[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544589":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":74,"collaborators":26,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":26,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":65,"whyStopped":26,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Verum (natural odour)","ACTIVE_COMPARATOR","Participants will inhale 50 uL of a natural odour contained in mini-inhaler over a period of 15 min.",[13],"Combination Product: Inhalation - Natural Odour",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Inhalation","PLACEBO_COMPARATOR","Participants will inhale 50 uL of placebo (propylene glycol) contained in mini-inhaler over a period of 15 min.",[19],"Combination Product: Inhalation - Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","Inhalation - Natural Odour","Inhalation of 50 uL of a natural odour via nasal septum mini-inhaler.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Inhalation - Placebo","Inhalation of 50 uL of Placebo via nasal septum mini-inhaler.",[15],[32],{"name":33,"affiliation":34,"role":35},"Katharina Timper, Prof. Dr. med.","University Hospital Basel, Department of Endocrinology, Diabetology and Metabolism","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","0041 61 328 57 42","katharina.timper@usb.ch",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Isabel M Hofer","0041 61 328 68 14","Isabelmarie.hofer@usb.ch",[46,63],{"facility":47,"status":48,"city":49,"state":26,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"University Hospital Basel","NOT_YET_RECRUITING","Basel","4031","Switzerland","CH",{"type":54,"coordinates":55},"Point",[56,57],7.57327,47.55839,{"lat":57,"lon":56},[60,61],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":42,"role":38,"phone":43,"phoneExt":26,"email":62},"isabelmarie.hofer@usb.ch",{"facility":64,"status":65,"city":49,"state":26,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":66,"geoPoint":68,"contacts":69},"University Hospital of Basel","RECRUITING",{"type":54,"coordinates":67},[56,57],{"lat":57,"lon":56},[70],{"name":71,"role":38,"phone":72,"phoneExt":26,"email":73},"Lolita Odermatt","+41 61 328 55 20","lolita.odermatt@usb.ch",{"type":75,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100544589","early-phase-1-abundance-of-a-natural-odour-in-human-cerebrospinal-fluid-after-olfactory-exposure---the-olfo-brain-study-100544589",false,"NCT06370845","ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study","Abundance of a Natural Odour in Human Cerebrospinal Fluid After Olfactory Exposure - the OLFO-Brain Study","OLFO-Brain","Inclusion Criteria Obese Participants:\n\n* Age 18-60 years\n* Written informed consent\n* Scheduled for routine liquor puncture\n* BMI ≥ 30 kg\u002Fm2\n* No proven diagnose of diabetes\n\nInclusion Criteria Lean Participants:\n\n* Age 18-60 years\n* Written informed consent\n* Scheduled for routine liquor puncture\n* BMI 18-25 kg\u002Fm2\n\nExclusion Criteria:\n\n* Known allergy to the natural odour\n* Acute upper respiratory tract infection, acute or chronic sinusitis\n* Present or past surgical intervention of the nasal cavity, the paranasal sinus, the pituitary or the frontal brain\n* Pregnancy\u002Flactation\n* Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease, severe renal impairment with an estimated glomerular filtration rate \\\u003C30 ml\u002Fmin\u002Fm2)\n* Inability to understand the study procedure and to sign the study consent",true,"ALL","18 Years","60 Years",{"count":89,"type":90},32,"ESTIMATED","INTERVENTIONAL",[93],"EARLY_PHASE1","The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.",[96],"Overweight and Obesity",[98,99,100,101],"natural odour Inhalation","RCT","Placebo Controlled","Cerebrospinal Fluid","2026-04-28",{"date":104,"type":105},"2026-05-04","ACTUAL",{"date":107,"type":105},"2026-04-14",{"date":109,"type":90},"2027-10-30",{"name":5,"class":6},2]