[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592870":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":42,"locations":51,"responsibleParty":68,"collaborators":32,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":32,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":32,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":53,"whyStopped":32,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University of Central Florida","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Effusion Group","EXPERIMENTAL","60 mL sterile saline injected into knee",[13],"Device: Joint Effusion via 60 mL Sterile Saline",{"label":15,"type":16,"description":17,"interventionNames":18},"Deafferentation Group","ACTIVE_COMPARATOR","Lidocaine (single intra-articular dose)",[19],"Drug: Intra-articular Lidocaine",{"label":21,"type":22,"description":23,"interventionNames":24},"Control Group","SHAM_COMPARATOR","Sham procedure with fake needle",[25],"Other: Sham injection",[27,33,38],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Joint Effusion via 60 mL Sterile Saline","Injection of sterile saline into the knee joint to simulate joint swelling and induce quadriceps inhibition.",[9],null,{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":32},"DRUG","Intra-articular Lidocaine","Injection of 7 mL lidocaine into the knee joint to simulate deafferentation by temporarily blocking sensory input.",[15],{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":32},"Sham injection","Simulated knee injection using a stage needle without skin penetration, used to blind participants and serve as control.",[21],[43,48],{"name":44,"role":45,"phone":46,"phoneExt":32,"email":47},"Grant Norte, Ph.D.","CONTACT","407-823-3188","Grant.Norte@ucf.edu",{"name":49,"role":45,"phone":32,"phoneExt":32,"email":50},"Meredith Chaput, Ph.D.","Meredith.Chaput@ucf.edu",[52],{"facility":5,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"RECRUITING","Orlando","Florida","32816","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-81.37924,28.53834,{"lat":63,"lon":62},[66],{"name":67,"role":45,"phone":46,"phoneExt":32,"email":47},"Grant E. Norte",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Grant Norte","Associate Professor","100592870","early-phase-1-quadriceps-motor-unit-adaptation-to-simulated-knee-injury-100592870",false,"NCT06999057","Quadriceps Motor Unit Adaptation to Simulated Knee Injury","Inclusion Criteria:\n\n1. Age 18-30 years\n2. Physically active (Tegner ≥ 5)\n3. No prior lower-limb surgery or major injury\n\nExclusion Criteria:\n\n1. Lower limb surgery or significant injury in past 2 years\n2. Cardiopulmonary, neurological, or psychiatric disorders\n3. Needle\u002Felectrical stimulation anxiety\n4. Medications affecting neuromuscular or psychological function\n5. Pregnancy\n6. Allergic to lidocaine\n7. Inability to elicit Hoffmann reflex",true,"ALL","18 Years","30 Years",{"count":83,"type":84},45,"ESTIMATED","INTERVENTIONAL",[87],"EARLY_PHASE1","This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.",[90,91],"Muscle Inhibition","Knee Injury Simulation",[93,94,95,96,97,98,99,100],"Quadriceps","Electromyography","Motor Unit","Knee Effusion","Lidocaine","Deafferentation","Neuromuscular Adaptation","Muscle Strength","2026-04-27",{"date":103,"type":104},"2026-05-01","ACTUAL",{"date":106,"type":84},"2026-08-01",{"date":108,"type":84},"2027-08-01",{"name":5,"class":6},1]