[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100512003":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":34,"centralContacts":39,"locations":45,"responsibleParty":62,"collaborators":34,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":34,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":34,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":47,"whyStopped":34,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Iowa","OTHER",[8,15,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"local lactated Ringer's perfusion","PLACEBO_COMPARATOR","lactated Ringer's is perfused through the microdialysis fiber to serve as the vehicle control",[13,14],"Drug: Acetylcholine","Drug: Insulin aspart",{"label":16,"type":17,"description":18,"interventionNames":19},"local apocynin perfusion","EXPERIMENTAL","local apocynin is perfused through the microdialysis fiber to serve as the NADPH oxidase inhibited experimental treatment",[13,14],{"label":21,"type":17,"description":22,"interventionNames":23},"local L-NAME perfusion","local L-NAME is perfused through the microdialysis fiber to inhibit nitric oxide synthase",[13,14],{"label":25,"type":17,"description":26,"interventionNames":27},"local apocynin + L-NAME perfusion","local apocynin and L-NAME are perfused through the microdialysis fiber for dual inhibition of NADPH oxidase and nitric oxide synthase",[13,14],[29,35],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DRUG","Acetylcholine","acetylcholine is perfused at 10 ascending concentrations (10\\^-10M - 10\\^-1 M) for 5 minutes each",[21,25,16,9],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Insulin aspart","insulin aspart is perfused at 5 ascending concentrations (10\\^-8M - 10\\^-4 M) for 10 minutes each",[21,25,16,9],[40],{"name":41,"role":42,"phone":43,"phoneExt":34,"email":44},"Anna Reid-Stanhewicz, PHD","CONTACT","319-467-1732","anna-stanhewicz@uiowa.edu",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Iowa City","Iowa","52242","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-91.53017,41.66113,{"lat":57,"lon":56},[60],{"name":61,"role":42,"phone":43,"phoneExt":34,"email":44},"Anna Stanhewicz, PhD",{"type":63,"investigatorFullName":61,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"SPONSOR_INVESTIGATOR","Assistant Professor","100512003","early-phase-1-role-of-nadph-oxidase-in-microvascular-dysfunction-following-gdm-100512003",false,"NCT05946798","Role of NADPH Oxidase in Microvascular Dysfunction Following GDM","INCLUSION CRITERIA:\n\n* 18 years or older\n* pregnant within 5 years of the study visit\n* had gestational diabetes diagnosed by their obstetrician and confirmed according to the American College of Obstetricians and Gynecologists criteria for gestational diabetes.\n* or without a history of gestational diabetes\n\nEXCLUSION CRITERIA:\n\n* skin diseases\n* current tobacco or electronic cigarette\u002Fvape pen use,\n* diagnosed or suspected hepatic or metabolic disease including diabetes,\n* statin or other cholesterol-lowering medication,\n* current antihypertensive medication,\n* history of preeclampsia or gestational hypertension,\n* current pregnancy,\n* body mass index \\\u003C18.5 kg\u002Fm2,\n* allergy to materials used during the experiment.(e.g. latex),\n* known allergies to study drugs",true,"FEMALE","18 Years","50 Years",{"count":76,"type":77},40,"ESTIMATED","INTERVENTIONAL",[80],"EARLY_PHASE1","The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.",[83,84,85],"Gestational Diabetes","Oxidative Stress","Vascular Endothelial Function",[87,88,89],"gestational diabetes","postpartum","vascular","2025-05-07",{"date":92,"type":93},"2025-05-13","ACTUAL",{"date":95,"type":93},"2023-08-30",{"date":97,"type":77},"2028-06-01",{"name":61,"class":6},1]