[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593935":3},{"organization":4,"armGroups":7,"interventions":32,"overallOfficials":38,"centralContacts":38,"locations":47,"responsibleParty":66,"collaborators":38,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":38,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":38,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":94,"whyStopped":38,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Second Hospital of Shanxi Medical University","OTHER",[8,14,19,24,28],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A (remimazolam induction group)","EXPERIMENTAL","The ED50 of group A was calculated by sequential method",[13],"Drug: Etomidate",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B (etomidate induction group)","The ED50 of group B was calculated by sequential method",[18],"Drug: Remimazolam",{"label":20,"type":10,"description":21,"interventionNames":22},"group C (0.25ED50 remimazolam +0.75ED50 etomidate)","The ED50 of etomidate in group C were calculated by sequential method.",[23],"Drug: Remimazolam-etomidate",{"label":25,"type":10,"description":26,"interventionNames":27},"Group D (0.5ED50 remimazolam +0.5ED50 etomidate)","The ED50 of etomidate in group Dwere calculated by sequential method.",[23],{"label":29,"type":10,"description":30,"interventionNames":31},"Group E (0.75ED50 remimazolam +0.25 etomidate)","The ED50 of etomidate in group E were calculated by sequential method.",[23],[33,39,43],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"DRUG","Etomidate","Group A was induced with etomidate, the initial dose was 0.120mg\u002Fkg, and the ratio of adjacent doses was 1:0.6",[9],null,{"type":34,"name":40,"description":41,"armGroupLabels":42,"otherNames":38},"Remimazolam","Group B was induced with remimazolam, the initial dose was 0.20mg\u002Fkg, and the ratio of adjacent doses was 1:0.8",[15],{"type":34,"name":44,"description":45,"armGroupLabels":46,"otherNames":38},"Remimazolam-etomidate","In group C, 0.25ED50 remimazolam +0.75ED50 etomidate was used as the initial measurement In group D, 0.5ED50 remimazolam +0.5ED50 etomidate was used as the initial measurement In group E, 0.75ED50 of remimazolam +0.25ED50 of etomidate was used as the initial measurement",[25,29,20],[48],{"facility":5,"status":38,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Taiyuan","Shanxi","030001","China","CN",{"type":55,"coordinates":56},"Point",[57,58],112.56028,37.86944,{"lat":58,"lon":57},[61],{"name":62,"role":63,"phone":64,"phoneExt":38,"email":65},"Zheng Guo M.B.,Ph.D.","CONTACT","+863513365790","guozheng713@yahoo.com",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"PRINCIPAL_INVESTIGATOR","Zheng Guo","professor","100593935","early-phase-1-relationship-between-remimazolam-and-etomidate-in-induction-of-general-anesthesia-100593935",false,"NCT07012902","Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia","The Interaction Between Remimazolam and Etomidate During Induction of General Anesthesia Was Studied by Isoradiometric Analysis","Inclusion Criteria:\n\n1. Both sexes\n2. aged 18-60 yr\n3. ASA physical status I-II\n4. BIM: 18-28kg\u002Fm²\n\nExclusion Criteria:\n\n1. allergic to remimazolam and etomidate\n2. in pregnancy or lactation\n3. serious cardiovascular diseases, long-term alcoholism\n4. used sedative drugs or opioids within 24 hours\n5. severe mental illness and myasthenia gravis -","ALL","18 Years","60 Years",{"count":81,"type":82},125,"ESTIMATED","INTERVENTIONAL",[85],"EARLY_PHASE1","In modern anesthesia practice, anesthesiologists often need to choose a combination of multiple drugs according to the specific conditions and surgical needs of patients, which can not only achieve more fine anesthesia management, but also improve perioperative safety and patient comfort. In clinical practice, anesthesiologists will use etomidate combined with a small dose of remimazolam for anesthesia induction to obtain more stable hemodynamics, prevent intraoperative awareness, and relieve anxiety.However, what is the best dose ratio of etomidate combined with remimazolam, the current literature does not give clear indicators.",[88,89],"Induction Anesthesia","Drug Interactions",[91,92,93],"Isoradiation analysis","etomidate","remimazolam","NOT_YET_RECRUITING","2025-06-08",{"date":97,"type":98},"2025-06-10","ACTUAL",{"date":100,"type":82},"2025-06-12",{"date":102,"type":82},"2025-07-19",{"name":5,"class":6},1]