[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100467652":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":82,"collaborators":24,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":24,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":24,"overallStatus":46,"whyStopped":24,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"University of Monastir","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mini Bolus 50","ACTIVE_COMPARATOR","receiving a \"mini-bolus A\":50 ml of crystalloid solution, regularly infused over 30 seconds",[13],"Diagnostic Test: passive leg rising test",{"label":15,"type":6,"description":16,"interventionNames":17},"PLR","Passive leg raising technique: Initially, the patient is placed semi-recumbent with the head of the bed at 45°. After recording baseline measurement, the head of the bed is lowered and the legs are elevated to 45° for 2 minutes",[18],"Combination Product: Mini bolus 50",[20,25],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":24},"COMBINATION_PRODUCT","Mini bolus 50",[15],null,{"type":26,"name":27,"description":16,"armGroupLabels":28,"otherNames":24},"DIAGNOSTIC_TEST","passive leg rising test",[9],[30],{"name":31,"affiliation":32,"role":33},"Semir Nouira, Prof","University Hospital Fattouma Bourguiba Monastir , Emergency Department .","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":24,"email":38},"CONTACT","+21673106046","semir.nouira.urg@gmail.com",{"name":40,"role":36,"phone":41,"phoneExt":24,"email":42},"Khaoula Bel Haj Ali, MD","99792724","belhajalikhaoula@yahoo.fr",[44,71],{"facility":45,"status":46,"city":47,"state":24,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Emergency Departement","RECRUITING","Monastir","5000","Tunisia","TN",{"type":52,"coordinates":53},"Point",[54,55],10.82617,35.77799,{"lat":55,"lon":54},[58,63,67,69],{"name":59,"role":36,"phone":60,"phoneExt":61,"email":62},"Semir Nouira, professor","73 106 085","216","semir.nouira@rns.tn",{"name":64,"role":36,"phone":65,"phoneExt":61,"email":66},"kouraichi cyrine, MD","55598213","cyrinekouraichi@hotmail.com",{"name":68,"role":33,"phone":24,"phoneExt":24,"email":24},"semir nouira, professor",{"name":40,"role":70,"phone":24,"phoneExt":24,"email":24},"SUB_INVESTIGATOR",{"facility":72,"status":46,"city":47,"state":24,"zip":24,"country":49,"countryCode":50,"cosmosGeoPoint":73,"geoPoint":75,"contacts":76},"Emergency department",{"type":52,"coordinates":74},[54,55],{"lat":55,"lon":54},[77,79],{"name":78,"role":36,"phone":37,"phoneExt":24,"email":62},"Semir Nouira, head chief",{"name":80,"role":36,"phone":81,"phoneExt":24,"email":38},"Semir Nouira","+21673106000",{"type":33,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Pr. Semir Nouira","Head chief, Emmergency Department ,University Hospital of Monastir","100467652","early-phase-1-mini-bolus-for-fluid-challenge-responsiveness-in-the-emergency-department-100467652",false,"NCT05369559","Mini Bolus for Fluid Challenge Responsiveness in the Emergency Department","MIBORED","Inclusion Criteria:\n\n* Patients with spontaneous breathing\n* Patients in whom a fluid challenge is indicated because they present acute circulatory failure (which is defined as systolic blood pressure less than 90 mmHg or the need for vasopressors (norepinephrine more than 0.1 µg\u002Fkg\u002Fmin) to maintain a systolic blood pressure more than 90 mmHg (14), and at least one sign of inadequate tissue perfusion:\n\n  * urine output of below 0.5ml\u002Fkg per hour over 1 hour\n  * tachycardia (heart rate of greater than 100 beats per minute)\n  * mottled skin.\n  * lactate \\> 2 mmol\u002Fl\n\nExclusion Criteria:\n\n* Cardiac arrest\n* Acute respiratory distress syndrome\n* Coma Glasgow Scale \\\u003C 14\n* Age of less than 18 years\n* Moribund patients\n* Pregnant patients\n* impossibility to perform passive leg raising (PLR) (trauma patients, lower extremity amputees, and prone patients)\n* Patients with cardiac arrhythmias\n* Patients with cardiogenic pulmonary oedema","ALL","18 Years","80 Years",{"count":96,"type":97},1000,"ESTIMATED","INTERVENTIONAL",[100],"EARLY_PHASE1","Intravascular volume expansion is a common intervention in critically ill patients with acute circulatory failure.we test the hypothesis that a mini-bolus fluid challenge, of either 50 ml , can predict fluid responsiveness in spontaneously breathing patients with hemodynamic instability.",[103],"Fluid Therapy","2024-07-04",{"date":106,"type":107},"2024-07-09","ACTUAL",{"date":109,"type":107},"2022-03-03",{"date":111,"type":97},"2025-05-22",{"name":5,"class":6},2]