[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569416":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":33,"centralContacts":39,"locations":45,"responsibleParty":69,"collaborators":72,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":33,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":33,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":48,"whyStopped":33,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Washington State University","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1: oregano alone","EXPERIMENTAL","6 participants will be administered 180 mg of a well-characterized oregano product. Blood will be drawn via an indwelling venous catheter immediately before and at 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, and 24 hours after administration of oregano. Urine will be collected in multiple jugs for 24 hours.",[13],"Dietary Supplement: Oregano",{"label":15,"type":10,"description":16,"interventionNames":17},"Arm 2: drug cocktail alone","16 participants, which may or may not include any number of the original 6 from Arm 1, will be administered an oral drug cocktail consisting of caffeine (100 mg), dextromethorphan (30 mg), losartan (25 mg), midazolam syrup (2 mg), and omeprazole (20 mg). Blood and urine will be collected in the same manner described in Arm 1.",[18],"Drug: Drug cocktail",{"label":20,"type":10,"description":21,"interventionNames":22},"Arm 3: acute oregano + cocktail","The same 16 participants will be administered the oregano product and the drug cocktail. Blood and urine will be collected in the same manner described in Arm 1.",[13,18],{"label":24,"type":10,"description":25,"interventionNames":26},"Arm 4: chronic oregano + cocktail","The same 16 participants will self-administer the oregano product at home for 5 consecutive days. On day 6, participants will return to the study setting, where the procedure described in Arm 3 will be repeated.",[13,18],[28,34],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DIETARY_SUPPLEMENT","Oregano","Oil of oregano administered as a softgel (180 mg).",[9,20,24],null,{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":33},"DRUG","Drug cocktail","Oral drug cocktail consisting of caffeine (100 mg), dextromethorphan (30 mg), losartan (25 mg), midazolam syrup (2 mg), and omeprazole (20 mg).",[15,20,24],[40],{"name":41,"role":42,"phone":43,"phoneExt":33,"email":44},"Mary F Paine, RPh, PhD","CONTACT","509-358-7759","mary.paine@wsu.edu",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Washington State University College of Pharmacy and Pharmaceutical Sciences","RECRUITING","Spokane","Washington","99202","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-117.42908,47.65966,{"lat":58,"lon":57},[61,62,64,67],{"name":41,"role":42,"phone":43,"phoneExt":33,"email":44},{"name":41,"role":63,"phone":33,"phoneExt":33,"email":33},"PRINCIPAL_INVESTIGATOR",{"name":65,"role":66,"phone":33,"phoneExt":33,"email":33},"Matthew Layton, MD, PhD","SUB_INVESTIGATOR",{"name":68,"role":66,"phone":33,"phoneExt":33,"email":33},"John White, PharmD, PA-C",{"type":63,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Mary Paine","Professor",[73,76],{"name":74,"class":75},"Office of Dietary Supplements (ODS)","NIH",{"name":77,"class":75},"National Center for Complementary and Integrative Health (NCCIH)","100569416","early-phase-1-evaluating-the-pharmacokinetics-of-oregano-and-potential-oregano-drug-interactions-using-a-drug-cocktail-approach-100569416",false,"NCT06693960","Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach","Inclusion Criteria:\n\n* Between 18-64 years old and healthy\n* Not taking any medications (prescription and non-prescription) or dietary\u002Fherbal supplements that can interfere with study drug pharmacokinetics\n* Willing to abstain from consuming dietary\u002Fherbal supplements and citrus juices for several weeks\n* Willing to abstain from cannabis\u002Fmarijuana, hemp, and THC- and CBD-containing products for several weeks\n* Willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and the morning of the first day of each study arm\n* Willing to abstain from consuming any alcoholic beverages for at least 1 day prior to any study day and during the study day\n* Willing to use a secondary method of birth control that does not include the introduction or discontinuance of hormonal-based birth control (such as abstinence, copper IUD, or condoms). Specifically, regardless of the use hormonal-based birth control, a non-hormonal method should be used for the duration of the study and for three weeks following cessation of participation.\n* Willing to abstain from consuming oregano (as a food additive or otherwise) for the duration of the study\n* Geographically located within a 40-mile radius of Spokane and have the time to participate\n\nExclusion Criteria:\n\n* Under 18 or over 64 years old\n* Taking medications or dietary\u002Fherbal supplements that can interfere with study drug pharmacokinetics\n* Have a major illness\n* Taking medication\u002Fsupplements for a mineral deficiency\n* History of intolerance or allergy to oregano or any of the cocktail drugs (caffeine, dextromethorphan, losartan, midazolam, and omeprazole)\n* Use of cannabis\u002Fmarijuana, hemp, and CBD- and\u002For THC-containing products within the last month\n* Currently using drugs or illicit substances for recreational purposes\n* Pregnant or nursing\n* Geographically located outside the 40-mile radius of Spokane and do not have the time to participate\n* Cannot read and speak English",true,"ALL","18 Years","64 Years",{"count":89,"type":90},16,"ESTIMATED","INTERVENTIONAL",[93],"EARLY_PHASE1","The purpose of this clinical trial is to determine how the supplement oregano affects how the body metabolizes pharmaceutical drugs.",[96],"Interaction",[98,99,100,101,102,103],"pharmacokinetics","drug interaction","natural products","oregano","cytochrome P450","cocktail","2026-06-02",{"date":106,"type":107},"2026-06-04","ACTUAL",{"date":109,"type":107},"2024-09-26",{"date":111,"type":90},"2027-01-31",{"name":5,"class":6},1]