[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627704":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":35,"responsibleParty":55,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":85,"whyStopped":25,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Northern Arizona University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo-control","PLACEBO_COMPARATOR","Exercise with saline injection",[13],"Drug: EXERCISE TRAINING WITH OR WITHOUT MEDICATION",{"label":15,"type":16,"description":17,"interventionNames":18},"Group III\u002FIV afferent blockade","EXPERIMENTAL","Feedback from group III\u002FIV afferents is blocked",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","EXERCISE TRAINING WITH OR WITHOUT MEDICATION","Cycling exercise with group III\u002FIV afferent feedback blocked via drug",[15,9],null,[27],{"name":28,"affiliation":5,"role":29},"TRAVIS D GIBBONS, PhD","PRINCIPAL_INVESTIGATOR",[31],{"name":28,"role":32,"phone":33,"phoneExt":25,"email":34},"CONTACT","19282558769","travis.gibbons@nau.edu",[36],{"facility":5,"status":25,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Flagstaff","Arizona","86011","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-111.65127,35.19807,{"lat":46,"lon":45},[49,51,54],{"name":28,"role":32,"phone":50,"phoneExt":25,"email":34},"9282558769",{"name":52,"role":53,"phone":25,"phoneExt":25,"email":25},"RILEY CONNOR, MS","SUB_INVESTIGATOR",{"name":28,"role":29,"phone":25,"phoneExt":25,"email":25},{"type":56,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100627704","early-phase-1-what-is-the-role-of-type-iiiiv-muscle-afferents-in-airway-resistance-and-thermoregulatory-responses-to-exercise-100627704",false,"NCT07452094","What is the Role of Type III\u002FIV Muscle Afferents in Airway Resistance and Thermoregulatory Responses to Exercise?","Type III\u002FIV Muscle Afferents in Airway and Thermoregulatory Responses","Inclusion Criteria:\n\n* regularly physically active as determined via questionnaires (Par-Q \\& You)\n* maximal aerobic power 30 mL\u002Fmin\u002Fkg (female), 40 mL\u002Fkg\u002Fmin (male)\n\nExclusion Criteria:\n\n* current smokers\n* acute bronchial asthma\n* diabetics\n* chronic back pain\n* peripheral neuropathy\n* chronic obstructive airway or status asthmaticus\n* obese (body mass index \\> 30 kg\u002Fm2)\n* convulsive disorders\n* requiring daily medications that may affect responses to exercise (e.g. anti-hypertensive, anti-arrhythmogenics, blood thinners)\n* history of drug abuse\n* history of disease\u002Fdysfunction that could cause complication with exercise (e.g. cardiovascular, respiratory, neurological, musculoskeletal)\n* irregular or absent menstrual cycle\n* pregnant or suspected pregnancy\n* adverse response to physical exercise\n* current or history of esophageal or gastric disease, or frequent heart burn (\\>2x per week)\n* Lidocaine allergy",true,"ALL","18 Years","40 Years",{"count":69,"type":70},15,"ESTIMATED","INTERVENTIONAL",[73],"EARLY_PHASE1","Exercise places serious demands on the body. These demands are fundamentally caused by increases in oxygen demand and the consequent increase in body temperature. These demands are met by several physiological responses, including increases in heart rate, blood pressure, breathing and blood flow. These responses must be proportional to the increase in demand and some signal must relay information from the muscle to the brain. Group III\u002FIV afferents do just this. They relay information about the muscle (movement, temperature, acidity, etc.) up to the brain so that appropriate responses are mounted. There is strong evidence in animals that group III\u002FIV afferents play a key role in making breathing easier (decreasing airway resistance) and initiating sweating and blood flow responses. There has been no research on the role of group III\u002FIV afferents on these fundamental exercise responses in humans. The investigators propose to isolate the role of group III\u002FIV afferents on regulate airway resistance, sweating and blood flow responses to exercise in humans.",[76,77],"Placebo - Control","Experimental",[79,80,81,82,83,84],"Group III\u002FIV afferents","exercise","thermoregulation","sweating","blood flow","airway resistance","NOT_YET_RECRUITING","2026-02-27",{"date":88,"type":89},"2026-03-05","ACTUAL",{"date":91,"type":70},"2026-04-01",{"date":93,"type":70},"2027-04-01",{"name":5,"class":6},1]