[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644665":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":52,"collaborators":25,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":25,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":25,"overallStatus":77,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Cold pressor test","EXPERIMENTAL","Participants will be exposed to the cold pressor test (ice water on the foot).",[13,14],"Drug: Placebo","Drug: Gemtesa",{"label":16,"type":10,"description":17,"interventionNames":18},"Flow Mediated Dilation","Participants will be exposed to the high-resolution ultrasound following inflation of a cuff around the forearm.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Placebo","Participants will receive a placebo in pill form.",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Gemtesa","Participants will receive oral gemtesa (75 mg).",[9,16],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Jacqueline Limberg Associate Professor","CONTACT","1-573-882-2544","limberglab@missouri.edu",[37],{"facility":38,"status":25,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University of Missouri","Columbia","Missouri","65211","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-92.33407,38.95171,{"lat":48,"lon":47},[51],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Jacqueline K Limberg, PhD","Associate Professor","100644665","early-phase-1-beta3-adrenergic-receptors-and-cardiovascular-function-in-aging-women-100644665",false,"NCT07674680","Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women","Inclusion Criteria:\n\nHealthy women Assigned female at birth 18-70 years of age Body mass index \\\u003C18 or ≥30 kg\u002Fm2\n\nExclusion Criteria:\n\nAssigned male at birth Pregnancy Breastfeeding History of hormone replacement therapy, chemical menopause, or oophor-ectomy Polycystic ovarian syndrome or Primary ovarian insufficiency Current smoking\u002FNicotine use Blood pressure ≥140\u002F90 mmHg Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy Nerve\u002Fneurologic disease Cardiovascular, hepatic, renal, respiratory disease Hypersensitivity to nitroglycerin Diabetes Communication barriers",true,"FEMALE","18 Years","70 Years",{"count":67,"type":68},60,"ESTIMATED","INTERVENTIONAL",[71],"EARLY_PHASE1","We hypothesize vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.",[74,75,76],"Women","Aging","Menopause","NOT_YET_RECRUITING","2026-06-23",{"date":80,"type":81},"2026-06-29","ACTUAL",{"date":83,"type":68},"2026-07",{"date":85,"type":68},"2029-05",{"name":5,"class":6},1]