[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599330":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":104,"collaborators":28,"id":106,"slug":107,"hasResults":108,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":114,"sex":115,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":28,"studyType":121,"phases":122,"briefSummary":124,"conditions":125,"keywords":129,"overallStatus":42,"whyStopped":28,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":143},{"fullName":5,"class":6},"Cilcare SAS","INDUSTRY",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","OTHER","Control population",[13],"Other: Thorough Hearing assessment",{"label":15,"type":16,"description":17,"interventionNames":18},"Amnestic MCI Group","EXPERIMENTAL","Patients with amnestic mild cognitive impairment",[13],{"label":20,"type":16,"description":21,"interventionNames":22},"Parkinson Group","Patient with parkinson's disease",[13],[24],{"type":10,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Thorough Hearing assessment","Otoscopy Tympanometry Tonal audiometry (air and bone conduction) Vocal audiometry (in silence and in noise) Distorsion Products of OtoAcoustic Emissions (DPOAE) Middle Ear Muscle Reflex (MEMR) Auditory Brainstem Response (ABR) Electrocochleography (EcochG)",[15,9,20],null,[30],{"name":31,"affiliation":5,"role":32},"Mathieu SCHUE, PhD","STUDY_DIRECTOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":28,"email":38},"Laura BREDA, Master's degree","CONTACT","+33769042226","laura.breda@cilcare.com",[40,57,74,88],{"facility":41,"status":42,"city":43,"state":28,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"CHU Gui de Chauliac","RECRUITING","Montpellier","34080","France","FR",{"type":48,"coordinates":49},"Point",[50,51],3.87635,43.61093,{"lat":51,"lon":50},[54],{"name":55,"role":56,"phone":28,"phoneExt":28,"email":28},"Audrey GABELLE, MD","PRINCIPAL_INVESTIGATOR",{"facility":58,"status":42,"city":59,"state":28,"zip":60,"country":45,"countryCode":46,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"CHU Nice","Nice","06000",{"type":48,"coordinates":62},[63,64],7.26608,43.70313,{"lat":64,"lon":63},[67,69,72],{"name":68,"role":56,"phone":28,"phoneExt":28,"email":28},"Guillaume SACCO, MD",{"name":70,"role":71,"phone":28,"phoneExt":28,"email":28},"Aurélie MOUTON, MD","SUB_INVESTIGATOR",{"name":73,"role":71,"phone":28,"phoneExt":28,"email":28},"Caroline GIORDANA, MD",{"facility":75,"status":42,"city":76,"state":28,"zip":77,"country":45,"countryCode":46,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"CHU Carémeau","Nîmes","30900",{"type":48,"coordinates":79},[80,81],4.35788,43.83665,{"lat":81,"lon":80},[84,86],{"name":85,"role":56,"phone":28,"phoneExt":28,"email":28},"Cassiana TRANDAFIR, MD",{"name":87,"role":71,"phone":28,"phoneExt":28,"email":28},"Giovanni CASTELNOVO, MD",{"facility":89,"status":42,"city":90,"state":28,"zip":91,"country":45,"countryCode":46,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Hospices Civils de Lyon, Hôpital des Charpennes","Villeurbanne","69100",{"type":48,"coordinates":93},[94,95],4.8795,45.76601,{"lat":95,"lon":94},[98,100,102],{"name":99,"role":56,"phone":28,"phoneExt":28,"email":28},"Sophie DAUTRICOURT, MD",{"name":101,"role":71,"phone":28,"phoneExt":28,"email":28},"Antoine GARNIER CRUSSARD, MD",{"name":103,"role":71,"phone":28,"phoneExt":28,"email":28},"Fannie BRETELLE, MD",{"type":105,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100599330","early-stage-of-alzheimers-and-parkinsons-diseases-hearing-relevance-saphir-100599330",false,"NCT07083089","Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)","Phenotyping of Audition in Patients With Early Stage of Neurodegenerative Disorders (Alzheimer and Parkinson' Diseases)","SAPHIR","Inclusion Criteria: All subjects\n\n1. Man or woman aged between 50 and 85 years old at baseline.