[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100428168":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":49,"locations":30,"responsibleParty":59,"collaborators":62,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":30,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":30,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":97,"whyStopped":30,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":30},{"fullName":5,"class":6},"Hartford Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Occasional Users - High THC and High CBD Dose","EXPERIMENTAL","People who smoke marijuana occasionally will be given a dose of high THC high CBD marijuana at the study visit",[13],"Drug: High THC\u002FHigh CBD Marihuana",{"label":15,"type":10,"description":16,"interventionNames":17},"Occasional Users - High THC and No CBD Dose","People who smoke marijuana occasionally will be given a dose of high THC and no CBD marijuana at the study visit",[18],"Drug: High THC\u002FNo CBD Marihuana",{"label":20,"type":10,"description":21,"interventionNames":22},"Occasional Users - No THC and No CBD Dose","People who smoke marijuana occasionally will be given a dose of marijuana that contains no THC or CBD",[23],"Drug: No THC\u002FNo CBD Marihuana",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","High THC\u002FNo CBD Marihuana","high THC (65 mg THC) and no CBD (0 mg CBD)",[15],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"High THC\u002FHigh CBD Marihuana","high THC (65 mg THC) and high CBD (50 mg CBD)",[9],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"No THC\u002FNo CBD Marihuana","no THC (0 mg THC) and no CBD (0 mg CBD); placebo drug",[20],[40,44,46],{"name":41,"affiliation":42,"role":43},"Godfrey Pearlson, MD","Hartford Hospital - Olin Neuropsychiatry Research Center; Yale University","PRINCIPAL_INVESTIGATOR",{"name":45,"affiliation":42,"role":43},"Alecia Dager, PhD",{"name":47,"affiliation":48,"role":43},"Michael Stevens, PhD","Hartford Hospital - Olin Neuropsychiatry Research Center",[50,55],{"name":51,"role":52,"phone":53,"phoneExt":30,"email":54},"Chelsea N Meagher, BA","CONTACT","860-545-7106","chelsea.meagher@hhchealth.org",{"name":56,"role":52,"phone":57,"phoneExt":30,"email":58},"Diana G King, BA","860-545-7563","diana.king@hhchealth.org",{"type":43,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Godfrey Pearlson","Founding Director Olin Neuropsychiatry Research Center; Professor Yale University",[63],{"name":64,"class":6},"Yale University","100428168","early-phase-1-thc--cbd-and-memory-study-100428168",false,"NCT04855526","THC + CBD and Memory Study","Effects of Marijuana on Memory-Related Neurochemistry and Neural Response","Inclusion Criteria:\n\n* Right-handed\n* Prior MJ users (has used MJ at least once in the past year, but no more than 1x\u002Fmonth in the past 12 months)\n* Medically healthy (as determined by medical history and treatment)\n* Adequate comprehension of English in order to complete study materials\n* Acceptable birth control method for women (i.e., no copper IUD or any device that is not MRI safe)\n\nExclusion Criteria:\n\n* Participant currently uses psychoactive medications or substances\n* Psychiatric diagnoses (determined by DSM-V)\n* Participant heavily or regularly uses MJ (more than 1x\u002Fmonth in the past year)\n* Current or past substance dependence (including MJ)\n* Positive urine toxicology screens\n* Positive pregnancy screens\n* MRI contraindications (e.g., heart pacemaker)",true,"ALL","18 Years","40 Years",{"count":77,"type":78},9,"ESTIMATED","INTERVENTIONAL",[81],"EARLY_PHASE1","Memory deficits are one of the most consistently observed cognitive effects of marijuana use. There is evidence that some decrements attributable to the primary psychoactive ingredient, delta-9-tetrahydrocannabinol (THC), may be attenuated by cannabidiol (CBD). This study will help us learn more about the relationship between THC and CBD consumption with memory processes. A combination of MRI and neuropsychological tests (which are computer and paper\u002Fpencil tasks) will be used to measure the neurocognitive and behavioral impacts of THC and CBD use.",[84,85,86],"Marijuana Use","Cannabis Use","Cannabis Intoxication",[88,89,90,91,92,93,94,95,96],"marijuana","cannabidiol","memory","THC","cannabis","intoxication","MRI","glutamate","MRS","NOT_YET_RECRUITING","2025-03-13",{"date":100,"type":101},"2025-03-17","ACTUAL",{"date":103,"type":78},"2025-12-01",{"date":105,"type":78},"2026-12-30",{"name":5,"class":6}]