[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100472073":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":28,"centralContacts":32,"locations":40,"responsibleParty":130,"collaborators":7,"id":132,"slug":133,"hasResults":134,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":134,"sex":140,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":7,"studyType":146,"phases":7,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":43,"whyStopped":7,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":167},{"fullName":5,"class":6},"University Children's Hospital Basel","OTHER",null,[9,13,16,19,22,25],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Lung function measurements","All lung function tests are non-invasive and last about 60 minutes per child:\n\n* Multiple Breath Washout: The nitrogen multiple-breath-washout test (N2MBW) measures ventilation inhomogeneity of the lung that occurs when smaller airways are damaged.\n* Spirometry\u002FBodyplethysmography\u002FDLCO: Spirometry measures dynamic air flows to quantify airway obstruction of large airways and pulmonary restriction. Plethysmography assesses static lung volumes. Diffusing capacity of the lung for carbon monoxide (DLCO) evaluates diffusion deficits.",{"type":10,"name":14,"description":15,"armGroupLabels":7,"otherNames":7},"Breath Analysis","Patients will exhale into a secondary electrospray-ionization-mass spectrometry (SESI-MS) breath analysis platform. SESI-MS allows real-time breath-printing by detection of both volatile and non-volatile trace components.",{"type":10,"name":17,"description":18,"armGroupLabels":7,"otherNames":7},"Magnetic resonance imaging (MRI)","Functional MRI scan assessing regional fractional lung ventilation and relative perfusion, followed by a morphological MRI scan. This technique allows simultaneous assessment of all affected lung components, the airways, alveoli and pulmonary vasculature.",{"type":6,"name":20,"description":21,"armGroupLabels":7,"otherNames":7},"Standardized interview to assess respiratory symptoms","Short questions on current airway symptoms, recent colds, exercise-related respiratory symptoms, and passive smoking exposure will be assessed. The interview takes about 10 minutes.",{"type":6,"name":23,"description":24,"armGroupLabels":7,"otherNames":7},"Data collection for assessment of clinical parameters and cumulative doses to chemotherapy, radiation, surgery and HSCT","Assessment of clinical parameters and cumulative doses to chemotherapy, radiation, surgery and hematopoietic stem cell transplantation (HSCT). Data on cumulative doses of pulmotoxic chemotherapy (carmustine, lomustine, busulfan, bleomycin, methotrexate and cyclophosphamide, fludarabine, ifosfamide, melphalan and thiotepa) and radiation therapy at the region of the chest from patient's hospital charts will be collected. Information on chest wall and lung surgery will be retrieved from the surgical reports. Information about conditioning regimens including cumulative chemotherapy doses and total body irradiation of patients undergoing HSCT will be collected. Further information on the health state of the patient and interventions (e.g. development of pneumonia, antibiotic treatment) will be collected from the hospital charts.",{"type":6,"name":26,"description":27,"armGroupLabels":7,"otherNames":7},"Collection of genetic samples","Germline DNA is collected (e.g. through saliva or buccal cell sampling) for later analysis on genetic risk factors for pulmonary complications.",[29],{"name":30,"affiliation":5,"role":31},"Jakob Usemann, PD Dr. med.","PRINCIPAL_INVESTIGATOR",[33,37],{"name":30,"role":34,"phone":35,"phoneExt":7,"email":36},"CONTACT","+41 61 704 12 12","jakob.usemann@ukbb.ch",{"name":38,"role":34,"phone":7,"phoneExt":7,"email":39},"Christine Schneider","Christine.Schneider@insel.ch",[41,62,84,98,115],{"facility":42,"status":43,"city":44,"state":7,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University Children's Hospital Basel (UKBB)","RECRUITING","Basel","4056","Switzerland","CH",{"type":49,"coordinates":50},"Point",[51,52],7.57327,47.55839,{"lat":52,"lon":51},[55,56,57,60],{"name":30,"role":34,"phone":35,"phoneExt":7,"email":36},{"name":30,"role":31,"phone":7,"phoneExt":7,"email":7},{"name":58,"role":59,"phone":7,"phoneExt":7,"email":7},"Nicolas Von der