[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637649":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":31,"responsibleParty":48,"collaborators":20,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":20,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":20,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":34,"whyStopped":20,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Northwell Health","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Active rTMS Arm","EXPERIMENTAL","We will investigate how repetitive transcranial magnetic stimulation (rTMS) affects brain networks in patients with dystonia by measuring changes in resting state-functional magnetic resonance images (rs-fMRI).",[13],"Device: Transcranial Magnetic Stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Transcranial Magnetic Stimulation","Continuous theta-burst stimulation (cTBS), a modified form of rTMS that mimics natural brain rhythms (theta 4-8Hz), can effectively inhibit the cortical hyperactivity in targeted hubs with shorter treatment times than traditional approaches. The rationale for this proposed pilot experiment is to combine advanced analysis of standard neuroimaging to refine target location for a test of whether the application of non-invasive rTMS (in the form of cTBS) modulates abnormal cortical regions or the entire brain network, or both, as these networks underlie dystonia. This pilot study will provide the basis for a controlled study to test the effectiveness and robustness of any positive influence that TMS might have on the patients' dystonia.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Celina B Fernandez, MS","CONTACT","516-562-3646","cfernandez14@northwell.edu",{"name":28,"role":24,"phone":29,"phoneExt":20,"email":30},"Bruce T Volpe, MD","516-562-3384","bvolpe1@northwell.edu",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Northwell Health\u002FFeinstein Institutes","RECRUITING","Manhasset","New York","11030","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-73.69957,40.79788,{"lat":44,"lon":43},[47],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Bruce Volpe","Professor, Investigator","100637649","early-phase-1-impact-of-rtms-on-abnormal-cortical-fmri-in-patients-with-dystonia-100637649",false,"NCT07626216","Impact of rTMS on Abnormal Cortical fMRI in Patients With Dystonia","The Effect of Repetitive Trans-cranial Magnetic (rTMS) Stimulation on Abnormal Cortical Hubs Identified by Functional Magnetic Resonance in Subjects With Dystonia.","Inclusion Criteria:\n\n* Male or female\n* 18 and 80 years of age.\n* Patients who manifest dystonia - sustained involuntary movement of the head, neck, trunk or limbs.\n* The dystonia may be spontaneous or genetic, specifically DYT1 or DYT6 and then only those patients who are demonstrating dystonia. The patient\u002Fsubject will have a normal neurological exam except for dystonia.\n\nExclusion Criteria:\n\n* Heredodegenrative dystonia of the type DYT8,9 or 10.\n* Past history of head trauma, stroke, epilepsy, demyelinating disease\n* Hypertension in excess of 160mmHg systolic and 90mmHg diastolic\n* Congestive heart failure\n* Diabetes\n* Past psychiatric conditions: e.g., depression\n* Systemic metabolic disease: e.g., Wilson's disease, progressive neurodegenerative disease (like supranuclear palsy or corticobasal ganglionic degeneration)\n* Magnetizable incorporated metal parts - like pacemakers\n* History or diagnosis of Parkinson's disease\n* Presence of myoclonus\n* No previous surgery for dystonia\n* Long term exposure to benzodiazepines, neuroleptics or anticonvulsants\n* No botulinum toxin within 12 weeks of baseline assessment and fMRI.\n* Moderate to severe cognitive impairment (judged by a minimental status of \\\u003C24.)","ALL","18 Years","80 Years",{"count":63,"type":64},10,"ESTIMATED","INTERVENTIONAL",[67],"EARLY_PHASE1","By tracking resting-state fMRI scans, we aim to discover how repetitive transcranial magnetic stimulation (rTMS) changes brain connectivity in individuals with dystonia.",[70],"Dystonia Disorder",[72],"Transcranial Magnetic Stimulation, Heperkinetic Movement Disorder,Truncal (Axial) Dystonia, Abnormal Posture,Contractions of the chest, back,abdominal muscles","2026-05-29",{"date":75,"type":76},"2026-06-04","ACTUAL",{"date":78,"type":76},"2026-03-04",{"date":80,"type":64},"2029-05",{"name":5,"class":6},1]