[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100412479":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":21,"centralContacts":55,"locations":64,"responsibleParty":81,"collaborators":21,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":21,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":21,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":21,"overallStatus":105,"whyStopped":21,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,18,23,26,29,32],{"label":9,"type":10,"description":11,"interventionNames":12},"Metabolic diet","PLACEBO_COMPARATOR","Controlled metabolic diet arm.",[13,14,15,16,17],"Drug: Potassium citrate","Drug: Sodium bicarbonate","Dietary Supplement: Litholyte","Dietary Supplement: Crystal Lite","Drug: Potassium Bicarbonate",{"label":19,"type":20,"description":21,"interventionNames":22},"Potassium citrate","ACTIVE_COMPARATOR",null,[13,14,15,16,17],{"label":24,"type":20,"description":21,"interventionNames":25},"Sodium Bicarbonate",[13,14,15,16,17],{"label":27,"type":20,"description":21,"interventionNames":28},"Litholyte arm",[13,14,15,16,17],{"label":30,"type":20,"description":21,"interventionNames":31},"Crystal Lite",[13,14,15,16,17],{"label":33,"type":20,"description":21,"interventionNames":34},"Potassium Bicarbonate",[13,14,15,16,17],[36,40,44,49,52],{"type":37,"name":19,"description":38,"armGroupLabels":39,"otherNames":21},"DRUG","Slow release potassium citrate UroCit-K. Participants will take 20mEq twice daily.",[30,27,9,33,19,24],{"type":37,"name":41,"description":42,"armGroupLabels":43,"otherNames":21},"Sodium bicarbonate","650mg tabs. Take 3 tabs twice daily.",[30,27,9,33,19,24],{"type":45,"name":46,"description":47,"armGroupLabels":48,"otherNames":21},"DIETARY_SUPPLEMENT","Litholyte","One packet is taken with 170ml of water. Two packets daily.",[30,27,9,33,19,24],{"type":45,"name":30,"description":50,"armGroupLabels":51,"otherNames":21},"The classic lemonade contains 21.7mEq\u002Fliter of alkali Therefore, patients will take 2 litres daily to have the 40mEq of alkali daily needed.",[30,27,9,33,19,24],{"type":37,"name":33,"description":53,"armGroupLabels":54,"otherNames":21},"20 mEq tablets, one tablet twice daily",[30,27,9,33,19,24],[56,61],{"name":57,"role":58,"phone":59,"phoneExt":21,"email":60},"Brett A Johnson, MD","CONTACT","214-648-6853","brett.johnson@utsouthwestern.edu",{"name":62,"role":58,"phone":21,"phoneExt":21,"email":63},"Ashley Gonzalez, MD","ashley.gonzalez2@utsouthwestern.edu",[65],{"facility":5,"status":21,"city":66,"state":67,"zip":68,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":76,"contacts":77},"Dallas","Texas","75390","United States","US",{"type":72,"coordinates":73},"Point",[74,75],-96.80667,32.78306,{"lat":75,"lon":74},[78],{"name":79,"role":58,"phone":80,"phoneExt":21,"email":60},"Brett Johnson, MD","2146486853",{"type":82,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","Brett Johnson","Associate Professor of Urology","100412479","early-phase-1-comparing-alkalinizing-agents-efficacy-on-stone-risk-in-patients-on-a-metabolically-controlled-diet-100412479",false,"NCT04651088","Comparing Alkalinizing Agents Efficacy on Stone Risk in Patients on a Metabolically Controlled Diet","Evaluation of Multiple Alkalinizing Agents on Urinary Stone Risk Parameters in Stone and Non-stone Formers on a Metabolically Controlled Diet","Inclusion Criteria:\n\n* Adults aged 18 and older.\n* with or without a history of stone disease.\n\nExclusion Criteria:\n\n* They are unable to take any of the medications due to health reasons.\n* Participants are pregnant or nursing.\n* Participants are unable to adhere to the metabolic diet.\n* Participants had a prior adverse event from one or more of the medications.",true,"ALL","18 Years","90 Years",{"count":97,"type":98},15,"ESTIMATED","INTERVENTIONAL",[101],"EARLY_PHASE1","The purpose of this study is to compare over the counter and alternative prescription urinary alkalinizing agents to slow release potassium citrate in their ability to modify urinary parameters associated with stone formation.",[104],"Kidney Stone","NOT_YET_RECRUITING","2026-02-10",{"date":108,"type":109},"2026-02-13","ACTUAL",{"date":111,"type":98},"2026-07-01",{"date":113,"type":98},"2027-07",{"name":5,"class":6},1]