[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592167":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":49,"collaborators":52,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":20,"enrollmentInfo":69,"targetDuration":20,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Medical University of South Carolina","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Operant Up-Conditioning of the Motor Evoked Potential","EXPERIMENTAL","The intervention consists of approximately 6 baseline sessions and 24 conditioning sessions at a pace of 3 sessions\u002Fweek, 1-2 hour duration, over 10 weeks. At the beginning of each session, electromyographic (EMG) recording and nerve stimulating electrodes are placed over the arm. In all sessions, motor evoked potentials (MEPs) will be measured while the sitting subject provides a pre-set level of background muscle EMG with joint angles fixed. In 225 control trials of each baseline sessions and the first 20 trials of conditioning sessions the subject will receive no feedback as to MEP size (i.e., control MEPs). In 225 conditioning trials of each conditioning session, the subject will be encouraged to increase the target muscle MEP, and will receive immediate feedback as to whether MEP size was above a criterion (i.e., whether the trial was a success).",[13],"Behavioral: Up-conditioning of the wrist extensor motor evoked potential",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Up-conditioning of the wrist extensor motor evoked potential","At the beginning of each session, EMG recording and nerve stimulating electrodes are placed over the arm. In all sessions, MEPs will be measured while the sitting subject provides a pre-set level of background muscle EMG with joint angles fixed. In 225 control trials of each baseline sessions and the first 20 trials of conditioning sessions the subject will receive no feedback as to MEP size (i.e., control MEPs). In 225 conditioning trials of each conditioning session, the subject will be encouraged to increase the target muscle MEP, and will receive immediate feedback as to whether MEP size was above a criterion (i.e., whether the trial was a success).",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Allison Lewis, DPT, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Recruitment Contact","CONTACT","843-792-6313","stecb@musc.edu",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Charleston","South Carolina","29425","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-79.93275,32.77632,{"lat":43,"lon":42},[46,48],{"name":23,"role":28,"phone":29,"phoneExt":20,"email":47},"lewisaf@musc.edu",{"name":23,"role":24,"phone":20,"phoneExt":20,"email":20},{"type":24,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Allison Lewis","Post-doctoral Scholar, Principal Investigator",[53,56],{"name":54,"class":55},"Doscher Neurorehabilitation Research Program","UNKNOWN",{"name":57,"class":58},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH","100592167","early-phase-1-mep-up-conditioning-to-target-corticospinal-plasticity-100592167",false,"NCT06989905","MEP Up-conditioning to Target Corticospinal Plasticity","Operant Conditioning of the Wrist Extensor Motor Evoked Potential to Target Corticospinal Plasticity and Upper Limb Motor Recovery After Cervical Spinal Cord Injury","uMEP2","Inclusion Criteria:\n\n* Adult (≥18 yrs old)\n* A history of injury to spinal cord at or above C6\n* \\>6 months post SCI\n* Weak wrist extension at least unilaterally\n* Expectation that current medication will be maintained without change for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted.\n\nExclusion Criteria:\n\n* Motoneuron injury\n* Medically unstable condition\n* Cognitive impairment\n* A history of epileptic seizures\n* Metal implants in the cranium\n* Implanted biomedical device in or above the chest (e.g., a cardiac pacemaker, cochlear implant)\n* Extensive use of functional electrical stimulation to the arm on a daily basis\n* Pregnancy (due to changes in posture and potential medical instability)\n* Contraindications to MRI\n* No measurable MEP elicited in the ECR\n* Unable to produce any voluntary ECR EMG activity","ALL","18 Years",{"count":70,"type":71},11,"ESTIMATED","INTERVENTIONAL",[74],"EARLY_PHASE1","Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor).\n\nInvestigators will assess the impact of the brain stimulation training on 1) the brain-to-spinal cord-to-muscle connection and 2) motor functions of the arm and hand. Also, brain and spine magnetic resonance imaging will be collected before and after the training. The imaging measurements will tell investigators about how spinal damage, brain function, and brain structure relate to motor presentation and the response to the training.",[77,78],"Spinal Cord Injury","Tetraplegia\u002FTetraparesis",[80,81,82,83,84,85,86,87,88,89],"Central Nervous System","Nervous System","Rehabilitation Studies","Spinal Cord","spinal cord injury","upper extremity","upper limb","motor impairment","tetraplegia","quadriplegia","2026-03-25",{"date":92,"type":93},"2026-03-30","ACTUAL",{"date":95,"type":93},"2025-05-27",{"date":97,"type":71},"2027-03-31",{"name":5,"class":6},1]