[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100466123":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":35,"responsibleParty":56,"collaborators":25,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":25,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":25,"overallStatus":79,"whyStopped":25,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Colorado, Denver","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy individuals - pre-iron","PLACEBO_COMPARATOR","Five healthy participants will be enrolled. Baseline echocardiography and exercise data prior to oral iron supplementation will be obtained as part of the \"parent\" study to this study (NCT05272514).",[13],"Drug: Ferrous sulfate 325mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Healthy individuals - post-iron","ACTIVE_COMPARATOR","The same five healthy participants will complete echocardiography and exercise testing after taking 30 days of oral iron supplementation.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Ferrous sulfate 325mg","Participants will take one tab of ferrous sulfate 325 mg (equivalent to 65 mg elemental iron) daily for 30 days.",[15,9],null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"William Cornwell, MD","CONTACT","303-724-2085","william.cornwell@cuanschutz.edu",{"name":33,"role":29,"phone":25,"phoneExt":25,"email":34},"Lindsay Forbes, MD","lindsay.forbes@cuanschutz.edu",[36],{"facility":37,"status":25,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"University of Colorado Anschutz Medical Campus","Aurora","Colorado","80045","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-104.83192,39.72943,{"lat":47,"lon":46},[50,51,52,54],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},{"name":33,"role":29,"phone":25,"phoneExt":25,"email":34},{"name":28,"role":53,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"name":33,"role":55,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"type":57,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100466123","early-phase-1-impact-of-iron-supplementation-on-right-ventricular-function-and-exercise-performance-in-hypoxia-100466123",false,"NCT05349630","Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia","Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia (A Sub-Study)","Inclusion Criteria:\n\n* Age 18 - 60\n* For women, premenopausal status\n\nExclusion Criteria:\n\n* Active cardiovascular or pulmonary disease (e.g. hypertension, coronary artery disease, cardiomyopathy, arrhythmia, valvular abnormalities, diabetes, peripheral vascular disease, tobacco use, chronic obstructive pulmonary disease, asthma, interstitial lung disease, restrictive lung disease, or pulmonary hypertension)\n* Use of cardiac- or pulmonary-related medications\n* Prior history of high altitude pulmonary edema or high altitude cerebral edema\n* Body mass index \\\u003C 18.5 or \\> 30\n* Anemia\n* Iron deficiency\n* Iron supplementation (oral or intravenous) in the preceding 60 days\n* Systemic anticoagulation or aspirin use that cannot be temporarily held for the study\n* Pregnancy\n* Non-cardiopulmonary disorders that adversely influence exercise ability (e.g. arthritis or peripheral vascular disease)\n* Dedicated athletic training (defined here as spending \\>9 hours per week in vigorous physical activity \\[≥6 mets\\])\n* Regular high-altitude exercise (defined here as engaging in vigorous physical activity \\[≥1 hour at ≥6 mets\\] at ≥8,000 ft for \\>2 days per week over the preceding 4 weeks)\n* Residence at ≥8,000 ft for 3 or more consecutive nights in the preceding 30 days",true,"ALL","18 Years","60 Years",{"count":70,"type":71},5,"ESTIMATED","INTERVENTIONAL",[74],"EARLY_PHASE1","The purpose of this study is to determine if taking iron supplement pills improves exercise performance in low-oxygen conditions.",[77,78],"Right Ventricular Dysfunction","Hypoxia","NOT_YET_RECRUITING","2026-04-27",{"date":82,"type":83},"2026-04-29","ACTUAL",{"date":85,"type":71},"2028-03",{"date":87,"type":71},"2030-05",{"name":5,"class":6},1]