[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628330":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":50,"collaborators":20,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":20,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":20,"enrollmentInfo":62,"targetDuration":20,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":20,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"(ACTH)-dependent Cushing disease","EXPERIMENTAL","Patients with adrenocorticotropic hormone (ACTH)-dependent Cushing disease who may be considered candidates for surgical treatment",[13],"Drug: Fluoro-O-(2) fluoroethyl-L-tyrosine (FET) PET",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Fluoro-O-(2) fluoroethyl-L-tyrosine (FET) PET","Patients will receive intravenous administration of radiolabeled FET (5mCi ±10%) administered 20 minutes (±10minutes) prior to the initiation of the attenuation correction CT followed by the PET acquisition encompassing the participant's head\u002Fneck, centered on the pituitary gland.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Derek Johnson, MD","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Brent Gessner, MBA","CONTACT","507-284-2950","Gessner.Brent@mayo.edu",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-92.4699,44.02163,{"lat":44,"lon":43},[47,49],{"name":48,"role":28,"phone":29,"phoneExt":20,"email":20},"Brent Gessner",{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":24,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Derek R. Johnson","Principal Investigator","100628330","early-phase-1-fet-petct-imaging-to-localize-pituitary-adenomas-in-cushing-disease-100628330",false,"NCT07460232","FET PET\u002FCT Imaging To Localize Pituitary Adenomas In Cushing Disease","18Fluoro-O-(2) Fluoroethyl-L-tyrosine (FET) PET For Localization Of Pituitary Adenomas In Patients With Cushing Disease","Inclusion Criteria:\n\nPatients must meet ALL criteria listed below for entry:\n\n* Biochemically diagnosed ACTH-dependent Cushing disease.\n* No previous pituitary surgery.\n* Planned to undergo pituitary surgery for localization\u002Fresection of adenoma.\n* No contraindications for PET\u002FCT.\n* Recent (within 3 months) pituitary MR, or pending pituitary MR to be performed as close as possible to FET PET\u002FCT.\n* Age ≥ 18 years.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Pregnant as determined by a pregnancy test as per institutional guidelines for individuals of child-bearing potential\n* Declining to use effective contraceptive methods during the study (for individuals of child-bearing potential)\n* Need for emergent surgery that would be delayed by participation\n* Bacterial, viral, or fungal infections requiring systemic therapy\n* Serious co-morbidities and serious nonmalignant disease (e.g., hydronephrosis, kidney failure, liver failure, systemic or local inflammatory or autoimmune diseases or other conditions) that in the opinion of the investigator could compromise patient safety and\u002For protocol objectives\n* Known diagnosis of autoimmune disorders\n* Patients receiving any other investigational agent within the past 28 days\n* Breastfeeding. Note: nursing parents are allowed if the potential participant commits to pumping breast milk and discarding it from injection to ≥ 24 hours from the time of the FET injection.\n* Known hypersensitivity to any excipients used in FET","ALL","18 Years",{"count":63,"type":64},50,"ESTIMATED","INTERVENTIONAL",[67],"EARLY_PHASE1","The purpose of this research is to evaluate the performance \\[sensitivity, specificity, accuracy\\] of FET PET\u002FCT imaging to detect ACTH-secreting pituitary adenoma, using operative findings and histopathology as truth standard.",[70,71],"Cushing Disease","Pituitary Adenoma","2026-06-17",{"date":74,"type":75},"2026-06-22","ACTUAL",{"date":77,"type":75},"2026-04-27",{"date":79,"type":64},"2028-07",{"name":5,"class":6},1]