[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100347967":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":23,"locations":31,"responsibleParty":48,"collaborators":18,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":18,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":18,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":18,"overallStatus":33,"whyStopped":18,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Children's Hospital of Philadelphia","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Renal tumors","Any patient with Wilms tumor or clear cell sarcoma of the kidney who would require radiation therapy as standard of care. Patients may receive an investigation drug for Wilms or CCSK given concurrently or within the first four weeks of the first fraction of proton therapy administration.",[12],"Other: Proton beam radiation using pencil beam scanning",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":18},"Proton beam radiation using pencil beam scanning","Proton beam radiation using pencil beam scanning, characterized by Bragg peak dose deposition and high conformality of dose to target regions",[9],null,[20],{"name":21,"affiliation":5,"role":22},"Christine Hill-Kayser, MD","PRINCIPAL_INVESTIGATOR",[24,28],{"name":21,"role":25,"phone":26,"phoneExt":18,"email":27},"CONTACT","215-590-2810","hill@uphs.upenn.edu",{"name":29,"role":25,"phone":18,"phoneExt":18,"email":30},"Ratnakar Patti","PATTIR@chop.edu",[32],{"facility":5,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Philadelphia","Pennsylvania","19104","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-75.16362,39.95238,{"lat":43,"lon":42},[46,47],{"name":21,"role":25,"phone":26,"phoneExt":18,"email":27},{"name":29,"role":25,"phone":18,"phoneExt":18,"email":30},{"type":49,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100347967","early-phase-1-pencil-beam-scanning-in-patients-with-renal-tumors-100347967",false,"NCT03810651","Pencil Beam Scanning in Patients With Renal Tumors","Pilot Study of Pencil Beam Scanning Proton Beam Radiation Therapy in Patients With Renal Tumors","Inclusion Criteria:\n\n* Less than 30 years of age\n* Diagnosis\n\n  a. Any patient with Wilms tumor or clear cell sarcoma of the kidney who would require radiation therapy as standard of care including\n  1. Any patient with favorable histology (FH), stage III disease\n  2. Any patient with focal or diffuse anaplasia\n  3. Any patient with CCSK\n* The patient is a candidate for external beam radiotherapy based on standard of care for treatment of Wilms tumor or CCSK\n\nExclusion Criteria:\n\n* Prior radiotherapy to the region of the study cancer\n* Chemotherapy administered for diagnosis of Wilms tumor or CCSK\n* Pregnant or breastfeeding","ALL","0 Years","30 Years",{"count":61,"type":62},28,"ESTIMATED","INTERVENTIONAL",[65],"EARLY_PHASE1","This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.",[68,69],"Renal Tumor","Wilms Tumor","2026-04-13",{"date":72,"type":73},"2026-04-15","ACTUAL",{"date":75,"type":73},"2017-12-26",{"date":77,"type":62},"2028-10-30",{"name":5,"class":6},1]