Weid, Prof. Dr. med.","SUB_INVESTIGATOR",{"name":61,"role":59,"phone":7,"phoneExt":7,"email":7},"Christina Schindera, Dr. med.",{"facility":63,"status":43,"city":64,"state":7,"zip":65,"country":46,"countryCode":47,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Universitätsklinik für Kinderheilkunde","Bern","3010",{"type":49,"coordinates":67},[68,69],7.44744,46.94809,{"lat":69,"lon":68},[72,76,80,81,83],{"name":73,"role":34,"phone":74,"phoneExt":7,"email":75},"Jochen Roessler, Prof. Dr. med.","+41 (0)31 632 94 95","jochen.roessler@insel.ch",{"name":77,"role":34,"phone":78,"phoneExt":7,"email":79},"Christine Schneider, Dr. med.","+41 (0)31 632 21 11","christine.schneider@insel.ch",{"name":73,"role":31,"phone":7,"phoneExt":7,"email":7},{"name":82,"role":59,"phone":7,"phoneExt":7,"email":7},"Philipp Latzin, Prof. Dr. med.",{"name":77,"role":59,"phone":7,"phoneExt":7,"email":7},{"facility":85,"status":43,"city":86,"state":7,"zip":87,"country":46,"countryCode":47,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Geneva University Hospital","Geneva","1211",{"type":49,"coordinates":89},[90,91],6.14569,46.20222,{"lat":91,"lon":90},[94,97],{"name":95,"role":34,"phone":7,"phoneExt":7,"email":96},"Marc Ansari, Prof. Dr. med.","marc.ansari@hcuge.ch",{"name":95,"role":31,"phone":7,"phoneExt":7,"email":7},{"facility":99,"status":43,"city":100,"state":7,"zip":101,"country":46,"countryCode":47,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Centre hospitalier universitaire vaudois Lausanne","Lausanne","1011",{"type":49,"coordinates":103},[104,105],6.63282,46.516,{"lat":105,"lon":104},[108,110,111,113],{"name":109,"role":34,"phone":7,"phoneExt":7,"email":7},"Manuel Diezi, Dr. med.",{"name":109,"role":31,"phone":7,"phoneExt":7,"email":7},{"name":112,"role":59,"phone":7,"phoneExt":7,"email":7},"Laura Crosazzo, Dr. med.",{"name":114,"role":59,"phone":7,"phoneExt":7,"email":7},"Sylvain Blanchon, Dr. med.",{"facility":116,"status":43,"city":117,"state":7,"zip":118,"country":46,"countryCode":47,"cosmosGeoPoint":119,"geoPoint":123,"contacts":124},"Universitäts-Kinderspital Zürich","Zurich","8032",{"type":49,"coordinates":120},[121,122],8.55,47.36667,{"lat":122,"lon":121},[125,127,128],{"name":126,"role":34,"phone":7,"phoneExt":7,"email":7},"Jean- Pierre Bourquin, Prof. Dr. med.",{"name":126,"role":31,"phone":7,"phoneExt":7,"email":7},{"name":129,"role":59,"phone":7,"phoneExt":7,"email":7},"Alexander Moeller, Prof. Dr. med.",{"type":131,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100472073","early-pulmonary-dysfunction-in-childhood-cancer-patients-100472073",false,"NCT05427136","Early Pulmonary Dysfunction in Childhood Cancer Patients","Prospective Multicentre Cohort Study of Early Pulmonary Dysfunction in Childhood Cancer Patients (SWISS-Pearl Study)","SWISS-Pearl","Inclusion Criteria:\n\n* at least one of the following cancer treatments:\n\n  * chest radiation\n  * treatment with any kind of chemotherapy\n  * hematopoietic stem cell transplantation (HSCT)\n  * thoracic surgery\n* consent for Childhood Cancer Registry (ChCR) registration\n\nExclusion Criteria:\n\n* no signed informed consent\n* Operation outside the chest area as only cancer treatment\n* Relapsed cancer (patients who develop relapse during the study will not be excluded)\n* In addition for MRI and lung function tests:\n\n  * Subjects who are respiratory insufficient and cannot perform a lung function test (less than 92% O2 saturation; under O2 therapy)\n  * Pregnant\n  * MRI measurement not possible without sedation\n  * Metal (e.g. pacemaker) in the body","ALL","4 Years","22 Years",{"count":144,"type":145},140,"ESTIMATED","OBSERVATIONAL","This longitudinal, prospective, multicentre study is to monitor lung function prospectively in childhood cancer patients after diagnosis. The impact of cancer treatment on pulmonary dysfunction non-invasively using lung function, lung imaging and breath analysis as well as clinical symptoms using a questionnaire will be assessed at different time points.",[149],"Pulmonary Dysfunction",[151,152,153,154,155,156,157],"Childhood cancer","Lung function","Lung imaging","Breath analysis","Exome-wide association studies (EWAS)","Genome-wide association studies (GWAS)","Pulmotoxic treatment","2026-05-04",{"date":160,"type":161},"2026-05-08","ACTUAL",{"date":163,"type":161},"2021-06-01",{"date":165,"type":145},"2051-06",{"name":5,"class":6},5]