[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628434":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":11,"centralContacts":49,"locations":11,"responsibleParty":55,"collaborators":11,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":11,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":11,"enrollmentInfo":67,"targetDuration":11,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":11,"overallStatus":78,"whyStopped":11,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":11},{"fullName":5,"class":6},"Boston University Charles River Campus","OTHER",[8,14,18,22,26,30],{"label":9,"type":10,"description":11,"interventionNames":12},"1-day patterned tACS","EXPERIMENTAL",null,[13],"Device: 1-day patterned tACS",{"label":15,"type":10,"description":11,"interventionNames":16},"3-day patterned tACS",[17],"Device: 3-day patterned tACS",{"label":19,"type":10,"description":11,"interventionNames":20},"5-day patterned tACS",[21],"Device: 5-day patterned tACS",{"label":23,"type":10,"description":11,"interventionNames":24},"1-day continuous tACS",[25],"Device: 1-day continuous tACS",{"label":27,"type":10,"description":11,"interventionNames":28},"3-day continuous tACS",[29],"Device: 3-day continuous tACS",{"label":31,"type":10,"description":11,"interventionNames":32},"5-day continuous tACS",[33],"Device: 5-day continuous tACS",[35,39,41,43,45,47],{"type":36,"name":9,"description":37,"armGroupLabels":38,"otherNames":11},"DEVICE","Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp with the goal of modulating levels of neuronal excitability.",[9],{"type":36,"name":15,"description":37,"armGroupLabels":40,"otherNames":11},[15],{"type":36,"name":19,"description":37,"armGroupLabels":42,"otherNames":11},[19],{"type":36,"name":23,"description":37,"armGroupLabels":44,"otherNames":11},[23],{"type":36,"name":27,"description":37,"armGroupLabels":46,"otherNames":11},[27],{"type":36,"name":31,"description":37,"armGroupLabels":48,"otherNames":11},[31],[50],{"name":51,"role":52,"phone":53,"phoneExt":11,"email":54},"Robert Reinhart, PhD","CONTACT","(617) 353-9481","rmgr@bu.edu",{"type":56,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100628434","early-phase-1-memory-enhancement-in-aging-with-optimal-dosing-100628434",false,"NCT07461584","Memory Enhancement in Aging With Optimal Dosing","Personalized Memory Enhancement in Aging: Pattern-Optimized tACS With Closed-Loop Precision Modulation","Inclusion Criteria:\n\n* 65 years of age or older\n* normal or corrected-to-normal vision\n* color vision\n\nExclusion Criteria:\n\n* pregnant\n* metal implants in head\n* implanted electronic devices\n* history of neurological problems or head injury\n* skin sensitivity\n* claustrophobia\n* dementia (normal Montreal Cognitive Assessment \\> 25)\n* depression (normal Geriatric Depression Scale \\\u003C 10)\n* history of psychosis\n* cognitive deficits (MoCA\\>25)\n* any psychoactive medication",true,"ALL","65 Years",{"count":68,"type":69},240,"ESTIMATED","INTERVENTIONAL",[72],"EARLY_PHASE1","This project optimizes high-resolution tACS to improve memory in healthy older adults, advancing drug-free approaches for ADRD. We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen memory-supporting networks.",[75,76,77],"Aging","Noninvasive Brain Stimulation","Memory","NOT_YET_RECRUITING","2026-04-01",{"date":81,"type":82},"2026-04-07","ACTUAL",{"date":84,"type":69},"2026-05-01",{"date":86,"type":69},"2031-01-31",{"name":5,"class":6}]