[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100412319":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":36,"centralContacts":40,"locations":46,"responsibleParty":65,"collaborators":67,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":44,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":44,"enrollmentInfo":80,"targetDuration":44,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":44,"overallStatus":48,"whyStopped":44,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Epilepsy patient volunteers","EXPERIMENTAL","Patients recruited for the study with intractable epilepsy who are anticipated to undergo epilepsy surgery",[13,14,15],"Diagnostic Test: 3T Magnetic Resonance Imaging","Diagnostic Test: Intracranial electroencephalography recordings","Diagnostic Test: 7T Magnetic Resonance Imaging",[17,24,30],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DIAGNOSTIC_TEST","3T Magnetic Resonance Imaging","Magnetic resonance imaging acquired at a field strength of 3 Tesla.",[9],[23],"3T MRI",{"type":18,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Intracranial electroencephalography recordings","Epilepsy patients may undergo implantation of intracranial electroencephalography (iEEG) electrodes for localization of epileptogenic foci, which also provide a means to record localized brain activity during memory or other tasks for research purposes.",[9],[29],"Intracranial EEG recordings",{"type":18,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"7T Magnetic Resonance Imaging","Magnetic resonance imaging acquired at a field strength of 7 Tesla.",[9],[35],"7T MRI",[37],{"name":38,"affiliation":5,"role":39},"Kathryn A Davis, MD, MSTR","PRINCIPAL_INVESTIGATOR",[41],{"name":38,"role":42,"phone":43,"phoneExt":44,"email":45},"CONTACT","215-349-5166",null,"katedavis@pennmedicine.upenn.edu",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-75.16362,39.95238,{"lat":58,"lon":57},[61],{"name":62,"role":42,"phone":63,"phoneExt":44,"email":64},"Carolyn Wilkinson, BSN","215-746-4850","wilkinsc@seas.upenn.edu",{"type":66,"investigatorFullName":44,"investigatorTitle":44,"investigatorAffiliation":44,"oldNameTitle":44,"oldOrganization":44},"SPONSOR",[68],{"name":69,"class":6},"Medical University of South Carolina","100412319","early-phase-1-localizing-epileptic-networks-using-mri-and-ieeg-100412319",false,"NCT04649008","Localizing Epileptic Networks Using MRI and iEEG","Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics","Inclusion Criteria:\n\n* Patients with medication-refractory epilepsy\n* Planned intracranial EEG (IEEG) placement\n* Hypothesized to have temporal lobe epilepsy\n\nExclusion Criteria:\n\n* Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)",true,"ALL","18 Years",{"count":81,"type":82},290,"ESTIMATED","INTERVENTIONAL",[85],"EARLY_PHASE1","Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.",[88,89,90],"Epilepsy","Epilepsy Intractable","Epilepsy, Temporal Lobe","2026-02-11",{"date":93,"type":94},"2026-02-13","ACTUAL",{"date":96,"type":94},"2021-03-01",{"date":98,"type":82},"2027-02-28",{"name":5,"class":6},1]