[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548144":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":39,"locations":45,"responsibleParty":64,"collaborators":30,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":30,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":30,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":30,"overallStatus":47,"whyStopped":30,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8,16,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Hypoxia","EXPERIMENTAL","Participants will be exposed to hypoxia (low oxygen air) using a mask.",[13,14,15],"Drug: Placebo","Drug: Propranolol","Drug: Gemtesa",{"label":17,"type":10,"description":18,"interventionNames":19},"Cold pressor test","Participants will be exposed to the cold pressor test (ice water on the foot).",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Hypercapnia","Participants will be exposed to hypercapnia (high carbon dioxide air) using a mask.",[13,14,15],[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Placebo","Participants will receive a placebo in pill form.",[17,21,9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Propranolol","Participants will receive oral propranolol (1 mg\u002Fkg).",[17,21,9],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Gemtesa","Participants will receive oral gemtesa (75 mg).",[17,21,9],[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Jacqueline Limberg","CONTACT","573-882-2544","limberglab@missouri.edu",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Columbia","Missouri","65211","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-92.33407,38.95171,{"lat":57,"lon":56},[60],{"name":61,"role":42,"phone":62,"phoneExt":30,"email":63},"Jacqueline K Limberg, Ph.D.","573-882-2420","limbergj@missouri.edu",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Jacqueline K Limberg, PhD","Associate Professor","100548144","early-phase-1-impact-of-early-aging-and-menopause-on-the-vascular-responses-to-hypoxia-100548144",false,"NCT06417177","Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia","Inclusion Criteria:\n\n* Female assigned at birth\n* Pre, peri- or post-menopausal\n* Healthy weight (BMI ≥18 and ≤30 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Male (assigned at birth)\n* Pregnancy, breastfeeding\n* Use of hormone replacement therapies\n* Hysterectomy\n* Body mass index \\>30 kg\u002Fm2\n* Diagnosed sleep apnea\n* Current smoking\u002FNicotine\u002FDrug use\n* Nerve\u002Fneurologic disease\n* Cardiovascular, hepatic, renal, respiratory disease\n* Blood pressure ≥140\u002F90 mmHg\n* Diabetes, Polycystic ovarian syndrome\n* Communication barriers\n* Prescription medications\n* Malignant cancer",true,"FEMALE","18 Years","70 Years",{"count":79,"type":80},75,"ESTIMATED","INTERVENTIONAL",[83],"EARLY_PHASE1","The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.",[86,87,9,88],"Aging","Menopause","Vasodilation","2025-09-08",{"date":91,"type":92},"2025-09-09","ACTUAL",{"date":94,"type":92},"2024-06-03",{"date":96,"type":80},"2026-07",{"name":5,"class":6},1]