[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100493226":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":37,"locations":43,"responsibleParty":60,"collaborators":27,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":27,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":27,"enrollmentInfo":71,"targetDuration":27,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":27,"overallStatus":45,"whyStopped":27,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Rhode Island Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Vitamin A & Nicotinamide","EXPERIMENTAL","1,000 μg retinyl palmitate and 500 mg NAM twice a day",[13,14],"Drug: Vitamin A","Drug: Nicotinamide",{"label":16,"type":17,"description":18,"interventionNames":19},"Placebo","PLACEBO_COMPARATOR","Identical placebo pills twice a day",[20],"Other: Other: Placebo",[22,28,34],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Vitamin A","1,000 μg retinyl palmitate twice a day for 6 months",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Nicotinamide","500 mg NAM twice a day for 6 months",[9],[33],"Niacin (Vitamin B3)",{"type":6,"name":35,"description":18,"armGroupLabels":36,"otherNames":27},"Other: Placebo",[16],[38],{"name":39,"role":40,"phone":41,"phoneExt":27,"email":42},"Eunyoung Cho, ScD","CONTACT","401-863-5895","Eunyoung_Cho@brown.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Providence","Rhode Island","02912","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-71.41283,41.82399,{"lat":55,"lon":54},[58],{"name":59,"role":40,"phone":41,"phoneExt":27,"email":42},"Eunyoung Cho",{"type":61,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100493226","early-phase-1-pilot-trial-of-supplemental-vitamin-a-and-nicotinamide-100493226",false,"NCT05702398","Pilot Trial of Supplemental Vitamin A and Nicotinamide","Pilot Trial of Supplemental Vitamin A and Nicotinamide and Levels of Blood Vitamin A and Nicotinamide","Inclusion Criteria:\n\n* 18 years old or greater;\n* Either History of 2 or more histologically confirmed invasive cutaneous SCCs in the past 2 years or\n* At least one previously billed Healthcare Common Procedure Coding System code 17004 (destruction of 15 or more benign or premalignant lesions of the integumentary system);\n* Understands, reads, and writes English proficiently.\n\nExclusion Criteria:\n\n* Liver disease;\n* Active peptic ulcer disease;\n* Recent myocardial infarction;\n* Hypotension;\n* Internal malignancy within past 5 years;\n* Renal impairment with eGFR\\\u003C15 mL\u002Fmin\u002F1.73 m2;\n* Being unable for follow up due to social reasons;\n* Gorlin's syndrome or other genetic skin cancer syndrome;\n* Huge number of current skin cancers;\n* Metastatic SCC or invasive melanoma within the past 5 years;\n* Pregnancy or lactation;\n* Need for ongoing carbamazepine use (which could have a possible interaction with NAM);\n* Use of acitretin or other oral retinoids within the past 6 months;\n* Use of supplemental NAM, niacin, vitamin A, or beta carotene within the past 6 months;\n* Field treatment for actinic keratoses (AKs) within the previous 4 weeks;\n* Use of topical steroids.","ALL","18 Years",{"count":72,"type":73},30,"ESTIMATED","INTERVENTIONAL",[76],"EARLY_PHASE1","The goal of this clinical trial is to assess the feasibility and safety of oral nicotinamide (NAM; a derivative of vitamin B3 \\[niacin\\]) and vitamin A in a high-risk population of kidney transplant recipients with a history of skin cancer to generate preliminary data for future cancer prevention clinical trials.",[79,80],"Skin Cancer","Kidney Transplant Recipients","2026-03-18",{"date":83,"type":84},"2026-03-20","ACTUAL",{"date":86,"type":84},"2023-04-01",{"date":88,"type":73},"2028-03-01",{"name":5,"class":6},1]