[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623605":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":29,"responsibleParty":48,"collaborators":11,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":11,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":11,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":32,"whyStopped":11,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Microneedling with topical 5-fluorouracil","EXPERIMENTAL",null,[13],"Drug: Microneedling with 5-fluorouracil",{"label":15,"type":16,"description":11,"interventionNames":17},"Clobetasol propionate 0.05%","ACTIVE_COMPARATOR",[18],"Drug: Topical application of 0.05% Clobetasol propionate",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Microneedling with 5-fluorouracil","Micro-needling will be done, 2 passes will be made on the affected patch of vitiligo with 5 FU. Not more than 0.5 ml 5FU will be used during each session. Session will be repeated 2 weekly for 6 months.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Topical application of 0.05% Clobetasol propionate","Topical 0.05% clobetasol propionate ointment will be applied twice a day on the vitiligo patches.1 finger-tip unit (FTU) will be used for 2% BSA i.e., 0.5 grams.",[15],[30],{"facility":31,"status":32,"city":33,"state":11,"zip":11,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"CMH Bahawalpur","RECRUITING","Chak Four Hundred Fifty-four","Pakistan","PK",{"type":37,"coordinates":38},"Point",[39,40],72.44769,31.26081,{"lat":40,"lon":39},[43],{"name":44,"role":45,"phone":46,"phoneExt":11,"email":47},"KAINAT TARIQ","CONTACT","03314030300","kainattariq555111@gmail.com",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Sara Khan","Principal investigator","100623605","early-phase-1-effectiveness-of-micro-needling-with-5-fluorouracil-versus-potent-topical-steroids-in-the-treatment-of-limited-vitiligo-100623605",false,"NCT07398807","Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo","Effectiveness of Combining Micro Needling With 5 Fluorouracil Versus Potent Topical Steroids; in Treating Limited Vitiligo- Randomised Controlled Study","Inclusion Criteria:\n\n* Patients willing to participate in the study\n* Patients of age group of 05 -70 years.\n* Vitiligo involving less than or equal to 10% body surface area.\n\nExclusion Criteria:\n\n* Patients using or have used other treatments for vitiligo\n* Pregnant women or lactating women\n* Patients with unstable vitiligo\n* Patients on immunosuppressant medications due to other diseases\n* Patients having anemia, immunosuppression, bleeding disorder, taking anticoagulants or anti-platelet drugs or having epilepsy\n* Patient having history of keloids or hypertrophic scars\n* Patients with history of hypersensitivity to either of the drugs","ALL","4 Years","70 Years",{"count":63,"type":64},40,"ESTIMATED","INTERVENTIONAL",[67],"EARLY_PHASE1","The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin. It will also learn about the safety of both these treatments. The main questions it aims to answer are:\n\n* How well does 5FU with microneedling work to treat vitiligo by returning pigmentation in vitiligo patches as compared to steroid?\n* What is participant's satisfaction when treated with 5FU with microneedling as compared to steroid?\n* What skin problems do participants have when treated with FU with microneedling and steroid?\n\nResearchers will compare 5FU with microneedling to steroid application to see how well both work to return pigment in vitiligo patches.\n\nParticipants will be divided into two groups. For Group A, 5 FU will be rubbed and absorbed on the vitiligo patch after micro-needling every 2 weeks.\n\nFor group B, topical 0.05% clobetasol propionate ointment will be applied twice a day on the vitiligo patches for 12 weeks.\n\nVitiligo patches will be assessed at the start of trial and then after 12 weeks of treatment.",[70],"Vitiligo",[70,72,73,74],"Limited","Microneedling","5-FU","2026-02-12",{"date":77,"type":78},"2026-02-17","ACTUAL",{"date":80,"type":78},"2025-08-08",{"date":82,"type":64},"2026-02",{"name":5,"class":6},1]