[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590443":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":188,"collaborators":10,"id":190,"slug":191,"hasResults":192,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":10,"eligibilityCriteria":196,"healthyVolunteers":192,"sex":197,"minAge":198,"maxAge":10,"enrollmentInfo":199,"targetDuration":10,"studyType":202,"phases":10,"briefSummary":203,"conditions":204,"keywords":207,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":219},{"fullName":5,"class":6},"Alexion Pharmaceuticals, Inc.","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Ravulizumab",null,"Participants will receive Ravulizumab until Week 50 ± 14 days after baseline or until discontinuation.",[13],"Drug: Ravulizumab",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":10},"DRUG","Participants will receive Ravulizumab.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Alexion Pharmaceuticals, Inc. (Sponsor)","CONTACT","1-855-752-2356","clinicaltrials@alexion.com",[26,38,46,50,57,64,71,78,85,92,96,103,110,117,124,131,138,145,152,159,166,174,181],{"facility":27,"status":28,"city":29,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":10},"Clinical Trial Site","RECRUITING","Bergamo","Italy","IT",{"type":33,"coordinates":34},"Point",[35,36],9.66721,45.69601,{"lat":36,"lon":35},{"facility":27,"status":39,"city":40,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":41,"geoPoint":45,"contacts":10},"NOT_YET_RECRUITING","Bologna",{"type":33,"coordinates":42},[43,44],11.33875,44.49381,{"lat":44,"lon":43},{"facility":27,"status":28,"city":40,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":47,"geoPoint":49,"contacts":10},{"type":33,"coordinates":48},[43,44],{"lat":44,"lon":43},{"facility":27,"status":28,"city":51,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":52,"geoPoint":56,"contacts":10},"Brescia",{"type":33,"coordinates":53},[54,55],10.21472,45.53558,{"lat":55,"lon":54},{"facility":27,"status":28,"city":58,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":59,"geoPoint":63,"contacts":10},"Florence",{"type":33,"coordinates":60},[61,62],11.24626,43.77925,{"lat":62,"lon":61},{"facility":27,"status":39,"city":65,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":66,"geoPoint":70,"contacts":10},"Imperia",{"type":33,"coordinates":67},[68,69],8.03933,43.88917,{"lat":69,"lon":68},{"facility":27,"status":28,"city":72,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":73,"geoPoint":77,"contacts":10},"Lecco",{"type":33,"coordinates":74},[75,76],9.39704,45.85589,{"lat":76,"lon":75},{"facility":27,"status":39,"city":79,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":80,"geoPoint":84,"contacts":10},"Messina",{"type":33,"coordinates":81},[82,83],15.55256,38.19394,{"lat":83,"lon":82},{"facility":27,"status":28,"city":86,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":87,"geoPoint":91,"contacts":10},"Milan",{"type":33,"coordinates":88},[89,90],12.59836,42.78235,{"lat":90,"lon":89},{"facility":27,"status":39,"city":86,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":93,"geoPoint":95,"contacts":10},{"type":33,"coordinates":94},[89,90],{"lat":90,"lon":89},{"facility":27,"status":39,"city":97,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":98,"geoPoint":102,"contacts":10},"Naples",{"type":33,"coordinates":99},[100,101],14.26811,40.85216,{"lat":101,"lon":100},{"facility":27,"status":39,"city":104,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":105,"geoPoint":109,"contacts":10},"Novara",{"type":33,"coordinates":106},[107,108],8.62118,45.44694,{"lat":108,"lon":107},{"facility":27,"status":39,"city":111,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":112,"geoPoint":116,"contacts":10},"Orbassano",{"type":33,"coordinates":113},[114,115],7.53813,45.00547,{"lat":115,"lon":114},{"facility":27,"status":39,"city":118,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":119,"geoPoint":123,"contacts":10},"Padova",{"type":33,"coordinates":120},[121,122],11.14261,44.38225,{"lat":122,"lon":121},{"facility":27,"status":39,"city":125,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":126,"geoPoint":130,"contacts":10},"Palermo",{"type":33,"coordinates":127},[128,129],13.3636,38.1166,{"lat":129,"lon":128},{"facility":27,"status