[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100406426":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":63,"collaborators":67,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":30,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":43,"whyStopped":30,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Montelukast","EXPERIMENTAL","Patients will receive oral montelukast (10 mg) daily for 6 months after surgery.",[13],"Drug: Montelukast",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Patients will receive an oral placebo daily for 6 months after surgery.",[19],"Drug: Placebo",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","The novel use of oral montelukast offers the potential of a disease modifying treatment to prevent irreversible cartilage loss after ACL injury. 10mg of oral Montelukast will be taken daily for 6 months post surgery.",[9],[26],"Singulair",{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"An oral placebo will be taken daily for 6 months post surgery.",[15],null,[32],{"name":33,"affiliation":5,"role":34},"Austin Stone, MD, PhD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":30,"email":39},"CONTACT","859.218.3065","austin.stone@uky.edu",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"UK Healthcare at Turfland","RECRUITING","Lexington","Kentucky","40504","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-84.47772,37.98869,{"lat":53,"lon":52},[56,58,61],{"name":33,"role":37,"phone":57,"phoneExt":30,"email":39},"859-218-3065",{"name":59,"role":60,"phone":30,"phoneExt":30,"email":30},"Cale Jacobs, PhD","SUB_INVESTIGATOR",{"name":62,"role":34,"phone":30,"phoneExt":30,"email":30},"Austin Stone, MD",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"SPONSOR_INVESTIGATOR","Austin V Stone","Director of Research Orthopedic Surgery",[68,70,72],{"name":69,"class":6},"Duke University",{"name":71,"class":6},"The Cleveland Clinic",{"name":73,"class":6},"University of California, San Francisco","100406426","early-phase-1-montelukast-as-a-potential-chondroprotective-treatment-following-anterior-cruciate-ligament-reconstruction-mocha-trial-100406426",false,"NCT04572256","MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)","MOCHA","Inclusion Criteria:\n\n1. Undergoing primary ACL reconstruction\n2. Age between 25-50\n3. Concomitant meniscus injury\n\nExclusion Criteria:\n\n1. Undergoing revision procedures\n2. Multiple ligament injuries requiring multiple ligament reconstruction\u002Frepair\n3. Depressive symptoms and\u002For those who endorse suicidal ideation at the time of enrollment (PHQ-9 score \\>= 15)\n4. Found to not have a meniscus tear at the time of surgery","ALL","25 Years","50 Years",{"count":85,"type":86},30,"ESTIMATED","INTERVENTIONAL",[89],"EARLY_PHASE1","This is a multicenter randomized, placebo-controlled trial to assess whether a 6-month course of oral montelukast after ACL reconstruction reduces systemic markers of inflammation and biochemical and imaging biomarkers of cartilage degradation. This study will specifically target older ACL reconstruction patients with concomitant meniscal injuries as this group is at greatest risk of rapid PTOA progression. Patients will randomly be assigned to receive oral montelukast (10 mg) versus placebo daily for 6 months after surgery.",[92,93,94],"ACL Injury","Meniscus Tear","Post-traumatic Osteoarthritis",[96,97],"knee ligament","osteoarthritis","2026-06-08",{"date":100,"type":101},"2026-06-10","ACTUAL",{"date":103,"type":101},"2021-02-01",{"date":105,"type":86},"2027-06",{"name":65,"class":6},1]