[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100529089":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":53,"collaborators":24,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":24,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":24,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":79,"overallStatus":37,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"National Institute of Cardiology, Laranjeiras, Brazil","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","The placebo group will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.",[13],"Dietary Supplement: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Beetroot extract","ACTIVE_COMPARATOR","Beetroot extract powder supplementation with 400mg of nitrate per dose in the amount of 10g per day orally will be used in the group.",[19],"Dietary Supplement: Beetroot extract",[21,25],{"type":22,"name":15,"description":17,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT",[15],null,{"type":22,"name":9,"description":26,"armGroupLabels":27,"otherNames":24},"The placebo will be administered as a colored and flavored isocaloric supplement composed of maltodextrin.",[9],[29],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"EDUARDO TIBIRICA, MD, PhD","CONTACT","+55-21-99914-6075","etibi@uol.com.br",[35],{"facility":36,"status":37,"city":38,"state":24,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"National Institute of Cardiology","RECRUITING","Rio de Janeiro","21040-360","Brazil","BR",{"type":43,"coordinates":44},"Point",[45,46],-43.18223,-22.90642,{"lat":46,"lon":45},[49],{"name":50,"role":31,"phone":51,"phoneExt":24,"email":52},"Eduardo Tibirica","2125921265","eitib@uol.com.br",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Eduardo Tibirica, MD, PhD","Senior Researcher","100529089","early-phase-1-effect-of-nitrate-supplementation-on-blood-pressure-and-microvascular-function-of-resistant-hypertensive-patients-100529089",false,"NCT06169241","Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients","Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients","Inclusion Criteria:\n\n* Resistant hypertension, with a diagnosis described in the medical record, without changing medications or increasing doses in the last 30 days.\n\nExclusion Criteria:\n\n* neoplasms\n* heart failure\n* use of medications with nitrate in their formula\n* patients undergoing renal denervation","ALL","18 Years","75 Years",{"count":68,"type":69},50,"ESTIMATED","INTERVENTIONAL",[72],"EARLY_PHASE1","Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.",[75,76,77,78],"Arterial Hypertension","Resistant Hypertension","Microvascular Function","Nitrate Supplementation",[80,81,82,83],"microcirculation","capillary density","microvascular reactivity","systemic resistant hypertension","2026-04-07",{"date":86,"type":87},"2026-04-13","ACTUAL",{"date":89,"type":87},"2023-11-01",{"date":91,"type":69},"2026-12",{"name":5,"class":6},1]