[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615552":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":40,"centralContacts":44,"locations":50,"responsibleParty":66,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":48,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":52,"whyStopped":48,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Propofol, followed by propofol+ketamine (given at first visit)","EXPERIMENTAL","* Propofol, followed by propofol+ketamine at Visit 1\n* Ketamine, followed by ketamine+propofol at Visit 3\n* Propofol, followed by propofol+ketamine at Visit 5\n* Ketamine, followed by ketamine+propofol at Visit 7\n\nEEG will be done at either visits 1 and 3 or 5 and 7; fMRI will be done at the other two (non-EEG) visits.",[13,14,15],"Drug: Propofol","Drug: Ketamine","Device: Peripheral Nerve Stimulation",{"label":17,"type":10,"description":18,"interventionNames":19},"Ketamine, followed by ketamine+propofol (given at first visit)","* Ketamine, followed by ketamine+propofol at Visit 1\n* Propofol, followed by propofol+ketamine at Visit 3\n* Ketamine, followed by ketamine+propofol at Visit 5\n* Propofol, followed by propofol+ketamine at Visit 7\n\nEEG will be done at either visits 1 and 3 or 5 and 7; fMRI will be done at the other two (non-EEG) visits.",[13,14,15],[21,28,33],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Propofol","Subjects will receive an intravenous infusion of this drug, during portions of the study.",[17,9],[27],"Diprivan",{"type":22,"name":29,"description":24,"armGroupLabels":30,"otherNames":31},"Ketamine",[17,9],[32],"ketalar",{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"DEVICE","Peripheral Nerve Stimulation","Experimental acute pain stimulus will be delivered using a nerve stimulator. These painful shocks will be paired with specific experimental events.",[17,9],[39],"electric nerve stimulation",[41],{"name":42,"affiliation":5,"role":43},"Keith M Vogt, MD, PhD","PRINCIPAL_INVESTIGATOR",[45],{"name":42,"role":46,"phone":47,"phoneExt":48,"email":49},"CONTACT","4126473147",null,"kev18@pitt.edu",[51],{"facility":5,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"RECRUITING","Pittsburgh","Pennsylvania","15213","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-79.99589,40.44062,{"lat":62,"lon":61},[65],{"name":42,"role":46,"phone":47,"phoneExt":48,"email":49},{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":48,"oldOrganization":48},"SPONSOR_INVESTIGATOR","Keith M Vogt","Associate Professor",[71],{"name":72,"class":73},"National Institute of General Medical Sciences (NIGMS)","NIH","100615552","early-phase-1-ketamine-and-propofol-neuroimaging-100615552",false,"NCT07294092","Ketamine and Propofol NeuroImaging","KAPNI","Inclusion Criteria:\n\n* Adults 18-59 years of age, who:\n* have none of the specific exclusion criteria\n* have a valid email address and valid phone number throughout the study\n* free from any non-MRI compatible implants\n\nExclusion Criteria:\n\n* are pregnant or attempting to conceive\n* body mass index (BMI) \\> 35\n* significant memory impairment or hearing loss\n* sleep apnea\n* chronic pain or frequently taking pain medication\n* chronic medical conditions requiring treatment (hypertension, diabetes, high cholesterol)\n* neurologic disease, including seizures and tremor\n* psychiatric diagnoses, including anxiety, depression, panic, or PTSD\n* a history of any of these medical conditions: abnormal heartbeats (cardiac conduction abnormality or arrhythmia), liver or kidney disease, or significant lung disease\n* severe claustrophobia or intolerance of an MRI\n* have metal implants or non-removable metal piercings\n* having a history of adverse reaction to ketamine or propofol\n* daily alcohol or heavy alcohol use; history of alcohol abuse\n* current daily smoker\n* regular or recent marijuana use (including prescribed\u002Fmedical marijuana)\n* illicit drug use, i.e., street drugs\n* regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids",true,"ALL","18 Years","59 Years",{"count":86,"type":87},60,"ESTIMATED","INTERVENTIONAL",[90],"EARLY_PHASE1","This is a multi-visit which will collect MRI (pictures of the brain) and EEG (brain waves) data to determine changes in brain connectivity and brain activity for memory formation and pain perception while receiving the commonly-used anesthetic agents ketamine and propofol, both alone and in combination.",[93,94],"Anesthesia","Pain",[23,29,96,39,97,98],"functional MRI","sedation","functional connectivity","2026-05-15",{"date":101,"type":102},"2026-05-19","ACTUAL",{"date":104,"type":102},"2026-04-10",{"date":106,"type":87},"2028-08-02",{"name":68,"class":6},1]