[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639843":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":21,"centralContacts":21,"locations":26,"responsibleParty":43,"collaborators":21,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":21,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":21,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":21,"overallStatus":65,"whyStopped":21,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},{"fullName":5,"class":6},"Genovn Therapeutics PTE. LTD.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"IL-15 Enhanced Engineered NK Cells","EXPERIMENTAL","Single arm. Patients receive IL-15 enhanced engineered NK cells after lymphodepletion chemotherapy.",[13,14],"Drug: IL-15 enhanced engineered NK cells","Biological: IL-15 Enhanced Engineered NK Cells",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","IL-15 enhanced engineered NK cells","Genetically engineered NK cells expressing IL-15. Administered intravenously. See protocol for dose details.",[9],null,{"type":23,"name":9,"description":24,"armGroupLabels":25,"otherNames":21},"BIOLOGICAL","Genetically engineered NK cells expressing IL-15",[9],[27],{"facility":28,"status":21,"city":29,"state":21,"zip":21,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Xinqiao Hospital","Chongqing","China","CN",{"type":33,"coordinates":34},"Point",[35,36],106.55771,29.56026,{"lat":36,"lon":35},[39],{"name":28,"role":40,"phone":41,"phoneExt":21,"email":42},"CONTACT","+86-23-68763468","jiaqingzhu0801@outlook.com",{"type":44,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100639843","early-phase-1-il-15-enhanced-nk-cell-therapy-for-solid-tumors-100639843",false,"NCT07621471","IL-15 Enhanced NK Cell Therapy for Solid Tumors","A Single-Arm Clinical Study of IL-15 Enhanced Engineered NK Cells for Refractory Relapsed\u002FMetastatic Solid Tumors","Inclusion Criteria:\n\n1. Age 18-70 years;\n2. ECOG 0-1;\n3. histopathologically confirmed metastatic or recurrent solid tumors (breast, liver, lung, etc.);\n4. failed prior standard therapy;\n5. \\>=1 measurable lesion per RECIST 1.1;\n6. adequate bone marrow, liver, kidney, and coagulation function;\n7. recovered from prior treatment toxicities;\n8. signed informed consent.\n\nExclusion Criteria:\n\n1. Pregnancy\u002Flactation;\n2. other malignancy within 5 years (except cured localized tumors);\n3. active autoimmune disease or immunodeficiency;\n4. uncontrolled cardiovascular disease or infection;\n5. active TB;\n6. positive HBsAg\u002FHBcAb or HCV antibody (unless viral load undetectable);\n7. positive syphilis antibody;\n8. major surgery or vaccination within 28 days;\n9. prior cell therapy;\n10. severe allergy to study drugs;\n11. investigator judged unsuitable.","ALL","18 Years","70 Years",{"count":56,"type":57},12,"ESTIMATED","INTERVENTIONAL",[60],"EARLY_PHASE1","A single-arm, Phase 1 study evaluating safety, tolerability, and preliminary efficacy of IL-15 enhanced engineered NK cells in patients with refractory relapsed or metastatic solid tumors.",[63,64],"Solid Tumors","Metastatic Cancer","NOT_YET_RECRUITING","2026-05-27",{"date":68,"type":69},"2026-06-02","ACTUAL",{"date":71,"type":57},"2026-07-01",{"date":73,"type":57},"2028-12-31",{"name":75,"class":6},"Genovn Therapeutics (Suzhou) Co., Ltd.",1]