[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633774":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":29,"responsibleParty":48,"collaborators":11,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":11,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":11,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":32,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cryotherapy followed by intralesional injection of 5-FU","EXPERIMENTAL",null,[13],"Drug: Cryotherapy will be done followed by intralesional injection of 5-fluorouracil",{"label":15,"type":16,"description":11,"interventionNames":17},"Intralesional injection of 5-FU","ACTIVE_COMPARATOR",[18],"Drug: Intralesional 5-fluorouracil",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Cryotherapy will be done followed by intralesional injection of 5-fluorouracil","Cryotherapy will be done followed by intralesional injection of 5-FU diluted in steroid, this will be done in phases. Not more than 150mg 5-FU will be used during each session. Session will be repeated after every 3 week for 6 months.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Intralesional 5-fluorouracil","intralesional 5-FU will be given in phases. sessions will be repeated after every 3 weeks for 6 months",[15],[30],{"facility":31,"status":32,"city":33,"state":11,"zip":11,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"CMH Bahawalpur","RECRUITING","Chak Four Hundred Fifty-four","Pakistan","PK",{"type":37,"coordinates":38},"Point",[39,40],72.44769,31.26081,{"lat":40,"lon":39},[43],{"name":44,"role":45,"phone":46,"phoneExt":11,"email":47},"Areeba Sadia","CONTACT","+923336881616","areebasadiahadia@gmail.com",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Sara Khan","Principal Investigator","100633774","early-phase-1-comparison-of-effectiveness-of-intralesional-injectioms-of-5-flourouracil-alone-verses-its-cpmbination-with-cryotherapy-in-the-treatment-of-keloids-100633774",false,"NCT07531056","Comparison Of Effectiveness Of Intralesional Injectioms Of 5 Flourouracil Alone Verses Its Cpmbination With Cryotherapy In The Treatment Of Keloids","A Randomized Controlled Trial Comparing The Effectiveness And Safety Of iIntralesional 5 Flourouracil Monotherapy Verses 5 Flourouracil Combined With Cryotherapy; In The Treatment Of Keloid Scars","Inclusion Criteria:\n\n* Patients willing to participate in the study\n* Patients of age group of 18 -50 years.\n* Patients having symptomatic keloids i.e., having pain, pruritus, restriction of movement, scar tension or disfigurement.\n\nExclusion Criteria\n\n:• Pregnant women or lactating women\n\n* Patients with history of hepatic, renal, cardiac diseases or chronic diarrhea.\n* Patients on immunosuppressant medications due to other diseases\n* Patients having myelosuppression checked by CBC.\n* Patient taking warfarin.\n* Patients with history of hypersensitivity to 5FU.","ALL","18 Years","50 Years",{"count":63,"type":64},88,"ESTIMATED","INTERVENTIONAL",[67],"EARLY_PHASE1","The goal of this clinical trial is to learn how well intralesional 5 fluorouracil with cryotherapy works to treat keloids as compared to intralesional 5 fluorouracil alone on keloids. It will also learn about the safety of both these treatments. The main questions it aims to answer are:\n\n* What well does cryotherapy followed by intralesional 5 fluorouracil (5FU) work to treat keloids as compared to 5 fluorouracil (5FU) alone?\n* What is participant's satisfaction when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) as compared to 5 fluorouracil (5FU) alone?\n* What skin problems do participants have when treated with cryotherapy followed by intralesional 5 fluorouracil (5FU) and 5 fluorouracil (5FU) alone? Researchers will compare cryotherapy followed by intralesional 5 fluorouracil (5FU) with 5 fluorouracil (5FU) alone to see how well both work.\n\nParticipants will be divided into two groups:\n\nFor Group A: Cryotherapy will be done at lesion site followed by intralesional 5FU every 3 weekly.\n\nFor Group B: Intralesional 5FU will be given at lesion site every 3 weekly. Keloids will be assessed at the start of trial and then after 12 weeks of treatment.",[70],"Keloids",[70,72,73],"Intralesional injectioms","5-FU","2026-04-21",{"date":76,"type":77},"2026-04-24","ACTUAL",{"date":79,"type":77},"2025-12-22",{"date":81,"type":64},"2026-09-20",{"name":5,"class":6},1]