[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614902":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":61,"collaborators":20,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":20,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":20,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Minicircle","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention with Cognitive\u002FHealth battery before and after","EXPERIMENTAL","This arm includes cognitive and health battery pre- and post-intervention of the gene therapy",[13],"Genetic: Follistatin and klotho gene therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"GENETIC","Follistatin and klotho gene therapy","Injection of nonviral plasmid-delivered follistatin and klotho gene therapy",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Mac Davis","CONTACT","512-630-0882","coordinator@minicircle.io",[28,44],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Apeiron Center","RECRUITING","Austin","Texas","78701","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-97.74306,30.26715,{"lat":40,"lon":39},[43],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"facility":45,"status":46,"city":47,"state":48,"zip":20,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Global Alliance of Regenerative Medicine (GARM) Clinic","NOT_YET_RECRUITING","Roatán","Bay Islands","Honduras","HN",{"type":37,"coordinates":52},[53,54],-86.53605,16.3229,{"lat":54,"lon":53},[57],{"name":58,"role":24,"phone":59,"phoneExt":20,"email":60},"Mayra Hoch","+504 2408-3544","mayra@garmclinic.com",{"type":62,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100614902","early-phase-1-safety-and-efficacy-of-klotho-and-follistatin-gene-therapy-100614902",false,"NCT07285629","Safety and Efficacy of Klotho and Follistatin Gene Therapy","Evaluating the Safety and Efficacy of Injectable Combination Klotho and Follistatin Plasmid Gene Therapy in Humans -- An Interventional, Non-Placebo Controlled Pilot Phase Study","Inclusion Criteria:\n\n* Adults aged 50 to 80 years\n* General good health\n* Willing to comply with all study-related procedures and visits\n* Participant is open to morphological change\n* If female, participant agrees to maintain contraception\n* If female, participant agrees to take a pregnancy test\n* If female, participant agrees to a pregnancy waiver\n\nExclusion Criteria:\n\n* Currently enrolled in another clinical trial\n* History of cancer, autoimmune disease, or chronic kidney\u002Fliver disease\n* Use of immunosuppressive therapy\n* Pregnant or breastfeeding\n* Women of childbearing potential who are unwilling or unable to use effective contraception for the duration of the study.\n* Regular use of NMDA (N-methyl-D-aspartate) antagonists (i.e., memantine, ketamine, etc.)\n* Regular use of antiplatelet medications (i.e., aspirin)\n* Any medical or psychiatric condition that could interfere with participation or pose safety concerns\n* Unwilling or unable to provide informed consent",true,"ALL","50 Years","80 Years",{"count":75,"type":76},30,"ESTIMATED","INTERVENTIONAL",[79],"EARLY_PHASE1","The purpose of this study is to investigate the safety and efficacy of a combination klotho and follistatin gene therapy, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of this gene therapy.",[82],"Healthy Adults",[84,85,86,87,88],"klotho","follistatin","nonviral","gene therapy","plasmid","2026-01-06",{"date":91,"type":92},"2026-01-08","ACTUAL",{"date":94,"type":92},"2025-12-16",{"date":96,"type":76},"2026-06",{"name":5,"class":6},2]