[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556957":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":37,"centralContacts":41,"locations":50,"responsibleParty":69,"collaborators":27,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":27,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":27,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":27,"overallStatus":53,"whyStopped":27,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Auburn University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Curcumin and EGCG Supplementation","EXPERIMENTAL","Participants in the intervention group with consume 1,330mg\u002Fday curcumin with 350mg\u002Fday EGCG.",[13,14],"Dietary Supplement: Curcumin","Dietary Supplement: Epigallocatechin Gallate",{"label":16,"type":17,"description":18,"interventionNames":19},"Placebo","PLACEBO_COMPARATOR","Participants will receive a placebo to consume everyday.",[20],"Other: Placebo",[22,28,34],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DIETARY_SUPPLEMENT","Curcumin","1,330 mg curcumin",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Epigallocatechin Gallate","350 mg Epigallocatechin gallate (EGCG)",[9],[33],"EGCG",{"type":6,"name":16,"description":35,"armGroupLabels":36,"otherNames":27},"Placebo to be consumed after randomization.",[16],[38],{"name":39,"affiliation":5,"role":40},"Andrew D Fruge, PhD","PRINCIPAL_INVESTIGATOR",[42,47],{"name":43,"role":44,"phone":45,"phoneExt":27,"email":46},"Aidan Cavanah, MSc","CONTACT","2057893258","amc0108@auburn.edu",{"name":48,"role":44,"phone":27,"phoneExt":27,"email":49},"Andrew Fruge, PhD","adf0003@auburn.edu",[51],{"facility":52,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Auburn University School of Kinesiology","RECRUITING","Auburn","Alabama","36849","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-85.48078,32.60986,{"lat":63,"lon":62},[66],{"name":67,"role":44,"phone":68,"phoneExt":27,"email":49},"Drew Fruge, PhD","3448448433",{"type":40,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Aidan Cavanah","Graduate Assistant","100556957","early-phase-1-curcumin-and-egcg-supplementation-to-improve-serum-bdnf-and-mood-disturbance-100556957",false,"NCT06531863","Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance","A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin Gallate Supplementation on Serum Brain Derived Neurotrophic Factor and Mood Disturbance in Adults","Inclusion Criteria:\n\n* Adults age 18-50\n* Depression subscale score of \\>9\u002F21 on the DASS-21\n* No change in medications or supplements over the past 3 months\n* Can read and speak English\n\nExclusion Criteria:\n\n* Currently consume curcumin or green tea daily\n* Currently, pregnant, nursing, or trying to become pregnant\n* Currently diagnosed with a perimenopausal disorder",true,"ALL","18 Years","50 Years",{"count":84,"type":85},64,"ESTIMATED","INTERVENTIONAL",[88],"EARLY_PHASE1","The goal of this randomized placebo controlled trial is to examine mood disturbance and serum brain derived neurotrophic factor (BDNF) in people (age 18-50) with DASS-21 subscale scores \\>9. The main questions it aims to answer are:\n\nDoes curcumin and EGCG supplementation improve mood disturbance symptomology? Does curcumin and EGCG supplementation increase serum BDNF? Researchers will compare intervention versus placebo.\n\nParticipants will consume an 8-week supplement of both:\n\n* 1,330mg\u002Fday curcumin\n* 350mg\u002Fday epigallocatechin gallate (EGCG)",[91],"Mood Disturbance","2025-02-13",{"date":94,"type":95},"2025-02-14","ACTUAL",{"date":97,"type":95},"2024-09-30",{"date":99,"type":85},"2025-08-01",{"name":5,"class":6},1]