[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611579":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":24,"locations":30,"responsibleParty":57,"collaborators":23,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":23,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":23,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":33,"whyStopped":23,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Beijing GoBroad Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"TC-G203 Cell Therapy","EXPERIMENTAL","TC-G203 CAR-T Cells Following lymphodepletion chemotherapy, participants will receive TC-G203 CAR-T cell infusion.",[13],"Biological: TC-G203 cells treatment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BIOLOGICAL","TC-G203 cells treatment","TC-G203 CAR-T cells Treatment follows a lymphodepletion Drug: Fludarabine and Cyclophosphamide.",[9],[21,22],"Cyclophosphamide","Fludarabine",null,[25],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},"Changsong Qi","CONTACT","+8601050847838","xiwangpku@126.com",[31,48],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Beijing Gobroad Hospital","RECRUITING","Beijing","Beijing Municipality","100000","China","CN",{"type":40,"coordinates":41},"Point",[42,43],116.39723,39.9075,{"lat":43,"lon":42},[46],{"name":47,"role":27,"phone":23,"phoneExt":28,"email":29},"Qi Changsong Beijing Goabroad Hospital",{"facility":49,"status":50,"city":34,"state":35,"zip":51,"country":37,"countryCode":38,"cosmosGeoPoint":52,"geoPoint":54,"contacts":55},"GoBroad Healthcare Group","NOT_YET_RECRUITING","102206",{"type":40,"coordinates":53},[42,43],{"lat":43,"lon":42},[56],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},{"type":58,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100611579","early-phase-1-tc-g203-for-patients-with-gpc3-positive-advanced-solid-tumors-100611579",false,"NCT07242417","TC-G203 for Patients With GPC3-Positive Advanced Solid Tumors","A Preliminary Clinical Study of TC-G203 for Patients With GPC3-Positive Recurrent\u002FMetastatic Solid Tumors","Inclusion Criteria:\n\n1. Participants must voluntarily provide written informed consent.\n2. Aged 18-75 years (inclusive).\n3. Life expectancy ≥ 12 weeks.\n4. ECOG performance status 0-1.\n5. Failed or unsuitable for standard therapy.\n6. At least one measurable lesion per RECIST 1.1.\n7. GPC3-positive tumor confirmed by immunohistochemistry.\n8. Adequate organ and bone marrow function.\n9. Effective contraception required for participants of childbearing potential.\n10. Adequate venous access for leukapheresis.\n\nExclusion Criteria:\n\n1. Primary CNS malignancy or uncontrolled CNS metastases.\n2. Other malignancies within 5 years\n3. Active autoimmune disease or history of autoimmune disease.\n4. Immunodeficiency, including HIV positivity\n5. Bleeding disorders (inherited or acquired).\n6. Clinically significant cardiovascular disease.\n7. Active infection (including tuberculosis, hepatitis C, syphilis).\n8. Pregnant or breastfeeding women.\n9. Severe systemic or psychiatric illness.\n10. Prior cell or gene therapy.\n11. Severe drug hypersensitivity history.\n12. Investigator-assessed unsuitability for trial participation. -","ALL","18 Years","75 Years",{"count":70,"type":71},30,"ESTIMATED","INTERVENTIONAL",[74],"EARLY_PHASE1","This is a single-arm, open-label, dose-escalation clinical trial designed to evaluate the safety, tolerability, expansion, and persistence of TC-G203 in patients with GPC3-positive recurrent or metastatic solid tumors who have progressed after prior therapies. The primary objective is to determine the maximum tolerated dose (MTD), with a secondary aim to assess preliminary clinical efficacy in solid tumors.",[77,78],"Solid Cancer","GPC3 Positive Hepatocellular Carcinoma",[77,80],"GPC3 positive hepatocellular carcinoma","2026-01-19",{"date":83,"type":84},"2026-01-21","ACTUAL",{"date":86,"type":84},"2025-12-18",{"date":88,"type":71},"2027-11-01",{"name":5,"class":6},2]