[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564872":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":62,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":26,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","Placebo injection into deltoid (arm)",[13],"Drug: Saline injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Steroid","EXPERIMENTAL","Triamcinolone injection into deltoid (arm)",[19],"Drug: Triamcinolone Acetonide Injectable Suspension",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Triamcinolone Acetonide Injectable Suspension","Triamcinolone injection into deltoid muscle (arm)",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Saline injection","Saline injection into deltoid muscle (arm)",[9],[32],{"name":33,"affiliation":5,"role":34},"Lauren Howser","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Kirsten Meenan","CONTACT","843-792-6755","meenan@musc.edu",{"name":33,"role":38,"phone":39,"phoneExt":26,"email":42},"howser@musc.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Charleston","South Carolina","29403","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-79.93275,32.77632,{"lat":55,"lon":54},[58,60],{"name":59,"role":38,"phone":39,"phoneExt":26,"email":42},"Laryngology Office",{"name":61,"role":34,"phone":26,"phoneExt":26,"email":26},"Lauren Howser, MD",{"type":34,"investigatorFullName":33,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Principal Investigator","100564872","early-phase-1-efficacy-of-intramuscular-steroid-injection-for-chronic-cough-100564872",false,"NCT06634823","Efficacy of Intramuscular Steroid Injection for Chronic Cough.","Prospective Placebo-Controlled Trial of Intramuscular Steroid Administration for the Treatment of Unexplained Chronic Cough","Inclusion Criteria:\n\n* History consistent with chronic unexplained or refractory cough\n* Age ≥ 18\n\nExclusion Criteria:\n\n* Current smokers\n* Uncontrolled diabetes (A1c\\>7%)\n* Patients on ACE inhibitors or Angiotensin II receptor blockers (ARBs)\n* Abnormal pulmonary function testing (PFTs) since start of the cough\n* Patients with uncontrolled obstructive sleep apnea\n* Abnormal chest X-ray within past 6 months\n* Uncontrolled reflux\n* Prior superior laryngeal nerve injection\n* Current neuromodulating medication use for chronic cough\\*","ALL","18 Years",{"count":74,"type":75},40,"ESTIMATED","INTERVENTIONAL",[78],"EARLY_PHASE1","The primary goal of this study is to test the hypothesis that injecting steroid intramuscularly is an effective treatment for unexplained chronic cough. This will be achieved through the design of a prospective, placebo-controlled, single-blind, randomized clinical trial in which one group of patients will undergo a steroid injection into the deltoid muscle and the second group will undergo a placebo injection into the deltoid muscle. Data to determine if a clinically significant difference exists between the outcomes of the two groups will be measured by a dichotomous yes\u002Fno response to improvement, the Leicester Cough Questionnaire, and a visual analogue scale for symptom severity. This will provide the answer to the general question of whether or not the intramuscular injections are clinically effective for patients with unexplained chronic cough. Furthermore, any adverse reactions will be thoroughly documented. If this hypothesized treatment is proven effective, this can greatly improve the care of chronic cough patients by allowing for an evidence-based treatment option and a treatment option that may improve access to care. While the superior laryngeal nerve (SLN) injection is typically performed by fellowship trained laryngologists, intramuscular injections could be more widely utilized by general otolaryngologists or providers in other fields of medicine.",[81,82,83],"Chronic Cough (CC)","Laryngeal Disease","Coughing",[85,86,87,88],"Throat","Chronic cough","Neurogenic cough","Unexplained cough","2025-07-09",{"date":91,"type":92},"2025-07-14","ACTUAL",{"date":94,"type":92},"2024-12-02",{"date":96,"type":75},"2026-06-30",{"name":5,"class":6},1]