[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100456147":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":35,"centralContacts":39,"locations":45,"responsibleParty":64,"collaborators":22,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":22,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":22,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":22,"overallStatus":48,"whyStopped":22,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Hypoxia Exposure","Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.",[12,13,14,15],"Drug: Propranolol Hydrochloride","Drug: Isoproterenol","Drug: Phentolamine Mesylate","Drug: Norepinephrine",[17,23,27,31],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DRUG","Propranolol Hydrochloride","Regional forearm blockade of β-adrenergic receptors at 20 mcg\u002FdL\u002Fmin via brachial artery catheter during normoxia and hypoxia exposures",[9],null,{"type":18,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"Isoproterenol","Dose response (1, 3, 6, and 12 ng\u002FdL\u002Fmin) regional infusion to assess β-adrenergic receptor responsiveness",[9],{"type":18,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"Phentolamine Mesylate","This infusion will be for 10 min before baseline measurement (12 mcg\u002FdL\u002Fmin) and continue the infusion at a maintenance rate (5 mcg\u002FdL\u002Fmin).",[9],{"type":18,"name":32,"description":33,"armGroupLabels":34,"otherNames":22},"Norepinephrine","Regional forearm infusion at 8 ng\u002FdL\u002Fmin via brachial artery catheter during normoxia and hypoxia exposures",[9],[36],{"name":37,"affiliation":5,"role":38},"Jacqueline Limberg, Ph.D.","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":22,"email":44},"Jacqueline K Limberg, Ph.D.","CONTACT","5738822544","limbergj@missouri.edu",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"University of Missouri","RECRUITING","Columbia","Missouri","65211","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-92.33407,38.95171,{"lat":58,"lon":57},[61],{"name":62,"role":42,"phone":43,"phoneExt":22,"email":63},"Jennifer L Harper","harperjl@missouri.edu",{"type":38,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Jacqueline K Limberg, PhD","Assistant Professor","100456147","early-phase-1-sex-disparities-in-hypoxic-vasodilation-and-impact-of-obesity-100456147",false,"NCT05219799","Sex Disparities in Hypoxic Vasodilation and Impact of Obesity","Inclusion Criteria:\n\n* BMI \\>18 kg\u002Fm2\n\nExclusion Criteria:\n\n* Pregnancy, breastfeeding\n* Diagnosed sleep apnea or AHI \\>10 events\u002Fhr\n* Current smoking\u002FNicotine use\n* Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy\n* Nerve\u002Fneurologic disease\n* Cardiovascular, hepatic, renal, respiratory disease\n* Blood pressure ≥140\u002F90 mmHg\n* Diabetes, Polycystic ovarian syndrome\n* Communication barriers\n* Prescription medications, Sensitivity to lidocaine",true,"ALL","18 Years","45 Years",{"count":78,"type":79},72,"ESTIMATED","INTERVENTIONAL",[82],"EARLY_PHASE1","The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.",[85,86,87],"Obesity","Vasodilation","Healthy","2025-05-22",{"date":90,"type":91},"2025-05-29","ACTUAL",{"date":93,"type":91},"2023-03-14",{"date":95,"type":79},"2026-06-30",{"name":5,"class":6},1]