[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100441163":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":12,"centralContacts":32,"locations":42,"responsibleParty":59,"collaborators":61,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":12,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":12,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":12,"overallStatus":44,"whyStopped":12,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Madigan Army Medical Center","FED",[8,13,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","NO_INTERVENTION","This arm will receive standard of care during dental implant insertion.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Chlorhexidine","EXPERIMENTAL","Chlorhexidine treatment.",[18],"Drug: Chlorhexidine",{"label":20,"type":15,"description":21,"interventionNames":22},"Hydrogen Peroxide","Hydrogen Peroxide treatment.",[23],"Drug: Hydrogen Peroxide",[25,29],{"type":26,"name":14,"description":27,"armGroupLabels":28,"otherNames":12},"DRUG","Chlorhexidine will be inserted into the dental implant internal cavity during dental implant insertion.",[14],{"type":26,"name":20,"description":30,"armGroupLabels":31,"otherNames":12},"Hydrogen Peroxide will be inserted into the internal cavity of the dental implant during dental implant insertion.",[20],[33,38],{"name":34,"role":35,"phone":36,"phoneExt":12,"email":37},"Kevin D Smith, DMD","CONTACT","253-968-0181","kevin.d.smith2.mil@health.mil",{"name":39,"role":35,"phone":40,"phoneExt":12,"email":41},"Zachary T Colburn, PhD","253-968-3455","zachary.t.colburn.civ@health.mil",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Tacoma","Washington","98431","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-122.44429,47.25288,{"lat":54,"lon":53},[57],{"name":58,"role":35,"phone":36,"phoneExt":12,"email":37},"Kevin Smith",{"type":60,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR",[62],{"name":63,"class":6},"United States Department of Defense","100441163","early-phase-1-antiseptic-effects-on-the-dental-implant-internal-surface-microbiome-100441163",false,"NCT05024760","Antiseptic Effects on the Dental Implant Internal Surface Microbiome","Inclusion Criteria:\n\n* Active duty military\n* 18-55 years old\n* Over 6 months remaining at local duty station\n\nExclusion Criteria:\n\n* Tobacco user\n* Medications that affect soft tissue or bone healing\n* Metabolic disorder that affects soft tissue or bone healing\n* Active periodontal disease","ALL","18 Years","55 Years",{"count":74,"type":75},150,"ESTIMATED","INTERVENTIONAL",[78],"EARLY_PHASE1","Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.",[81,82,83,84],"Peri-Implantitis","Peri-implant Mucositis","Implant Infection","Dental Implant Failed","2024-12-19",{"date":87,"type":88},"2024-12-27","ACTUAL",{"date":90,"type":88},"2022-07-28",{"date":92,"type":75},"2025-11",{"name":5,"class":6},1]