[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100418065":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":42,"responsibleParty":67,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":25,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of Virginia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Spironolactone","EXPERIMENTAL","Prior to the first or second admission (randomly determined), participants will be pretreated for 2 weeks with spironolactone (50 mg twice daily).",[13],"Drug: Spironolactone",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Prior to the first or the second admission (randomly determined), participants will be pretreated for 2 weeks with placebo (twice daily).",[19],"Drug: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Spironolactone is an androgen-receptor blocker commonly used (off-label) for hyperandrogenism. The spironolactone dose will be 50 mg taken orally twice daily (for two weeks before admission to the Clinical Research Unit).",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Placebo contains only inert ingredients and is not expected to exert any direct physiological effects.",[15],[30],{"name":31,"affiliation":32,"role":33},"Christine Burt Solorzano, MD","University of Virginia Center for Research in Reproduction","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Melissa Gilrain, BS","CONTACT","434-243-6911","mg7zb@hscmail.mcc.virginia.edu",{"name":31,"role":37,"phone":38,"phoneExt":25,"email":41},"cmb6w@hscmail.mcc.virginia.edu",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Center for Research in Reproduction, University of Virginia","RECRUITING","Charlottesville","Virginia","22908","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-78.47668,38.02931,{"lat":55,"lon":54},[58,60,63,64],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":59},"pcos@virginia.edu",{"name":61,"role":37,"phone":62,"phoneExt":25,"email":59},"Christine M Burt Solorzano, MD","434-924-9084",{"name":61,"role":33,"phone":25,"phoneExt":25,"email":25},{"name":65,"role":66,"phone":25,"phoneExt":25,"email":25},"Christopher R McCartney, MD","SUB_INVESTIGATOR",{"type":33,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Christine Burt Solorzano","Assistant Professor in Pediatrics",[71],{"name":72,"class":73},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH","100418065","early-phase-1-does-spironolactone-normalize-sleep-wake-luteinizing-hormone-pulse-frequency-in-pubertal-girls-with-hyperandrogenism-100418065",false,"NCT04723862","Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?","Does Spironolactone Normalize Sleep-wake Luteinizing Hormone (LH) Pulse Frequency in Pubertal Girls With Hyperandrogenism? (CBS010)","CBS010","Inclusion Criteria:\n\n* Mid- to late pubertal adolescent girls as signified by either (a) post-menarcheal status (Tanner breast stages 2-5) or (b) Tanner breast stage of 4 or 5 (whether pre-menarcheal or post-menarcheal) ages 10-17 years.\n* Hyperandrogenism, defined as a serum (calculated) free testosterone concentration greater than the Tanner stage-specific reference range and\u002For clinical hirsutism\n* General good health (excepting obesity, hyperandrogenism, PCOS, and adequately-treated hypothyroidism)\n* Willing to strictly avoid pregnancy with use of reliable non-hormonal methods during the study period.\n\nExclusion Criteria:\n\n* Inability\u002Fincapacity to provide informed consent\n* Males will be excluded (hyperandrogenism is unique to females)\n* Age \\\u003C 10 or \\> 17 years (this study is designed to elucidate mechanisms underlying emerging PCOS in mid- to late pubertal adolescent girls\n* Post-menarcheal by \\> 4 years\n* Obesity resulting from a well-defined endocrinopathy, or genetic syndrome\n* To ensure that blood withdrawal is within safe limits, weight \\\u003C 21.5 kg is an exclusion criterion.\n* Since underweight can alter pulsatile LH secretion, BMI-for-age percentile \\\u003C 5 is an exclusion criterion.\n* Positive pregnancy test or current lactation. Subjects with a positive pregnancy test will be informed of the result by the screening physician. Under Virginia law, parental notification is not required for minors. However, the screening physician will encourage the subject to tell her parent(s). We will counsel the adolescent about the importance of appropriate prenatal care\u002Fcounseling. We will offer appropriate follow-up at the Teen Health Clinic at UVA and\u002For encourage the adolescent to secure prompt care via their primary care physician's office.\n* Evidence for non-physiologic or non-PCOS causes of hyperandrogenism and\u002For anovulation\n* Evidence of virilization (e.g., rapidly progressive hirsutism, deepening of the voice, clitoromegaly)\n* Total testosterone \\> 150 ng\u002Fdl, which suggests the possibility of virilizing ovarian or adrenal tumor.