":28,"city":132,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":133,"geoPoint":137,"contacts":10},"Parma",{"type":33,"coordinates":134},[135,136],10.32618,44.79935,{"lat":136,"lon":135},{"facility":27,"status":39,"city":139,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":140,"geoPoint":144,"contacts":10},"Pavia",{"type":33,"coordinates":141},[142,143],9.15917,45.19205,{"lat":143,"lon":142},{"facility":27,"status":39,"city":146,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":147,"geoPoint":151,"contacts":10},"Pisa",{"type":33,"coordinates":148},[149,150],10.4036,43.70853,{"lat":150,"lon":149},{"facility":27,"status":39,"city":153,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":154,"geoPoint":158,"contacts":10},"Roma",{"type":33,"coordinates":155},[156,157],11.10642,44.99364,{"lat":157,"lon":156},{"facility":27,"status":39,"city":160,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":161,"geoPoint":165,"contacts":10},"Salerno",{"type":33,"coordinates":162},[163,164],14.79328,40.67545,{"lat":164,"lon":163},{"facility":27,"status":28,"city":167,"state":10,"zip":168,"country":30,"countryCode":31,"cosmosGeoPoint":169,"geoPoint":173,"contacts":10},"San Giovanni Rotondo","71013",{"type":33,"coordinates":170},[171,172],15.7277,41.70643,{"lat":172,"lon":171},{"facility":27,"status":28,"city":175,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":176,"geoPoint":180,"contacts":10},"Sassari",{"type":33,"coordinates":177},[178,179],8.55552,40.72586,{"lat":179,"lon":178},{"facility":27,"status":39,"city":182,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":183,"geoPoint":187,"contacts":10},"Torino",{"type":33,"coordinates":184},[185,186],11.99138,44.88856,{"lat":186,"lon":185},{"type":189,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100590443","early-ravulizumab-treatment-of-anti--achr-antibody-positive-generalized-myasthenia-gravis-100590443",false,"NCT06967480","Early Ravulizumab Treatment Of Anti- AChR Antibody-Positive Generalized Myasthenia Gravis","MG-EVOLUTION. Early Ravulizumab Treatment Of Anti- AChR Antibody-Positive Generalized Myasthenia Gravis: A Real-World Study With Biomarker Analysis","Inclusion Criteria:\n\n* Diagnosis of MG confirmed by:\n\n  * History of a positive serologic test for anti-AChR antibodies, and\n  * One of the following:\n\n    * History of abnormal neuromuscular transmission test demonstrated by singlefibre electromyography or repetitive nerve stimulation\n    * History of positive anticholinesterase test (e.g., edrophonium chloride test); or\n    * Patient demonstrated improvement in MG signs on oral cholinesterase inhibitors, as assessed by the treating physician\n* Disease duration from MG onset ≤ 3 years before T-4 (Enrolment);\n* MGFA class IIb to IV;\n* Patient eligible for Ravulizumab treatment based on AIFA reimbursement criteria\n* Vaccination cycle for Neisseria meningitidis completed at least two weeks before Ravulizumab initiation or antibiotics chemoprophylaxis according to the SmPC.\n\nExclusion Criteria:\n\n* Patient unable to understand and sign the informed consent\n* Hypersensitivity to the active substance or to any of the excipients of the study product\n* Patient for whom the study product is contraindicated according to SmPC\n* Previous treatment with C5 inhibitors\n* Last rituximab infusion performed \\\u003C 6 months before T-4 (Enrolment)\n* Last infusion with FcRn blockers performed \\\u003C 3 months before T-4 (Enrollment)\n* Pregnant or lactating or planning a pregnancy during the study\n* Patient who plan to relocate during the study\n* Patient who are unsure of following the visit schedule\n* Patient unable to complete questionnaires\n* Previous or current participation to other interventional studies","ALL","18 Years",{"count":200,"type":201},40,"ESTIMATED","OBSERVATIONAL","The primary objective of the study is to evaluate the effectiveness of Ravulizumab in improving MG-ADL in an early-stage AChR+ gMG population.",[205,206],"Generalized Myasthenia Gravis","Anti-AChR Antibody Positive",[208,205,209,9],"Anti-AChR Antibody-Positive","gMG","2026-02-04",{"date":212,"type":213},"2026-02-05","ACTUAL",{"date":215,"type":213},"2025-07-31",{"date":217,"type":201},"2027-06-30",{"name":5,"class":6},23]