[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603947":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":54,"collaborators":11,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":11,"eligibilityCriteria":62,"healthyVolunteers":59,"sex":63,"minAge":64,"maxAge":11,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":38,"whyStopped":11,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Colchicine group","ACTIVE_COMPARATOR",null,[13],"Drug: Colchicine",{"label":15,"type":16,"description":11,"interventionNames":17},"Control group","PLACEBO_COMPARATOR",[18],"Drug: Placebo",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Colchicine","Administration of Colchicine 1 day before and 90 days after PCI in Non-STEMI Patients",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Placebo","Matching Placebo Regimen",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Resident Doctor","CONTACT","+201272615212","david.17289616@med.aun.edu.eg",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":11,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Assiut University Hospitals","RECRUITING","Asyut","Asyut Governorate","Egypt","EG",{"type":44,"coordinates":45},"Point",[46,47],31.18368,27.18096,{"lat":47,"lon":46},[50],{"name":51,"role":32,"phone":52,"phoneExt":11,"email":53},"Vice president of graduate studies of Assiut University","+2088 22080150","vp_grad@aun.edu.eg",{"type":55,"investigatorFullName":56,"investigatorTitle":31,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","David Gamal William Ibrahim","100603947","early-phase-1-short-term-outcomes-of-early-administration-of-colchicine-in-non-st-segment-elevation-myocardial-infarction-patients-treated-with-drug-eluting-stents-100603947",false,"NCT07143136","Short-Term Outcomes of Early Administration of Colchicine in Non-ST Segment Elevation Myocardial Infarction Patients Treated With Drug-Eluting Stents.","Inclusion Criteria:\n\n* Diagnosed with Non-STEMI\n* Undergoing PCI with drug-eluting stents\n\nExclusion Criteria:\n\n* Severe renal or hepatic dysfunction\n* Colchicine hypersensitivity\n* Active infection and active diarrhea.\n* Gastrointestinal intolerance\n* Pregnancy or breastfeeding.\n* Cardiogenic shock","ALL","18 Years",{"count":66,"type":67},140,"ESTIMATED","INTERVENTIONAL",[70],"EARLY_PHASE1","Inflammation plays a central role in the pathophysiology of atherosclerosis and in the progression of coronary artery. Colchicine, an anti-inflammatory agent traditionally used for gout and pericarditis, has emerged as a potential therapy in cardiovascular disease due to its ability to inhibit microtubule polymerization and suppress interleukin-1β and the NLRP3 inflammasome pathway.\n\nCOLCOT and LoDoCo2 trails have demonstrated the efficacy of colchicine in reducing cardiovascular events in patients with coronary artery disease.\n\nHowever, more recent trials, including OASIS 9 and COVERT-MI trials did not support the use of a short-term colchicine treatment at the acute phase of ST segment elevation myocardial infarction (STEMI) to reduce infarct size and improve outcomes. Limited data exist on the peri-procedural use of colchicine in non-ST elevation myocardial infarction patients undergoing PCI.\n\nThis study proposes to assess whether a loading dose of colchicine before PCI, followed by 3-months maintenance therapy, can improve short-term clinical outcomes and inflammatory markers in non- STEMI patients.",[73],"Non ST-Segment Elevation Myocardial Infarction",[22,75,76],"Inflammation","Non-STEMI","2025-08-19",{"date":79,"type":80},"2025-08-27","ACTUAL",{"date":82,"type":80},"2025-08-10",{"date":84,"type":67},"2026-09",{"name":5,"class":6},1]