[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100280926":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":80,"collaborators":82,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":93,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":100,"studyType":101,"phases":10,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"University of Kansas Medical Center","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Individuals diagnosed with PKD",null,"Individuals that have been diagnosed and meet the study's definition of early stage PKD.",{"label":13,"type":10,"description":14,"interventionNames":10},"Individuals with a family history of PKD","Unaffected\u002F undiagnosed family members, preferably siblings, of participants with PKD",{"label":16,"type":10,"description":17,"interventionNames":10},"Normal individuals for the comparison","Normal volunteers with no family history of PKD or other kidney diseases.",[19,22],{"name":20,"affiliation":5,"role":21},"Alan SL Yu, MD","PRINCIPAL_INVESTIGATOR",{"name":23,"affiliation":5,"role":21},"Darren P Wallace, PhD",[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Cathy Creed, RN","CONTACT","913-588-0053","ccreed@kumc.edu",[31,50,64],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"University of Chicago","RECRUITING","Chicago","Illinois","60637","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-87.65005,41.85003,{"lat":43,"lon":42},[46,49],{"name":47,"role":27,"phone":10,"phoneExt":10,"email":48},"Arlene Chapman, MD","Achapman1@medicine.bsd.uchicago.edu",{"name":47,"role":21,"phone":10,"phoneExt":10,"email":10},{"facility":5,"status":33,"city":51,"state":52,"zip":53,"country":37,"countryCode":38,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Kansas City","Kansas","66160",{"type":40,"coordinates":55},[56,57],-94.62746,39.11417,{"lat":57,"lon":56},[60,61],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":23,"role":27,"phone":62,"phoneExt":10,"email":63},"913-588-3889","dwallace@kumc.edu",{"facility":65,"status":33,"city":51,"state":66,"zip":67,"country":37,"countryCode":38,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Children's Mercy Hospital","Missouri","64108",{"type":40,"coordinates":69},[70,71],-94.57857,39.09973,{"lat":71,"lon":70},[74,78],{"name":75,"role":27,"phone":76,"phoneExt":10,"email":77},"Megan Mains, BSN","816-760-5918","mmmains@cmh.edu",{"name":79,"role":21,"phone":10,"phoneExt":10,"email":10},"Laurel Willig, MD, MS",{"type":81,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[83],{"name":84,"class":85},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100280926","early-pkd-observational-cohort-study-100280926",false,"NCT02936791","Early PKD Observational Cohort Study","EPOC","Inclusion Criteria:\n\n* Inclusion for early stage autosomal dominant polycystic kidney disease (ADPKD):\n\n  * Family history of PKD\n  * All races and ethnic groups\n  * Glomerular filtration rate (GFR) \\>80 ml\u002Fmin per 1.73 m2\n* Inclusion for Healthy Volunteers:\n\n  * Male or female with no family history of kidney disease\n  * All races and ethnic groups\n  * Normal GFR\n\nExclusion Criteria:\n\n* Non-insulin or insulin-dependent diabetes mellitus\n* Systemic illness (i.e.systemic lupus erythematosus, vasculitis)\n* Unable to provide written informed consent\n* Unavailable for magnetic resonance imaging (MRI) and blood\u002Furine collection",true,"ALL","4 Years","35 Years",{"count":98,"type":99},250,"ESTIMATED","10 Years","OBSERVATIONAL","This observational study will collect blood and urine and clinical information from individuals with early-stages of polycystic kidney disease (PKD), their unaffected siblings and normal volunteers to create a biobank, also called a biorepository. The long-term goal is to develop new knowledge on biological markers or biomarkers that indicate changes in the disease progression. An understanding of biomarkers for early renal cyst growth will benefit PKD patients as new therapies are being developed and tested.",[104],"Polycystic Kidney Disease",[106,107,108,109,5],"autosomal dominant polycystic kidney disease","ADPKD","PKD biomarkers","Kidney Institute","2026-04-23",{"date":112,"type":113},"2026-04-27","ACTUAL",{"date":115,"type":113},"2016-04",{"date":117,"type":99},"2031-06",{"name":5,"class":6},3]