[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584800":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":40,"collaborators":26,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":26,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":26,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":69,"whyStopped":26,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":26},{"fullName":5,"class":6},"University of Jordan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"DXM","EXPERIMENTAL","Patients in this group will receive a standard root canal treatment but with the extra step of extruding a Dexamethasone (DXM) solution through the root canals to the periradicular tissues prior to obturation.",[13],"Drug: Dexamethasone",{"label":15,"type":16,"description":17,"interventionNames":18},"Saline","PLACEBO_COMPARATOR","Patients in this group will receive a standard root canal treatment with saline used as the final irrigating solution prior to obturation.",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Dexamethasone","a 2 ml solution of dexamethasone (3.3mg\u002Fml) will be flushed in the root canal and intentionally extruded to the periradicular tissues to assess its potnetial sedative effect",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","2ml of normal saline will be used as placebo to be flushed and extruded through the canals to the periradicular tissues",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Renad H Khanfer","CONTACT","+962795101571","renad_hazem@hotmai.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":26},"Ahmad M El Ma'aita","+962799552225",{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Renad Hazem Khanfer","Doctor","100584800","early-phase-1-intracanal-dexamethasone-extrusion-and-postoperative-endodontic-pain-100584800",false,"NCT06894069","Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain","Effect of Intentional Extrusion of an Intracanal Corticosteroid Solution on Post Endodontic Treatment Pain: a Randomized Clinical Trial","Inclusion Criteria:\n\n* A diagnosis of irreversible pulpits with symptomatic apical periodontitis\n* Adult patients (aged 18 - 70)\n* Healthy patients or those with a well-controlled disease (ASA I \\& II)\n\nExclusion Criteria:\n\n* A diagnosis of necrotic pulp, or normal apical tissues\n* Patients with a severe systemic disease (ASA III or higher)\n* Patients who received analgesics12 hours before presentation\n* Previously treated\u002Finitiated Endodontics treatment on the same tooth\n* Unopposed teeth\n* Third molar teeth\n* Non-restorable teeth\n* Periodontally compromised teeth\n* Pregnant or lactating patients","ALL","18 Years","70 Years",{"count":55,"type":56},80,"ESTIMATED","INTERVENTIONAL",[59],"EARLY_PHASE1","The aim of this research is to assess the effect of intentionally extruding a corticosteroid intracanal solution into the periapical tissues on the postoperative pain after root canal treatment in patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis (SIP\u002FSAP). The main question it aims to answer: Is there an analgesic effect of extruding an intracanal solution of DXA into the periapical tissues in patients diagnosed with SIP\u002FSAP? Researchers will compare dexamethasone to a placebo to see if the extrusion dexamethasone works in reducing post-endodontic treatment pain.",[62,63],"Post Operative Pain Control","Endodontic Treatment",[65,66,67,23,68],"Root canal treatment","Post-operative pain","Corticosteroids","Randomised controlled trial","NOT_YET_RECRUITING","2025-03-25",{"date":72,"type":73},"2025-03-26","ACTUAL",{"date":75,"type":56},"2025-03",{"date":77,"type":56},"2025-05",{"name":5,"class":6}]