significant cardiovascular or cerebrovascular disease within 6 months prior to screening\n* History of organ transplantation or planned transplantation during the study\n* Current dialysis or anticipated need for dialysis during the study\n* Major surgery within 4 weeks prior to screening or planned during the study\n* Active infection requiring systemic therapy, recent serious infection, or chronic\u002Frecurrent infections\n* Known active hepatitis B, hepatitis C, or human immunodeficiency virus (HIV) infection\n* Active or untreated latent tuberculosis\n* History of splenectomy\n* Uncontrolled comorbidities (e.g., poorly controlled hypertension or diabetes)\n* Malignancy within the past 5 years, except adequately treated non-invasive cancers\n* Known hypersensitivity to YKST02 or its components\n* Receipt of another investigational product within 4 weeks or 5 half-lives (whichever is longer) prior to screening\n* Receipt of live or attenuated vaccines within 4 weeks prior to screening or planned during the study\n* Any condition that, in the investigator's judgment, would make the participant unsuitable for the study","ALL","18 Years","75 Years",{"count":59,"type":60},12,"ESTIMATED","INTERVENTIONAL",[63],"EARLY_PHASE1","The goal of this clinical trial is to evaluate the safety and tolerability of YKST02 and to explore its potential to treat adults with primary IgA nephropathy (IgAN). The study will also assess how the drug moves through the body and how it affects the immune system.\n\nThe main questions it aims to answer are:\n\n* Is YKST02 safe and well tolerated?\n* Does YKST02 reduce protein levels in the urine?\n* How does YKST02 behave in the body (pharmacokinetics, PK)?\n* How does YKST02 affect the immune system (pharmacodynamics, PD)? Participants are adults with IgAN who have persistent proteinuria despite standard treatment.\n\nParticipants will:\n\n* Receive YKST02 by intravenous (IV) infusion\n* Be monitored after each dose for safety\n* Attend clinic visits for safety assessments and laboratory tests\n* Provide blood and urine samples during the study and follow-up period",[66],"Primary IgA Nephropathy","2026-05-07",{"date":69,"type":70},"2026-05-12","ACTUAL",{"date":72,"type":70},"2026-05-06",{"date":74,"type":60},"2027-06-30",{"name":5,"class":6},1]