[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599591":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":43,"responsibleParty":59,"collaborators":31,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":31,"enrollmentInfo":72,"targetDuration":31,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":45,"whyStopped":31,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Beirut Arab University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Collagen sponge","ACTIVE_COMPARATOR","Participants will be treated with collagen sponge at the palatal donor wound to achieve hemostasis. After FGG harvest, pressure will be applied at the palatal wound using a gauze soaked in saline to top the bleeding, then a collagen sponge will be placed and stabilized with 4\u002F0 silk (x) sutures.",[13],"Device: Collagen sponge",{"label":15,"type":16,"description":17,"interventionNames":18},"Cyanoacrylate tissue adhesive","EXPERIMENTAL","Participants will be treated with cyanoacrylate tissue adhesive (PeriAcryl) at the palatal donor wound to achieve hemostasis. After FGG harvest, pressure will be applied at the palatal wound using a gauze soaked in saline to top the bleeding, then PeriAcryl will be applied with a pipette following manufacturer's instructions on the entire area of the wound.",[19],"Combination Product: Cyanoacrylate tissue adhesive",[21,27],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"COMBINATION_PRODUCT","Cyanoacrylate tissue adhesive is a chemical synthetic and hybrid tissue sealant possessing strong, rapid acting adhesive properties and is often used in general surgery. Recently, cyanoacrylate tissue adhesive has been effectively introduced into dentistry to close wounds and stop ischemic areas from forming in periodontal aesthetic surgeries. As well as in exposed membranes to preserve the bone graft after guided bone regeneration, in post-extraction sockets, and to seal any surgical flap. This material has strong hemostatic, bacteriostatic, and sealing qualities.",[15],[26],"PeriAcryl",{"type":28,"name":9,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","Collagen sponge is an organic polymer that promotes the development of blood clots, and it resorbs quickly and completely over time. Collagen sponge create a matrix at the bleeding site, encourage platelet activation and aggregation, and engage the extrinsic coagulation pathway. Thus, it can be utilized as the first choice for wound healing.",[9],null,[33],{"name":34,"affiliation":35,"role":36},"Nayer Aboelsaad","Professor","STUDY_CHAIR",[38],{"name":39,"role":40,"phone":41,"phoneExt":31,"email":42},"Dania EL Rostom, MSc Oral and Dental Surgery","CONTACT","+96171659355","daniarostom1999@hotmail.com",[44],{"facility":5,"status":45,"city":46,"state":31,"zip":31,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Beirut","Lebanon","LB",{"type":50,"coordinates":51},"Point",[52,53],35.50157,33.89332,{"lat":53,"lon":52},[56],{"name":34,"role":40,"phone":57,"phoneExt":31,"email":58},"+96179109899","n.mohamedaboelsaad@bau.edu.lb",{"type":60,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100599591","early-phase-1-effect-of-cyanoacrylate-tissue-adhesive-versus-collagen-sponge-on-palatal-donor-site-healing-100599591",false,"NCT07086482","Effect of Cyanoacrylate Tissue Adhesive Versus Collagen Sponge on Palatal Donor Site Healing","Effect of Cyanoacrylate Tissue Adhesive Versus Collagen Sponge on Palatal Donor Site Healing After Harvesting a Free Gingival Graft: a Randomized Controlled Clinical Trial","RCT","Inclusion Criteria:\n\n* Low-moderate anesthetic risk (ASA I-II)\n* No restriction on ethnicity or gender\n* Patients requiring FGG from the palate for periodontal plastic surgery\n* Clinically healthy gingiva after phase I therapy\n* Full-mouth plaque index grades 0 and 1\n* Bleeding scores \\\u003C15%\n\nExclusion Criteria:\n\n* Patients who smoke \\> 10 cigarettes\u002Fday\n* Patients with coagulation disorders\n* Systemic diseases\n* Patients on certain medications that may affect periodontal tissues\n* Pregnant and lactating patient\n* Patients with allergies to drugs that will be prescribed during the treatment phase\n* Pathological mental conditions (dementia, psychosis) and lack of cooperation\n* Excessive gag reflex",true,"ALL","18 Years",{"count":73,"type":74},22,"ESTIMATED","INTERVENTIONAL",[77],"EARLY_PHASE1","The goal of this clinical trial is to learn if the use of cyanoacrylate glue (PeriAcryl) is effective in healing of the palatal donor site in adults requiring a free gingival graft.\n\nThe main question\\[s\\] it aims to answer \\[is\u002Fare\\]:\n\nDoes PeriAcryl accelerate the palatal tissue healing compared with the use of collagen sponge? Does PeriAcryl usage leave the patients more satisfied?\n\nResearcher will compare the outcomes of participants treated with PeriAcryl to those treated with collagen sponge to see if PeriAcryl accelerated the healing process of palatal tissues and led to fewer postoperative complications.\n\nParticipants will:\n\n* be assigned to a study group using PeriAcryl or control group using Collagen sponge.\n* be followed-up to monitor healing and gather clinical information.",[80],"Palate; Wound",[82,83,84,85],"palatal donor area","Cyanoacrylate glue","wound healing","free gingival graft","2025-08-13",{"date":88,"type":89},"2025-08-17","ACTUAL",{"date":91,"type":89},"2025-08-04",{"date":93,"type":74},"2026-04-20",{"name":5,"class":6},1]