[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591692":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":64,"collaborators":67,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":34,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":34,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":38,"whyStopped":34,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Beth Israel Deaconess Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Vitamin B3, then placebo","EXPERIMENTAL","Individuals will receive 1000mg oral Vitamin B3 daily for two days leading up to their first exercise session, and oral placebo daily for two days leading up to their second exercise session.",[13],"Dietary Supplement: Vitamin B3",{"label":15,"type":10,"description":16,"interventionNames":17},"Placebo, then vitamin B3","Individuals will receive 1000mg oral placebo daily for two days leading up to their first exercise session, and oral vitamin B3 daily for two days leading up to their second exercise session.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT","Vitamin B3","1000mg once a day orally for two days, once the day before the exercise session, and once the day of the exercise session.",[15,9],[25],"niacinamide",[27],{"name":28,"affiliation":5,"role":29},"Nathan H Raines, MD MPH","PRINCIPAL_INVESTIGATOR",[31],{"name":28,"role":32,"phone":33,"phoneExt":34,"email":35},"CONTACT","703-927-0992",null,"nraines@bidmc.harvard.edu",[37,53],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Boston","Massachusetts","02215","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-71.05977,42.35843,{"lat":48,"lon":47},[51,52],{"name":28,"role":32,"phone":33,"phoneExt":34,"email":35},{"name":28,"role":29,"phone":34,"phoneExt":34,"email":34},{"facility":54,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":55,"geoPoint":57,"contacts":58},"Boston University",{"type":45,"coordinates":56},[47,48],{"lat":48,"lon":47},[59,63],{"name":60,"role":32,"phone":61,"phoneExt":34,"email":62},"Dustin Allen, PhD","417-693-2182","drallen@bu.edu",{"name":60,"role":29,"phone":34,"phoneExt":34,"email":34},{"type":29,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Nathan Raines","Assistant Professor of Medicine",[68,70],{"name":69,"class":6},"Boston University Charles River Campus",{"name":71,"class":72},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100591692","early-phase-1-the-kidneys-response-to-exercise-in-heat-and-the-impact-of-vitamin-b3-on-this-response-100591692",false,"NCT06983730","The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response","Development of a Clinical Experimental Heat Stress Protocol and Exploration of the Effect of Niacinamide on Physiologic, Metabolic, and Biochemical Responses to Heat Stress","Inclusion Criteria:\n\n* Healthy volunteer\n* Any race\n* Estimated glomerular filtration rate greater than 90 ml\u002Fmin\u002F1.73m2\n* Urine albumin\u002Fcreatinine ratio less than 30mg\u002Fg\n* Nonsmoker\n* No regular dietary supplements, particularly vitamin B3\n* Physically fit, defined as having a VO2 max of between 35 and 60mL\u002Fkg\u002Fmin\n\nExclusion Criteria:\n\n* Medical condition preventing safe participation in exercise during heat\n* Allergy to Vitamin B3\n* Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications",true,"ALL","18 Years","45 Years",{"count":85,"type":86},28,"ESTIMATED","INTERVENTIONAL",[89],"EARLY_PHASE1","The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are:\n\n* How do the chemicals produced by the body change under conditions of higher versus lower heat stress?\n* What role does a specific area of the body's metabolism, known as NAD+ metabolism, play in the body's response to heat stress, and can this response be modified by taking vitamin B3?",[92,93,94],"Heat Strain","Healthy Volunteer Study","Kidney Dysfunction",[96,97,21,98],"NAD+","Niacinamide","Experimental heat strain","2026-02-03",{"date":101,"type":102},"2026-02-05","ACTUAL",{"date":104,"type":102},"2026-01-26",{"date":106,"type":86},"2028-06",{"name":5,"class":6},2]