[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638323":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":26,"locations":36,"responsibleParty":56,"collaborators":59,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":31,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":31,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":86,"whyStopped":31,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Spaulding Rehabilitation Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Participants will be instructed to take Telmisartan, Cilostazol IR (immediate release), and Metformin ER (extended release) (herein referred to as \"proposed pharmacotherapy\") while undergoing robot-assisted upper-extremity training. Participants will take these medications either once a day (QD) or twice a day (BID) as described in the protocol.",[13],"Drug: Telmisartan, Metformin, Cilostazol",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Telmisartan, Metformin, Cilostazol","Participants will be instructed to take the low dose of the proposed pharmacotherapy (i.e., Telmisartan 20mg QD, Metformin ER 500mg QD, Cilostazol IR 50mg QD) during week 1 and the full dose (i.e., Telmisartan 40mg QD, Metformin ER 500mg BID, Cilostazol IR 50mg BID) starting on week 2. They will continue to take the full dose until completion of the six-week robot assessed upper extremity training period (week 3-8). At the end of this period, they will be instructed to take the low dose of the proposed pharmacotherapy for two more weeks. During the entire study, participants will be monitored for potential side-effects.",[9],[21],"Proposed pharmacotherapy",[23],{"name":24,"affiliation":5,"role":25},"Qing M Wang, MD, PhD","PRINCIPAL_INVESTIGATOR",[27,33],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},"Madison Costa, OT","CONTACT","617-952-6388",null,"mcosta11@mgb.org",{"name":34,"role":29,"phone":30,"phoneExt":31,"email":35},"Erin Foley, OT","efoley14@mgb.org",[37],{"facility":5,"status":31,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Charlestown","Massachusetts","02129","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-71.062,42.37787,{"lat":47,"lon":46},[50,53],{"name":51,"role":29,"phone":30,"phoneExt":31,"email":52},"Paolo Bonato, PhD","pbonato@mgh.harvard.edu",{"name":54,"role":29,"phone":30,"phoneExt":31,"email":55},"Federico De Carlo, MS","fdecarlo@mgb.org",{"type":25,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Qing Mei Wang, M.D.","Director of the Stroke Biological Recovery Laboratory",[60],{"name":61,"class":62},"Neuro-Innovators, Inc.","INDUSTRY","100638323","early-phase-1-relying-on-pharmacotherapy-to-improve-motor-gains-in-chronic-stroke-survivors-100638323",false,"NCT07588932","Relying on Pharmacotherapy to Improve Motor Gains in Chronic Stroke Survivors","Relying on Pharmacotherapy to Improve Motor Gains of Robot-Assisted Upper-Extremity Rehabilitation in Chronic Stroke Survivors","Inclusion Criteria:\n\n* Adults between 21 and 80 years of age.\n* History of ischemic stroke.\n* Stroke occurred at least six months prior to recruitment.\n* Moderate to severe UE impairment (FMA-UE score between 15 and 40)\n* MMSE score \\>=20 and being able to safely follow three-step commands.\n\nExclusion Criteria:\n\n* Contraindications to the pharmacotherapy (e.g., heart failure, known medication reaction or interactions with ongoing medication regimen).\n* Taking dual antiplatelet therapy (e.g., Aspirin+Plavix) and\u002For other anticoagulation medications (e.g., Eliquis, coumadin) that cannot safely be modified or discontinued (as determined by the participant's primary care physician or by the medical monitor).\n* Clinically significant somnolence and\u002For depression that would hinder active participation in motor training sessions.\n* Taking any medication that the study physician determines to have a significant drug-drug interaction with Telmisartan, Cilostazol, and\u002For Metformin.\n* Taking Telmisartan, Cilostazol, and\u002For Metformin in a dose that is different from the one used in the study and that cannot be adjusted to match the study dose (as determined by the participant's primary care physician or by the medical monitor).\n* Taking medications with equivalent clinical effect (e.g., BP control) to Telmisartan, Cilostazol, and\u002For Metformin and that cannot be replaced by Telmisartan, Cilostazol, and\u002For Metformin (as determined by the participant's primary care physician or by the medical monitor).\n* A body mass index (BMI) below 25 (as the proposed pharmacotherapy could cause hypoglycemia in participants with normal-low BMI).\n* Severe musculoskeletal pathology or recent fractures affecting the impaired UE that would prevent safe use of the rehabilitation robotic system.\n* Previous diagnosis of neurological diseases other than stroke that would have a negative impact on the response to the rehabilitation intervention (e.g., severe dystonia affecting the UE) or would prevent safe participation in RA UE training (e.g., uncontrolled seizures).\n* Moderate to severe disability due to migraines as determined using the Migraine Disability Assessment test (score \\> 10).\n* Severe spasticity (Modified Ashworth Scale for spasticity ≥ 3 for UE muscles) that would prevent safe use of the robotic system utilized during training.\n* Undergoing Botox treatment for pain\u002Fspasticity related to the affected upper extremity, in the 4 months prior to enrollment or during the study period.\n* Cerebellar and\u002For hemorrhagic stroke.\n* Severe aphasia limiting the ability to express needs or discomfort verbally or non-verbally.\n* Visual impairments that would prevent proper use of interactive on-screen games during RA UE training.\n* Severe hemispatial neglect as assessed using the Line Bisection Test (missed lines \\>2).\n* Severely impaired trunk control that would prevent sitting safely on a chair without arms.\n* Individuals who present with the following on the impaired UE: open wounds, fragile skin, and under contact precautions due to an active infection.\n* Participation in another therapy focused on the recovery of the impaired UE.\n* Subjects with cardiac pacemakers, electronic pumps, or any other implanted medical devices that are not US-certified (and hence might be affected by the electromagnetic interference generated by the robot).\n* Any condition that would prevent proper\u002Fsafe use of the robotic system, such as proprioceptive deficits that impair the ability to process haptic or visual feedback, or unstable shoulder joint as assessed by physical examination.\n* Current pregnancy.","ALL","21 Years","80 Years",{"count":74,"type":75},50,"ESTIMATED","INTERVENTIONAL",[78],"EARLY_PHASE1","The goal of this trial is to study if the concomitant administration of Telmisartan, Cilostazol IR (immediate release), and Metformin ER (extended release) can help stroke survivors make greater gains in movement and recovery during robot-assisted arm and hand rehabilitation.",[81],"Stroke",[81,83,84,85],"Rehabilitation","Pharmacotherapy","Robotic therapy","NOT_YET_RECRUITING","2026-05-14",{"date":89,"type":90},"2026-05-15","ACTUAL",{"date":92,"type":75},"2026-05-18",{"date":94,"type":75},"2028-12-31",{"name":5,"class":6},1]