[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601343":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":40,"locations":46,"responsibleParty":63,"collaborators":31,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":31,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":31,"enrollmentInfo":76,"targetDuration":31,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":49,"whyStopped":31,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A","EXPERIMENTAL","They will receive one dose of IM dexamethasone sodium phosphate 8 mg (2 mL).",[13],"Drug: Dexamethasone (Decadron) 8mg IM injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B","ACTIVE_COMPARATOR","They will receive vaginal misoprostol 25 μg tablets every 6 h, up to 4 tablets, for a maximum duration of 24 h.",[19],"Drug: Misoprostol 25 mcg",{"label":21,"type":10,"description":22,"interventionNames":23},"Group C","They will receive one dose of IM dexamethasone sodium phosphate 8mg (2mL) with the first dose of vaginal misoprostol 25 μg tablets that will be given every 6 h, up to 4 tablets, for a maximum duration of 24 h.",[24],"Drug: Both Misoprostol 25 mcg & Dexamethasone 8mg IM injection",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Dexamethasone (Decadron) 8mg IM injection","one dose of IM dexamethasone sodium phosphate 8 mg (2 mL) given at the start of labour induction",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Misoprostol 25 mcg","vaginal misoprostol 25 μg tablets every 6 h, up to 4 tablets, for a maximum duration of 24 h.",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Both Misoprostol 25 mcg & Dexamethasone 8mg IM injection","one dose of IM dexamethasone sodium phosphate 8mg (2mL) with the first dose of vaginal misoprostol 25 μg tablets that will be given every 6 h, up to 4 tablets, for a maximum duration of 24 h.",[21],[41],{"name":42,"role":43,"phone":44,"phoneExt":31,"email":45},"Abdelfatah M Eldesouky, MD, MRCOG","CONTACT","00201003370784","a.f.dessouki@gmail.com",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Cairo University Hospital (Kasr Al Ainy)","RECRUITING","Cairo","Manial","11562","Egypt","EG",{"type":56,"coordinates":57},"Point",[58,59],31.24967,30.06263,{"lat":59,"lon":58},[62],{"name":42,"role":43,"phone":44,"phoneExt":31,"email":45},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Abdelfatah Mohamed Kamel Eldesouky","Lecturer of Obstetrics and Gynecology","100601343","early-phase-1-effect-of-dexamethasone-on-labour-induction-in-term-pregnancies-100601343",false,"NCT07109258","Effect of Dexamethasone on Labour Induction in Term Pregnancies","Inclusion Criteria:\n\n* Age \\> 18 years.\n* Nulliparous.\n* Vertex presentation.\n* Singleton pregnancy.\n* Gestational age ≥ 39 weeks according to a reliable date for the last menstrual period or a first-trimester ultrasound evaluation.\n* No contraindication for vaginal delivery.\n\nExclusion Criteria:\n\n* Indication for cesarean section e. g. Placenta previa, intrauterine growth retardation, non-vertex presentation and previous cesarean section.\n* Maternal medical disorders as diabetes mellitus and severe pre-eclampsia.\n* Preterm labour and preterm rupture of membranes.\n* Gestational age \\\u003C39 weeks of gestation.\n* Fetal macrosomia \\> 4kg (estimated by u\u002Fs).",true,"FEMALE","18 Years",{"count":77,"type":78},150,"ESTIMATED","INTERVENTIONAL",[81],"EARLY_PHASE1","The aim of the study is to assess the effect of dexamethasone on labour induction in term pregnancies.\n\nPrimary outcome:\n\nThe interval between initiation of induction and beginning of the active phase of labour.\n\nSecondary outcomes:\n\n* Duration of active phase of labour (starting with cervical dilatation of 4-5 cm up to full cervical dilatation).\n* Duration of second stage of labour\n* Mode of delivery.\n* Fetal outcome.\n\nGroup A:\n\nWill receive one dose of IM dexamethasone sodium phosphate 8 mg (2 mL).\n\nGroup B:\n\nWill receive vaginal misoprostol 25 μg tablets every 6 h, up to 4 tablets, for a maximum duration of 24 h.\n\nGroup C:\n\nWill receive one dose of IM dexamethasone sodium phosphate 8mg (2mL) with the first dose of vaginal misoprostol 25 μg tablets that will be given every 6 h, up to 4 tablets, for a maximum duration of 24 h.",[84],"Labor Induction",[84,86,87,88],"Dexamethasone","Misoprostol","Term pregnancies","2025-07-31",{"date":91,"type":92},"2025-08-07","ACTUAL",{"date":94,"type":92},"2025-05-01",{"date":96,"type":78},"2025-09-15",{"name":5,"class":6},1]