\n* DHEA-S elevation \\> 1.5 times the upper reference range limit. Mild elevations may be seen in adolescent HA and in PCOS, and will be accepted in these groups.\n* Early morning 17-hydroxyprogesterone \\> 300 ng\u002Fdl measured in the follicular phase, which suggests the possibility of congenital adrenal hyperplasia (if elevated during the luteal phase, the 17-hydroxyprogesterone will be repeated during the follicular phase). NOTE: if a 17-hydorxyprogesterone \\> 300 ng\u002Fdl is confirmed on repeat testing, an ACTH stimulated 17-hydroxyprogesterone \\\u003C 1000 ng\u002Fdl performed by the subject's personal physician will be required for study participation.\n* Any abnormal TSH concentration will trigger repeat testing. In many cases when TSH is initially abnormal, a repeat TSH will be normal. These subjects will be permitted to continue study. If TSH remains abnormal on repeat testing, the subject will be referred to her primary medical provider. In some cases, a participant's primary medical provider will elect to simply observe a mildly low (\\> 0.1) or mildly elevated (\\\u003C 10) if stable. In such cases, we will accept a TSH between 0.3 and 7 (inclusive) if it has remained stable for at least 6 months-such TSH values are exceedingly unlikely to influence the central reproductive axis or to influence the risks of the study. Notably, subjects with reasonably-treated primary hypothyroidism-reflected by TSH values between 0.3 and 7-on a stable dose of thyroid hormone (i.e., same dose for at least 2 months) will not be excluded.\n* Prolactin concentration \\> 30 ng\u002FmL (confirmed on repeat). Mild prolactin elevations may be seen in adolescents and women with HA\u002FPCOS or obesity.\n* History and\u002For physical exam findings suggestive of Cushing's syndrome, adrenal insufficiency, or acromegaly.\n* History and\u002For physical exam findings suggestive of hypogonadotropic hypogonadism (e.g., symptoms of estrogen deficiency) including functional hypothalamic amenorrhea (which may be suggested by a constellation of symptoms including restrictive eating patterns, excessive exercise, psychological stress, etc.)\n* Persistent hemoglobin \\\u003C 11.5 g\u002FdL for non-African American subjects; hemoglobin \\\u003C 11.0 g\u002FdL for African American subjects (confirmed on repeat). Importantly, documentation of a hemoglobin ≥ 11.0 g\u002FdL for African American subjects or ≥ 11.5 g\u002FdL for non-African American subjects in the month prior to the CRU admission is required for frequent sampling protocol in the CRU.\n* Severe thrombocytopenia (platelets \\\u003C 50,000 cells\u002Fmicroliter) or leukopenia (total white blood count \\\u003C 4,000 cells\u002Fmicroliter)\n* Previous diagnosis of diabetes, fasting glucose ≥ 126 mg\u002Fdl, or a hemoglobin A1c ≥ 6.5%\n* Persistently abnormal sodium or potassium concentration. Bicarbonate concentrations \\\u003C 20 or \\> 30.\n* Liver test abnormalities, with two exceptions: (1) mild bilirubin elevations will be accepted in the setting of known Gilbert's syndrome or when the subject's primary care provider provides a presumptive diagnosis of Gilbert's syndrome and has no plans for further work-up; (2) mild transaminase (ALT, AST) elevations may be seen in obese\u002FHA\u002FPCOS girls, so stable elevations \\\u003C 1.5 times the upper limit of normal will be accepted in this group.\n* Absolute contraindications to spironolactone use include history of allergy to spironolactone, anuria, acute renal insufficiency, significant impairment of renal excretory function, hyperkalemia, primary adrenal insufficiency (Addison's disease), and concomitant use of eplerenone\n* Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected congestive heart failure, asthma requiring intermittent systemic corticosteroids, etc.)\n* Decreased renal function evidenced by GFR \\\u003C 60 ml\u002Fmin\u002F1.73m2\n* History of cancer diagnosis and\u002For treatment (with the exception of basal cell or squamous cell skin carcinoma) unless they have remained clinically disease free (based on appropriate surveillance) for five years.",true,"FEMALE","10 Years","17 Years",{"count":87,"type":88},32,"ESTIMATED","INTERVENTIONAL",[91],"EARLY_PHASE1","The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary endpoint) and overall LH and follicle-stimulating hormone secretion (secondary endpoints).",[94,95,96],"Hyperandrogenism","Polycystic Ovary Syndrome","Puberty",[94,98,96],"Polycystic ovary syndrome","2025-07-30",{"date":101,"type":102},"2025-08-05","ACTUAL",{"date":104,"type":102},"2021-11-12",{"date":106,"type":88},"2025-12-01",{"name":5,"class":6},1]