[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100510277":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":10,"centralContacts":34,"locations":43,"responsibleParty":59,"collaborators":63,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":10,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"UMC Utrecht","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Cohort 1",null,"60 adolescent girls (8-10 years old) at increased risk for idiopathic scoliosis development (an older sibling or parent diagnosed with idiopathic scoliosis)",[13,14,15],"Diagnostic Test: MRI","Diagnostic Test: Scolioscan","Diagnostic Test: Skeletal maturity assessment",{"label":17,"type":10,"description":18,"interventionNames":19},"Cohort 2","60 adolescent girls or boys with the 22q11.2DS with increased risk for idiopathic-like scoliosis development.",[13,14,15],[21,26,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DIAGNOSTIC_TEST","MRI","Longitudinal MRI examination of the thoracic and lumbar spine (T2, T2w, sCT)",[9,17],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Scolioscan","3D ultrasound of the spine",[9,17],{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Skeletal maturity assessment","At one timepoint, a Hand radiograph is taken for digital skeletal maturity assessment",[9,17],[35,40],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Tom Schlosser","CONTACT","+31 88 75 53602","t.p.c.schlosser@umcutrecht.nl",{"name":41,"role":37,"phone":10,"phoneExt":10,"email":42},"Hilde Stempels","h.w.stempels@umcutrecht.nl",[44],{"facility":5,"status":45,"city":46,"state":10,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Utrecht","3584 CX","Netherlands","NL",{"type":51,"coordinates":52},"Point",[53,54],5.12222,52.09083,{"lat":54,"lon":53},[57],{"name":58,"role":37,"phone":10,"phoneExt":10,"email":39},"Tom Schlösser, MD, PhD",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","dr. Tom P.C. Schlösser","Principal Investigator",[64],{"name":65,"class":6},"Eindhoven University of Technology","100510277","early-scoliotic-changes-in-children-at-increased-risk-for-scoliosis-development-100510277",false,"NCT05924347","Early Scoliotic Changes in Children at Increased Risk for Scoliosis Development","Longitudinal MRI Study to Catch EARLY Scoliotic Changes of the Bone and Intervertebral Disc in Younger Sisters and Daughters of Adolescent Idiopathic Scoliosis Patients and the 22q11.2DS Population.","EARLYBIRD","Inclusion Criteria:\n\nCohort 1:\n\n* Female,\n* 8, 9 or 10 years old\n* An older sibling, twin or parent diagnosed with AIS\n\nCohort 2:\n\n* Diagnosed with 22q11.2DS\n* Girls: 8, 9 or 10 years old.\n* Boys: 9, 10 or 11 years old.\n\nAll\n\n* No clinical signs of scoliosis at inclusion (physical examination by forward bending test and Bunnell Scoliometer assessment with a cut-off value of 7°.\n* Written informed consent of parents\u002Flegal representatives.\n\nExclusion Criteria:\n\n* Contraindications for MR imaging\n* Early-onset scoliosis or other spinal deformities\n* Other syndromes or neuromuscular disease associated with scoliosis\n* Clinical signs of \\>1cm leg length discrepancy\n* Other diseases or injuries, that are related to abnormal spinal growth, posture, activity levels, or scoliosis development.","ALL","8 Years","11 Years",{"count":78,"type":79},120,"ESTIMATED","OBSERVATIONAL","Rationale: Despite several decades of research, the exact etiology of adolescent idiopathic scoliosis (AIS) remains unclear. In AIS, spine curvature begins with and progresses during the adolescent growth spurt. Previous studies are only performed on populations with already established scoliosis and normal spinal growth (of bone and IVD tissue) during adolescence has also not been defined. Growth pattern differences may exist between scoliotic and nonscoliotic subjects. Previous studies support the hypothesis that AIS is a spinal deformity that starts with decompensation in the IVD and is linked to sagittal spinal alignment. However, to understand its cause and pathogenic mechanism, the changes to the adolescent spine must be assessed longitudinally during the growth period coinciding with the period prior to and during the onset of AIS. Ideally this should include a cohort who do and do not develop AIS and their assessment must be minimally harmful, without radiation exposure. Certain populations are at increased risk for scoliosis development (i.e. girls with family members with scoliosis and 22q11.2DS patients). New imaging modalities (boneMRI, 3D spinal ultrasound) allow for non-radiographic monitoring of spinal growth.",[83,84],"Adolescent Idiopathic Scoliosis","22q11.2 Deletion Syndrome","2023-06-20",{"date":87,"type":88},"2023-06-29","ACTUAL",{"date":90,"type":88},"2023-06-16",{"date":92,"type":79},"2032-05-01",{"name":5,"class":6},1]