\n2. Fluent in French (native language)\n3. Be considered as reliable and capable of adhering to the protocol, according to the judgment of the investigator (understanding of the information included in the protocol, and requests to realize the investigations, good general health and able to move around).\n4. Affiliated to Public Health Insurance (Sécurité Sociale)\n5. Signed and dated informed consent form.\n\nFor amnestic MCI:\n\nDiagnosis of amnestic MCI, according to international diagnosis criteria (NIA-AA, 2011) with MoCA≥23 or MMSE\\>24.Patients must exhibit predominantly cognitive impairments in episodic memory, defined by a score on the RL\u002FRI 16-item test with a free recall score of less than 18\u002F48 and a total recall score of less than 40\u002F48.\n\nFor Parkinson Patients:\n\nEstablished clinical diagnosis of Parkinson's disease according to Postuma et al. 2015 with bradykinesia associated with resting tremor or rigidity, no exclusion criteria or red flag with MOCA ≥23.\n\nFor controls:\n\nNo diagnosis of neurological disease such as Parkinson's disease or MCI associated or not with Alzheimer's disease Displays normal cognitive status with a MoCA score ≥ 26.\n\nNon-inclusion criteria:\n\n1. Known hearing pathologies leading to conductive hearing loss (otosclerosis, a diagnosed pathology of the ear canal, tympanic membrane, ossicles or 3rd window), otitis, congenital deafness or sensorineural hearing loss associated to Menière's disease.\n2. Psychiatric diseases other than neurodegenerative etiology\n3. Neurological or neurovascular disorders (Stroke, epilepsy, dementia)\n4. Motor complications that could interfere with audiological assessment\n5. Known Diagnosis of type 2 diabetes\n6. Alcohol or drug addiction\n7. Cochlear implant\n8. Known ototoxic drug therapy:\n\n   1. Antibiotics: Aminosides IV, macrolides, tetracyclines in the last 15 days prior to inclusion\n   2. Antipaludic drugs: quinine, hydroxychloroquine, chloroquine in the last 15 days prior to inclusion\n   3. Platinum-based chemotherapy at any time prior to inclusion.\n   4. Loop diuretics: furosemide (max oral dose of ≤60mg\u002Fday) at inclusion and during the study.\n   5. Salicylate derivatives at high dose (Kardegic allowed at dose ≤320mg\u002Fday) at inclusion and during the study.\n9. History of otological surgical act.\n10. On-going pregnancy or breast-feeding.\n11. Adults protected by law: in vulnerable social situations or unable to express consent.\n12. Under another protocol that may interfere with the analysis of the results.\n\nExclusion Criteria:\n\nPatients will be excluded from the study if one or more of the following criteria are applicable during visit 2:\n\n1. Abnormal otoscopy as defined by less than 90% of the tympanic membrane visible (cerumen ear plug, ear drum perforation, …)\n2. Conductive hearing loss defined by an air-bone threshold gap of 10 dB or greater based on the average of frequencies 0.5, 1, 2, and 4 kHz, and abnormal hearing thresholds (greater than 20 dB HL) for these frequencies.\n3. Abnormal tympanogram (other type than A)\n4. Asymmetric hearing loss: more than 15 dB difference in the pure-tone average (PTA) air conduction (for MCI patients and control group only)\n5. Single-sided deafness (SSD)\n6. Cophosis (PTAv \\> 120 dB)",true,"ALL","50 Years","85 Years",{"count":119,"type":120},309,"ESTIMATED","INTERVENTIONAL",[123],"NA","The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population. Specific focus is made on patients with speech-in-noise intelligibiltiy deficit despite normal tonal audiograms referred to as hidden hearing loss, with potential identification of associated biomarkers.",[126,127,128],"Mild Cognitive Impairment (MCI) Amnestic","Parkinson Disease (PD)","Healthy Participants",[130,131,132,133],"hearing phenotype","audiometry","speech-in-noise intelligibility","electrophysiology","2025-12-08",{"date":136,"type":137},"2025-12-09","ACTUAL",{"date":139,"type":137},"2025-03-24",{"date":141,"type":120},"2026-12",{"name":5,"class":6},4]