[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100484896":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":57,"collaborators":60,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":25,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":88,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Scopolamine (0.4mg)","EXPERIMENTAL","Subjects will receive a dose of scopolamine (0.4mg) on each day. Approximately 15 minutes after administration, the participant will then complete either an episodic or a spatial memory task session.\n\nIf the patient completed the sham session already, this session will take place the day following the initial session, or at least four half-lives after the first session.",[13],"Drug: Scopolamine (0.4mg)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Subjects will receive saline (0.4mg) via IV on each day. Approximately 15 minutes after administration, the participant will then complete either an episodic or a spatial memory task session.\n\nIf the patient completed the scopolamine session already, this session will take place the day following the initial session, or at least four half-lives after the first session.",[19],"Drug: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Patient receives a dose of scopolamine (0.4mg) via IV fifteen minutes prior to spatial or episodic memory task\u002Fcompletion.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Patient receives a dose of saline via IV fifteen minutes prior to spatial or episodic memory task\u002Fcompletion.",[15],[30],{"name":31,"affiliation":5,"role":32},"Bradley C Lega, MD","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Bradley Lega, MD","CONTACT","214-648-7816","Bradley.Lega@UTSouthwestern.edu",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Dallas","Texas","75390","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-96.80667,32.78306,{"lat":51,"lon":50},[54],{"name":31,"role":36,"phone":55,"phoneExt":25,"email":56},"(713) 834-2497","bradley.lega@utsouthwestern.edu",{"type":32,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Bradley Lega","ASSOC PROFESSOR - Neurological Surgery",[61],{"name":62,"class":63},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH","100484896","early-phase-1-pharmacological-modulation-of-brain-oscillations-in-memory-processing-100484896",false,"NCT05594017","Pharmacological Modulation of Brain Oscillations in Memory Processing","Behavioral and Pharmacological Manipulation of Time Cell Activity in the Human Mesial Temporal Lobe","Patient inclusion criteria:\n\n1. Age 18 - 55 years, all races\u002Fethnicities, and both genders are eligible.\n2. Candidates for pre-operative evaluation using stereo intracranial electrodes and admission to the Epilepsy Monitoring Unit (EMU) as determined independently by the patient's treating physician as part of the patient's routine medical care.\n3. Able to read, understand, and provide written, dated informed consent prior to screening.\n4. In good general health, aside from a history of epilepsy, as ascertained by medical history, physical examination (PE), clinical laboratory evaluations, and ECG.\n5. Body mass index between 18-35 kg\u002Fm2.\n\nPatient exclusion criteria:\n\n1. Has a clinically significant abnormality on the screening physical examination that might affect safety, study participation, or confound interpretation of study results according to the study physician.\n2. Female that is pregnant, breastfeeding, or has a positive pregnancy test at screening or baseline. Note that pregnant patients are excluded from undergoing iEEG generally and all patients undergo a positive screening urine test for drugs of abuse at screening: cannabinoids, cocaine, amphetamines, barbiturates, opiates not otherwise explained by their prescribed medications.\n3. History of renal insufficiency.\n4. Unstable cardiac syndrome or active cardiac symptoms.\n5. Patients with liver failure.\n6. Patients with BPH.\n7. Patients with autoimmune neuropathy.\n8. Patients with uncontrolled hyperthyroidism.\n9. Patients with a history of dementia.\n10. Patient with a history of delirium after using transdermal scopolamine.\n11. History of narrow-angle glaucoma.\n12. History of pyloric obstruction or paralytic ileus.\n13. History of myasthenia gravis, obstructive uropathy, porphyria, or myasthenia gravis.",true,"ALL","18 Years","55 Years",{"count":76,"type":77},60,"ESTIMATED","INTERVENTIONAL",[80],"EARLY_PHASE1","The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed.\n\nThe main questions it aims to answer are 1) whether scopolamine changes memory activity solely at encoding (the time when the person perceives and determines to remember an item or event) as has previously been found, or if it also can selectively impact retrieval (when the item or event which has been processed is recalled or remembered), and 2) what the nature of the brain activity changes is.\n\nParticipants will complete two treatment arms. One of these will be with the drug, and the other will be with a saline solution, so that the participants are unaware which session the actual drug has been received. Patients will complete a verbal and\u002For spatial task each of the two days. An anesthesiologist will administer either the drug or the saline at a critical point which addresses both of the research questions.\n\nResearchers will compare the brain activity between the two treatment arms to determine what brain activity changes, and at what time point during memory formation.",[83,84,85,86,87],"Epilepsy","Seizures","Cognitive Impairment, Mild","Memory Disorders","Memory Loss",[89,90,91],"oscillatory changes","cholinergic antagonist","muscarinic antagonist","2025-09-29",{"date":94,"type":95},"2025-10-03","ACTUAL",{"date":97,"type":95},"2019-08-01",{"date":99,"type":77},"2027-05-31",{"name":5,"class":6},1]